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Peer-reviewedCC BY-NCJournal of Parkinson's disease

Genetic and personality interactions shape impulse control disorders in Parkinson's disease.

  • Mathilde Boussac1
  • Paulo André Dias Bastos2
  • Thomas Wirth3,4
  • Aymeric Lanore5
  • Estelle Harroch2
  • Louise-Laure Mariani5
  • Mathieu Anheim3,4
  • Jean-Christophe Corvol5
  • Christine Brefel-Courbon1,2
  • BADGE-PD study group
5 affiliations
  1. 1Toulouse NeuroImaging Center (ToNIC), Inserm UMR1214, University of Toulouse III, UPS, Toulouse, France.
  2. 2Department of Clinical Pharmacology and Neurosciences, Parkinson Expert Center, Clinical Investigation Center, University Hospital of Toulouse, NeuroToul COEN (Center of Excellence in Neurodegeneration), Toulouse, France.
  3. 3Service de Neurologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
  4. 4Département de Médecine Translationnelle et Neurogénétique, Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM-U964/CNRS-UMR7104/Université de Strasbourg, Illkirch-Graffenstaden, France.
  5. 5Assistance Publique Hôpitaux de Paris, Department of Neurology, CIC Neurosciences, NS-Park/F-CRIN, Hôpital Pitié-Salpêtrière, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Sorbonne University, Paris, France.
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Abstract

BackgroundIn Parkinson's disease (PD), predictive factors of Impulse Control Disorders (ICDs) remain insufficiently understood. Personality and polygenic risk scores (PRS) have both been independently associated with ICDs.ObjectivesOur objective was to study the interaction effects between personality dimensions and PRS on the odds of developing ICDs.MethodsThis case-control study included PD patients with and without ICDs (n = 250 patients). Personality was assessed using the Temperament and Character Inventory-Revised, and PRS were computed from genotyping data across 18 traits linked to psychiatric/behavioral phenotypes. Logistic regression models were used to evaluate main and interaction effects between personality dimensions and PRS on ICD odds.ResultsHigher scores in Self-Directedness, attention deficit hyperactivity disorder (ADHD)-PRS, and major depressive disorder (MDD)-PRS were associated with increased odds of ICD (odds ratios (ORs) between 1.31 and 1.54). Several personality*PRS interactions also significantly modulated the odds of developing ICDs. Notably, Novelty Seeking*MDD PRS and Harm Avoidance*MDD PRS interactions amplified the odds of ICD (ORs = 1.34 and 1.30, respectively), while the Harm Avoidance*ADHD PRS interaction attenuated it (OR = 0.74). Self-Directedness interactions showed both odds amplification (with PD-PRS [OR = 1.34] and MDD-PRS [OR = 1.43]) and slight attenuation (with ADHD-PRS [OR = 0.73]).ConclusionsThis study provides novel evidence that the odds of having ICD are modulated by cumulative and interactive effects of personality and genes in PD. Self-Directedness, ADHD and MDD PRS were individually associated with ICDs, and their combinations yielded complex, non-additive effects-either amplifying or attenuating odds. These findings highlight the importance of integrating both psychological and genetic profiles in personalized risk assessment for ICDs.

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Cite

BibTeXRIS
BibTeX
@article{boussac2026genetic,
  title = {{Genetic and personality interactions shape impulse control disorders in Parkinson's disease.}},
  author = {Mathilde Boussac and Paulo André Dias Bastos and Thomas Wirth and Aymeric Lanore and Estelle Harroch and Louise-Laure Mariani and Mathieu Anheim and Jean-Christophe Corvol and Christine Brefel-Courbon and BADGE-PD study group},
  journal = {Journal of Parkinson's disease},
  year = {2026},
  month = oct,
  doi = {10.1177/1877718x261499529},
  url = {https://europepmc.org/article/MED/42911097},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Genetic and personality interactions shape impulse control disorders in Parkinson's disease.
AU  - Mathilde Boussac
AU  - Paulo André Dias Bastos
AU  - Thomas Wirth
AU  - Aymeric Lanore
AU  - Estelle Harroch
AU  - Louise-Laure Mariani
AU  - Mathieu Anheim
AU  - Jean-Christophe Corvol
AU  - Christine Brefel-Courbon
AU  - BADGE-PD study group
PY  - 2026
DA  - 2026/10/22
JO  - Journal of Parkinson's disease
DO  - 10.1177/1877718x261499529
UR  - https://europepmc.org/article/MED/42911097
AB  - BackgroundIn Parkinson's disease (PD), predictive factors of Impulse Control Disorders (ICDs) remain insufficiently understood. Personality and polygenic risk scores (PRS) have both been independently associated with ICDs.ObjectivesOur objective was to study the interaction effects between personality dimensions and PRS on the odds of developing ICDs.MethodsThis case-control study included PD patients with and without ICDs (n = 250 patients). Personality was assessed using the Temperament and Character Inventory-Revised, and PRS were computed from genotyping data across 18 traits linked to psychiatric/behavioral phenotypes. Logistic regression models were used to evaluate main and interaction effects between personality dimensions and PRS on ICD odds.ResultsHigher scores in Self-Directedness, attention deficit hyperactivity disorder (ADHD)-PRS, and major depressive disorder (MDD)-PRS were associated with increased odds of ICD (odds ratios (ORs) between 1.31 and 1.54). Several personality*PRS interactions also significantly modulated the odds of developing ICDs. Notably, Novelty Seeking*MDD PRS and Harm Avoidance*MDD PRS interactions amplified the odds of ICD (ORs = 1.34 and 1.30, respectively), while the Harm Avoidance*ADHD PRS interaction attenuated it (OR = 0.74). Self-Directedness interactions showed both odds amplification (with PD-PRS [OR = 1.34] and MDD-PRS [OR = 1.43]) and slight attenuation (with ADHD-PRS [OR = 0.73]).ConclusionsThis study provides novel evidence that the odds of having ICD are modulated by cumulative and interactive effects of personality and genes in PD. Self-Directedness, ADHD and MDD PRS were individually associated with ICDs, and their combinations yielded complex, non-additive effects-either amplifying or attenuating odds. These findings highlight the importance of integrating both psychological and genetic profiles in personalized risk assessment for ICDs.
SN  - 1877-7171
SN  - 1877-718X
ER  -