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Peer-reviewedCC BY 4.0Veterinary Research

Mechanisms of antibody-dependent enhancement and its research progress in animal coronaviruses

  • Zhiding Zhou
  • Yueyue Liu
  • Meilin Yang
  • Cunyi Qiu
  • Jing Xia
  • Yong Huang
  • Yefei Zhou
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Abstract

Animal coronaviruses are associated with serious diseases in livestock and poultry, resulting in substantial economic losses worldwide. Antibody-dependent enhancement (ADE) is a phenomenon whereby pre‑existing pathogen specific antibodies may paradoxically exacerbate viral infections. In this review, we synthesize current classifications of ADE mechanisms, presenting a unified framework comprising two major categories subdivided into five distinct mechanistic subsets. Given the limited research on ADE in animal coronaviruses, we use SARS‑CoV‑2 as a case study to explore five potential ADE mechanisms associated with coronavirus infection. This review aims to provide a valuable reference for elucidating ADE mechanisms in animal coronaviruses.

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Cite

BibTeXRIS
BibTeX
@article{zhou2026mechanisms,
  title = {{Mechanisms of antibody-dependent enhancement and its research progress in animal coronaviruses}},
  author = {Zhiding Zhou and Yueyue Liu and Meilin Yang and Cunyi Qiu and Jing Xia and Yong Huang and Yefei Zhou},
  journal = {Veterinary Research},
  year = {2026},
  month = sep,
  doi = {10.1186/s13567-026-01837-4},
  url = {https://hal.science/hal-05756337v1},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Mechanisms of antibody-dependent enhancement and its research progress in animal coronaviruses
AU  - Zhiding Zhou
AU  - Yueyue Liu
AU  - Meilin Yang
AU  - Cunyi Qiu
AU  - Jing Xia
AU  - Yong Huang
AU  - Yefei Zhou
PY  - 2026
DA  - 2026/09/21
JO  - Veterinary Research
DO  - 10.1186/s13567-026-01837-4
UR  - https://hal.science/hal-05756337v1
AB  - Animal coronaviruses are associated with serious diseases in livestock and poultry, resulting in substantial economic losses worldwide. Antibody-dependent enhancement (ADE) is a phenomenon whereby pre‑existing pathogen specific antibodies may paradoxically exacerbate viral infections. In this review, we synthesize current classifications of ADE mechanisms, presenting a unified framework comprising two major categories subdivided into five distinct mechanistic subsets. Given the limited research on ADE in animal coronaviruses, we use SARS‑CoV‑2 as a case study to explore five potential ADE mechanisms associated with coronavirus infection. This review aims to provide a valuable reference for elucidating ADE mechanisms in animal coronaviruses.
SN  - 0928-4249
SN  - 1297-9716
ER  -