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Peer-reviewedCC BY 4.0Chemmedchem

What Method and Library Size Is Best for Fragment Screening?

  • Stephen W. Fesik1
  1. 1Departments of Biochemistry, Pharmacology and Chemistry Vanderbilt University Nashville Tennessee USA
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Abstract

Fragment screening is widely used to provide useful starting points for drug discovery. There are many methods that are used today for conducting fragment‐based screens. and fragment libraries vary widely in size. In this perspective, I discuss the method that I use for fragment screening and the size of my fragment library, the reasons for these choices, and provide an example that illustrates the advantages.

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Cite

BibTeXRIS
BibTeX
@article{fesik2026what,
  title = {{What Method and Library Size Is Best for Fragment Screening?}},
  author = {Stephen W. Fesik},
  journal = {Chemmedchem},
  year = {2026},
  month = nov,
  doi = {10.1002/cmdc.70503},
  url = {https://doi.org/10.1002/cmdc.70503},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - What Method and Library Size Is Best for Fragment Screening?
AU  - Stephen W. Fesik
PY  - 2026
DA  - 2026/11/03
JO  - Chemmedchem
DO  - 10.1002/cmdc.70503
UR  - https://doi.org/10.1002/cmdc.70503
AB  - Fragment screening is widely used to provide useful starting points for drug discovery. There are many methods that are used today for conducting fragment‐based screens. and fragment libraries vary widely in size. In this perspective, I discuss the method that I use for fragment screening and the size of my fragment library, the reasons for these choices, and provide an example that illustrates the advantages.
SN  - 1860-7179
SN  - 1860-7187
ER  -