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Peer-reviewedCC BY 4.0International Journal of Molecular Sciences

Circulating α-Klotho Is Elevated in Breast Cancer and Positively Correlates with IGF-1

  • Shira Ben Neriah1
  • Marana Abboud1,2
  • Alla Berlin1
  • Rina Hemi3
  • Rona Aks1
  • Shiran Shapira1,2
  • Ido Wolf1,2
  • Tami Rubinek1,2
  1. 1Department of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel
  2. 2Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel
  3. 3Endocrinology Institute, Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel
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Abstract

Breast cancer (BC) is the most commonly diagnosed cancer among women worldwide. Klotho is an anti-aging protein implicated in tumor suppression; however, the relationship between circulating Klotho levels and BC remains unclear. We measured serum Klotho by enzyme-linked immunosorbent assay (ELISA) in 372 participants: 166 patients with BC, 24 patients with ductal carcinoma in situ (DCIS), and 182 controls, and examined its relation to clinicopathological characteristics, including estrogen receptor (ER), progesterone receptor (PR), HER2 and lymph node status, body mass index (BMI), and insulin-like growth factor 1 (IGF-1). Serum Klotho levels were significantly higher in invasive BC and DCIS patients compared with controls (p = 0.003 and p = 0.001, respectively), whereas no significant difference was detected between invasive BC and DCIS. After adjustment for age, Klotho levels remained significantly higher in BC and DCIS patients than in controls. Klotho levels correlated positively with IGF-1 (p = 0.0043), but not with BMI, ER, PR, HER2, or lymph node status. These preliminary findings demonstrate an association between elevated circulating Klotho and BC, as well as a positive relationship between Klotho and IGF-1. Further studies using age-matched cohorts and diagnostic-performance analyses are required to determine whether circulating Klotho has clinical utility as a BC biomarker.

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Cite

BibTeXRIS
BibTeX
@article{neriah2026circulating,
  title = {{Circulating α-Klotho Is Elevated in Breast Cancer and Positively Correlates with IGF-1}},
  author = {Shira Ben Neriah and Marana Abboud and Alla Berlin and Rina Hemi and Rona Aks and Shiran Shapira and Ido Wolf and Tami Rubinek},
  journal = {International Journal of Molecular Sciences},
  year = {2026},
  month = oct,
  doi = {10.3390/ijms27209257},
  url = {https://www.mdpi.com/1422-0067/27/20/9257},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Circulating α-Klotho Is Elevated in Breast Cancer and Positively Correlates with IGF-1
AU  - Shira Ben Neriah
AU  - Marana Abboud
AU  - Alla Berlin
AU  - Rina Hemi
AU  - Rona Aks
AU  - Shiran Shapira
AU  - Ido Wolf
AU  - Tami Rubinek
PY  - 2026
DA  - 2026/10/01
JO  - International Journal of Molecular Sciences
DO  - 10.3390/ijms27209257
UR  - https://www.mdpi.com/1422-0067/27/20/9257
AB  - Breast cancer (BC) is the most commonly diagnosed cancer among women worldwide. Klotho is an anti-aging protein implicated in tumor suppression; however, the relationship between circulating Klotho levels and BC remains unclear. We measured serum Klotho by enzyme-linked immunosorbent assay (ELISA) in 372 participants: 166 patients with BC, 24 patients with ductal carcinoma in situ (DCIS), and 182 controls, and examined its relation to clinicopathological characteristics, including estrogen receptor (ER), progesterone receptor (PR), HER2 and lymph node status, body mass index (BMI), and insulin-like growth factor 1 (IGF-1). Serum Klotho levels were significantly higher in invasive BC and DCIS patients compared with controls (p = 0.003 and p = 0.001, respectively), whereas no significant difference was detected between invasive BC and DCIS. After adjustment for age, Klotho levels remained significantly higher in BC and DCIS patients than in controls. Klotho levels correlated positively with IGF-1 (p = 0.0043), but not with BMI, ER, PR, HER2, or lymph node status. These preliminary findings demonstrate an association between elevated circulating Klotho and BC, as well as a positive relationship between Klotho and IGF-1. Further studies using age-matched cohorts and diagnostic-performance analyses are required to determine whether circulating Klotho has clinical utility as a BC biomarker.
SN  - 1422-0067
ER  -