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Peer-reviewedCC BYMedicine

Research hotspots and evolution trends of human amniotic fluid stem cells: A cite space bibliometric analysis based on WoSCC and PubMed.

  • Huanying Lou1
  • Zheng Wang1
  • Shuai Zhang1
  • Feng Wang1
  • Qiang Feng2
  • Yi Li1
  1. 1Prenatal Diagnostic Laboratory, The Affiliated Taian City Central Hospital of Qingdao University, Taian, China.
  2. 2Department of Medical Laboratory Science, The Affiliated Taian City Central Hospital of Qingdao University, Taian, China.
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Abstract

Objective

To systematically review the research hotspots, knowledge structure, and evolution trends in the field of human amniotic fluid stem cells (hAFSCs).Methods

A bibliometric approach was employed using CiteSpace 6.2.R4 software, with the Web of Science Core Collection (WoSCC, 2006-2026, including 601 original research papers) and PubMed (1984-2024, including 960 publications) as data sources. Standardized, reproducible search strategies (including synonyms, abbreviations, MeSH terms, and Boolean operators) were developed for each database, and literature screening followed the PRISMA 2020 guidelines. Using the WoSCC dataset as the core, we generated comprehensive visualizations covering author collaboration networks, countries, institutions, keyword co-occurrence, clustering, timelines, time zones, and emerging terms; the PubMed data were used for comparison of long-term publication trends.Results

The global publication volume in the field of hAFSCs has shown an overall upward trend, which can be divided into 3 phases: exploratory inception (1984-2006), rapid growth (2007-2013), and stable deepening (2014 to present). The United States (177 articles) and Italy (132 articles) form the dual engines of international collaboration, while China ranks third in publication volume (75 articles) but exhibits relatively weak international collaboration (centrality 0.02). The evolution of research themes is clear: from 2006 to 2009, the focus was on cell isolation, characterization, and in vitro culture; from 2010 to 2015, the scope expanded to multipotent differentiation, animal models, and the treatment of fetal diseases; and since 2018, exosomes/extracellular vesicles have emerged as the most active frontier with the highest emergence intensity (7.37).Conclusion

Bibliometric analysis indicates that research on hAFSCs has evolved from basic biological characterization into a comprehensive field encompassing multipotent differentiation, tissue engineering, and exosome regulation. Exosomes/extracellular vesicles and targeted repair of organ damage are currently the primary areas of focus. This study is a descriptive analysis; all conclusions are based on publication trend statistics and do not involve validation of clinical translational efficacy.

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Cite

BibTeXRIS
BibTeX
@article{lou2026research,
  title = {{Research hotspots and evolution trends of human amniotic fluid stem cells: A cite space bibliometric analysis based on WoSCC and PubMed.}},
  author = {Huanying Lou and Zheng Wang and Shuai Zhang and Feng Wang and Qiang Feng and Yi Li},
  journal = {Medicine},
  year = {2026},
  month = oct,
  doi = {10.1097/md.0000000000051013},
  url = {https://europepmc.org/article/MED/42888595},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Research hotspots and evolution trends of human amniotic fluid stem cells: A cite space bibliometric analysis based on WoSCC and PubMed.
AU  - Huanying Lou
AU  - Zheng Wang
AU  - Shuai Zhang
AU  - Feng Wang
AU  - Qiang Feng
AU  - Yi Li
PY  - 2026
DA  - 2026/10/01
JO  - Medicine
DO  - 10.1097/md.0000000000051013
UR  - https://europepmc.org/article/MED/42888595
AB  - Objective  To systematically review the research hotspots, knowledge structure, and evolution trends in the field of human amniotic fluid stem cells (hAFSCs).Methods  A bibliometric approach was employed using CiteSpace 6.2.R4 software, with the Web of Science Core Collection (WoSCC, 2006-2026, including 601 original research papers) and PubMed (1984-2024, including 960 publications) as data sources. Standardized, reproducible search strategies (including synonyms, abbreviations, MeSH terms, and Boolean operators) were developed for each database, and literature screening followed the PRISMA 2020 guidelines. Using the WoSCC dataset as the core, we generated comprehensive visualizations covering author collaboration networks, countries, institutions, keyword co-occurrence, clustering, timelines, time zones, and emerging terms; the PubMed data were used for comparison of long-term publication trends.Results  The global publication volume in the field of hAFSCs has shown an overall upward trend, which can be divided into 3 phases: exploratory inception (1984-2006), rapid growth (2007-2013), and stable deepening (2014 to present). The United States (177 articles) and Italy (132 articles) form the dual engines of international collaboration, while China ranks third in publication volume (75 articles) but exhibits relatively weak international collaboration (centrality 0.02). The evolution of research themes is clear: from 2006 to 2009, the focus was on cell isolation, characterization, and in vitro culture; from 2010 to 2015, the scope expanded to multipotent differentiation, animal models, and the treatment of fetal diseases; and since 2018, exosomes/extracellular vesicles have emerged as the most active frontier with the highest emergence intensity (7.37).Conclusion  Bibliometric analysis indicates that research on hAFSCs has evolved from basic biological characterization into a comprehensive field encompassing multipotent differentiation, tissue engineering, and exosome regulation. Exosomes/extracellular vesicles and targeted repair of organ damage are currently the primary areas of focus. This study is a descriptive analysis; all conclusions are based on publication trend statistics and do not involve validation of clinical translational efficacy.
SN  - 0304-5412
SN  - 1536-5964
ER  -