Abdominal Pain in Inflammatory Bowel Diseases: A Clinical Challenge
Abstract
Up to 60% of inflammatory bowel disease (IBD) patients experience abdominal pain in their lifetime regardless of disease activity. Pain negatively affects different areas of daily life and particularly impacts the quality of life of IBD patients. This review provides a comprehensive overview of the multifactorial etiology implicated in the chronic abdominal pain of IBD patients including peripheral sensitization by inflammation, coexistent irritable bowel syndrome, visceral hypersensitivity, alteration of the brain–gut axis, and the multiple factors contributing to pain persistence. Despite the optimal management of intestinal inflammation, chronic abdominal pain can persist, and pharmacological and non-pharmacological approaches are necessary. Integrating psychological support in care models in IBD could decrease disease burden and health care costs. Consequently, a multidisciplinary approach similar to that used for other chronic pain conditions should be recommended.
Related
- Interpreting graph neural networks reveals microbial association patterns in inflammatory bowel diseases
- Chronic conditions associated with paediatric onset inflammatory bowel diseases: A population‐based study
- Acceptability of probiotics, fecal microbiota transplantation, and emerging microbiome-derived therapies in patients with inflammatory bowel diseases: A cross-sectional Survey Study
- Clinical characteristics and phenotypes of inflammatory bowel disease in Northern Central America: initial results from the Northern Central America Inflammatory Bowel Disease Registry.
- Very early onset inflammatory bowel disease in Jordan: a single-center case series of clinical, genetic, and therapeutic features.
BibTeX
@article{wils2026abdominal,
title = {{Abdominal Pain in Inflammatory Bowel Diseases: A Clinical Challenge}},
author = {Pauline Wils and Bénédicte Caron and Ferdinando d'Amico and Silvio Danese and Laurent Peyrin‐biroulet},
journal = {Journal of Clinical Medicine},
year = {2026},
month = sep,
doi = {10.3390/jcm11154269},
url = {https://hal.univ-lorraine.fr/hal-04167942v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Abdominal Pain in Inflammatory Bowel Diseases: A Clinical Challenge
AU - Pauline Wils
AU - Bénédicte Caron
AU - Ferdinando d'Amico
AU - Silvio Danese
AU - Laurent Peyrin‐biroulet
PY - 2026
DA - 2026/09/04
JO - Journal of Clinical Medicine
DO - 10.3390/jcm11154269
UR - https://hal.univ-lorraine.fr/hal-04167942v1
AB - Up to 60% of inflammatory bowel disease (IBD) patients experience abdominal pain in their lifetime regardless of disease activity. Pain negatively affects different areas of daily life and particularly impacts the quality of life of IBD patients. This review provides a comprehensive overview of the multifactorial etiology implicated in the chronic abdominal pain of IBD patients including peripheral sensitization by inflammation, coexistent irritable bowel syndrome, visceral hypersensitivity, alteration of the brain–gut axis, and the multiple factors contributing to pain persistence. Despite the optimal management of intestinal inflammation, chronic abdominal pain can persist, and pharmacological and non-pharmacological approaches are necessary. Integrating psychological support in care models in IBD could decrease disease burden and health care costs. Consequently, a multidisciplinary approach similar to that used for other chronic pain conditions should be recommended.
SN - 2077-0383
ER -