Long-term Prognostic Value of Stress Phase Entropy for Predicting Major Cardiac Events in Patients with Known or Suspected Coronary Artery Disease
Abstract
Tc-tetrofosmin electrocardiogram-gated (ECG)-gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI).Results During the follow-up, 293 patients (13%) experienced MCEs. A multivariate analysis showed that age, the summed difference score, estimated glomerular filtration rate, stress LV ejection fraction (EF), and stress entropy were independent predictors of MCEs. A Kaplan-Meier analysis showed significant risk stratification between each group in the stress phase entropy tertiles. The global chi-squared value predicting MCE onset was significantly improved in the model with the summed stress score and stress LVEF plus entropy, but it was comparable in the model with added bandwidth or phase SD.Conclusion Stress phase entropy derived from ECG-gated SPECT MPI was a strong long-term predictor of MCEs in Japanese patients with CAD (known or suspected) and it is considered to be the most useful left ventricular dyssynchrony index to improve risk stratification over prediction by perfusion and LVEF assessment alone.
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BibTeX
@article{fukumoto2026longterm,
title = {{Long-term Prognostic Value of Stress Phase Entropy for Predicting Major Cardiac Events in Patients with Known or Suspected Coronary Artery Disease}},
author = {Katsunori Fukumoto and Shunichi Yoda and Yudai Tanaka and Tokio Nishiwaki and Takumi Hatta and Yasuyuki Suzuki and Naoya Matsumoto and Yasuo Okumura},
journal = {Internal Medicine},
year = {2026},
month = sep,
doi = {10.2169/internalmedicine.7881-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7881-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Long-term Prognostic Value of Stress Phase Entropy for Predicting Major Cardiac Events in Patients with Known or Suspected Coronary Artery Disease
AU - Katsunori Fukumoto
AU - Shunichi Yoda
AU - Yudai Tanaka
AU - Tokio Nishiwaki
AU - Takumi Hatta
AU - Yasuyuki Suzuki
AU - Naoya Matsumoto
AU - Yasuo Okumura
PY - 2026
DA - 2026/09/15
JO - Internal Medicine
DO - 10.2169/internalmedicine.7881-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7881-26/_article
AB - Tc-tetrofosmin electrocardiogram-gated (ECG)-gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI).Results During the follow-up, 293 patients (13%) experienced MCEs. A multivariate analysis showed that age, the summed difference score, estimated glomerular filtration rate, stress LV ejection fraction (EF), and stress entropy were independent predictors of MCEs. A Kaplan-Meier analysis showed significant risk stratification between each group in the stress phase entropy tertiles. The global chi-squared value predicting MCE onset was significantly improved in the model with the summed stress score and stress LVEF plus entropy, but it was comparable in the model with added bandwidth or phase SD.Conclusion Stress phase entropy derived from ECG-gated SPECT MPI was a strong long-term predictor of MCEs in Japanese patients with CAD (known or suspected) and it is considered to be the most useful left ventricular dyssynchrony index to improve risk stratification over prediction by perfusion and LVEF assessment alone.
SN - 1349-7235
SN - 0918-2918
ER -