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Peer-reviewedCC BYClinical case reports

Massive Pericardial Effusion as a Manifestation of Severe Autoimmune Hypothyroidism in an Adolescent With Down Syndrome: Importance of Early Recognition and Thyroid Hormone Replacement.

  • Bivek Mishra1
  • Pujan Pokharel1
  • Abinash Karki2
  • Oshin Rimal3
  • Ayush Bakhrel4
  • Diwakar Koirala5
  • Ramesh Sapkota5
5 affiliations
  1. 1Department of General Practice and Emergency Medicine B.P Koirala Institute of Health Sciences Dharan Nepal.
  2. 2Department of Cardiology B.P Koirala Institute of Health Sciences Dharan Nepal.
  3. 3Birat Medical College and Teaching Hospital Tankisinuwari Nepal.
  4. 4Department Internal Medicine B.P Koirala Institute of Health Sciences Dharan Nepal.
  5. 5B.P Koirala Institute of Health Sciences Dharan Nepal.
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Abstract

The clinical features of severe hypothyroidism may overlap with those of Down syndrome, delaying diagnosis until complications such as myxedema crisis and massive pericardial effusion develop. Regular thyroid function screening is essential, and hypothyroidism-associated massive pericardial effusion can often be treated conservatively with levothyroxine in the absence of cardiac tamponade.

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Cite

BibTeXRIS
BibTeX
@article{mishra2026massive,
  title = {{Massive Pericardial Effusion as a Manifestation of Severe Autoimmune Hypothyroidism in an Adolescent With Down Syndrome: Importance of Early Recognition and Thyroid Hormone Replacement.}},
  author = {Bivek Mishra and Pujan Pokharel and Abinash Karki and Oshin Rimal and Ayush Bakhrel and Diwakar Koirala and Ramesh Sapkota},
  journal = {Clinical case reports},
  year = {2026},
  month = oct,
  doi = {10.1002/ccr3.73795},
  url = {https://europepmc.org/article/MED/42926915},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Massive Pericardial Effusion as a Manifestation of Severe Autoimmune Hypothyroidism in an Adolescent With Down Syndrome: Importance of Early Recognition and Thyroid Hormone Replacement.
AU  - Bivek Mishra
AU  - Pujan Pokharel
AU  - Abinash Karki
AU  - Oshin Rimal
AU  - Ayush Bakhrel
AU  - Diwakar Koirala
AU  - Ramesh Sapkota
PY  - 2026
DA  - 2026/10/24
JO  - Clinical case reports
DO  - 10.1002/ccr3.73795
UR  - https://europepmc.org/article/MED/42926915
AB  - The clinical features of severe hypothyroidism may overlap with those of Down syndrome, delaying diagnosis until complications such as myxedema crisis and massive pericardial effusion develop. Regular thyroid function screening is essential, and hypothyroidism-associated massive pericardial effusion can often be treated conservatively with levothyroxine in the absence of cardiac tamponade.
SN  - 2050-0904
ER  -