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PreprintCC BY-NC-NDmedRxiv

Memory Intraindividual Variability and its Association with Hippocampal Integrity in Older Latino Adults Without Dementia

  • A. I. Gonzalez1
  • C. Tristao-Pereira
  • L. Martinez
  • N. J. Ramirez
  • G. Aquilino Silva
  • J. Alcina
  • J. E. Martinez
  • A. Giudicessi
  • V. Ku
  • M. C. Rowe
  • L. A. Ramirez-Gomez
  • D. G. Saldana
1 more authors
  • Y. T. Quiroz
  1. 1Department of Psychological & Brain Sciences, Boston University, Boston, Massachusetts, USA
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Abstract

IntroductionCognitive intraindividual variability (IIV), a measure of fluctuation in performance across time or tasks, is an emerging marker of cognitive decline. However, little is known about within-domain IIV in Latino adults. To address this gap, we examined memory IIV and hippocampal integrity in older Latino individuals.

MethodsSixty-seven participants from the Boston Latino Aging Study underwent cognitive testing and MRI. Linear regressions assessed whether memory IIV was associated with hippocampal volume and hippocampus-cingulum tract fractional anisotropy. Additional analyses evaluated associations using mean memory performance as the outcome.

ResultsHigher mean performance was associated with greater hippocampal volume ({beta}=0.24, p=.03), while memory IIV was not ({beta}=0.028, p=.84). Higher memory IIV was associated with lower fractional anisotropy in the hippocampus-cingulum tract ({beta}=-0.34, p<.01), while mean performance was not ({beta}=-0.07, p=.52).

DiscussionMemory IIV may be more closely linked to hippocampal white matter, while mean memory performance may better reflect hippocampal volume.

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Cite

BibTeXRIS
BibTeX
@misc{gonzalez2026memory,
  title = {{Memory Intraindividual Variability and its Association with Hippocampal Integrity in Older Latino Adults Without Dementia}},
  author = {A. I. Gonzalez and C. Tristao-Pereira and L. Martinez and N. J. Ramirez and G. Aquilino Silva and J. Alcina and J. E. Martinez and A. Giudicessi and V. Ku and M. C. Rowe and L. A. Ramirez-Gomez and D. G. Saldana and Y. T. Quiroz},
  howpublished = {medRxiv},
  year = {2026},
  month = oct,
  doi = {10.64898/2026.10.15.26365658},
  url = {https://www.medrxiv.org/content/10.64898/2026.10.15.26365658v1},
  note = {CC BY-NC-ND},
}
RIS
TY  - UNPB
TI  - Memory Intraindividual Variability and its Association with Hippocampal Integrity in Older Latino Adults Without Dementia
AU  - A. I. Gonzalez
AU  - C. Tristao-Pereira
AU  - L. Martinez
AU  - N. J. Ramirez
AU  - G. Aquilino Silva
AU  - J. Alcina
AU  - J. E. Martinez
AU  - A. Giudicessi
AU  - V. Ku
AU  - M. C. Rowe
AU  - L. A. Ramirez-Gomez
AU  - D. G. Saldana
AU  - Y. T. Quiroz
PY  - 2026
DA  - 2026/10/15
PB  - medRxiv
DO  - 10.64898/2026.10.15.26365658
UR  - https://www.medrxiv.org/content/10.64898/2026.10.15.26365658v1
AB  - IntroductionCognitive intraindividual variability (IIV), a measure of fluctuation in performance across time or tasks, is an emerging marker of cognitive decline. However, little is known about within-domain IIV in Latino adults. To address this gap, we examined memory IIV and hippocampal integrity in older Latino individuals.  MethodsSixty-seven participants from the Boston Latino Aging Study underwent cognitive testing and MRI. Linear regressions assessed whether memory IIV was associated with hippocampal volume and hippocampus-cingulum tract fractional anisotropy. Additional analyses evaluated associations using mean memory performance as the outcome.  ResultsHigher mean performance was associated with greater hippocampal volume ({beta}=0.24, p=.03), while memory IIV was not ({beta}=0.028, p=.84). Higher memory IIV was associated with lower fractional anisotropy in the hippocampus-cingulum tract ({beta}=-0.34, p<.01), while mean performance was not ({beta}=-0.07, p=.52).  DiscussionMemory IIV may be more closely linked to hippocampal white matter, while mean memory performance may better reflect hippocampal volume.
ER  -