Genotypes in the 17q12-q21 asthma risk locus and early-life viral wheezing illnesses
Abstract
Genotypes in the 17q12-q21 asthma risk locus and early-life viral wheezing illnessesTo the Editor, Infections with rhinovirus (RV) or respiratory syncytial virus (RSV) are the two most common triggers of wheezing illnesses in preschoolers.These illnesses are leading causes of hospitalization in the early years and also represent a significant risk factor for developing childhood asthma.1,2 While lower respiratory illnesses caused by RSV are preventable, there are no vaccines or antivirals available for RVs.This therapeutic gap highlights the critical need to identify the pathogenic mechanisms behind virus-induced wheezing illnesses and to develop new strategies for treatment or prevention.Genetic, environmental, and personal factors contribute to the risk of preschool wheezing illnesses.These include genes that regulate immune responses and cell-surface receptors utilized by viruses.A genomic region on chromosome 17q12-q21, which encodes the genes ORMDL3 and GSDMB, significantly increases the risk for viral wheeze.3 Interestingly, this region is also the most significant and replicated locus for childhood-onset asthma, 4,5 especially in children with a history of wheeze 6 and/or RV wheeze.3 In a combined editing.Tina V. Hartert: Data curation; writing -review and editing.
Related
- Assessment of wheezing frequency and viral etiology on childhood and adolescent asthma risk
- Effects of Omalizumab on Rhinovirus Infections, Illnesses, and Exacerbations of Asthma
- Rhinovirus species and clinical characteristics in the first wheezing episode in children
- Pulmonary function and bronchial reactivity 4 years after the first virus-induced wheezing
- Rhinovirus C Is Associated With Severe Wheezing and Febrile Respiratory Illness in Young Children
BibTeX
@article{schoettler2026genotypes,
title = {{Genotypes in the 17q12-q21 asthma risk locus and early-life viral wheezing illnesses}},
author = {N. Schoettler and T. Gebretsadik and S. Singh and L. Gress and E. A. Mendonça and B. M. Snyder and A. A. Eapen and P. Lebeau and R. Gangnon and C. M. Seroogy and L. B. Bacharier and Jr. Lemanske and S. V. Lynch and D. R. Gold and R. L. Miller and D. J. Jackson and G. K. K. Hershey and C. C. Johnson and F. D. Martinez and C. Ober and T. V. Hartert and J. E. Gern},
journal = {Pediatric Allergy and Immunology},
year = {2026},
month = oct,
doi = {10.1111/pai.70165},
url = {https://hal.science/hal-05787896v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - Genotypes in the 17q12-q21 asthma risk locus and early-life viral wheezing illnesses
AU - N. Schoettler
AU - T. Gebretsadik
AU - S. Singh
AU - L. Gress
AU - E. A. Mendonça
AU - B. M. Snyder
AU - A. A. Eapen
AU - P. Lebeau
AU - R. Gangnon
AU - C. M. Seroogy
AU - L. B. Bacharier
AU - Jr. Lemanske
AU - S. V. Lynch
AU - D. R. Gold
AU - R. L. Miller
AU - D. J. Jackson
AU - G. K. K. Hershey
AU - C. C. Johnson
AU - F. D. Martinez
AU - C. Ober
AU - T. V. Hartert
AU - J. E. Gern
PY - 2026
DA - 2026/10/09
JO - Pediatric Allergy and Immunology
DO - 10.1111/pai.70165
UR - https://hal.science/hal-05787896v1
AB - Genotypes in the 17q12-q21 asthma risk locus and early-life viral wheezing illnessesTo the Editor, Infections with rhinovirus (RV) or respiratory syncytial virus (RSV) are the two most common triggers of wheezing illnesses in preschoolers.These illnesses are leading causes of hospitalization in the early years and also represent a significant risk factor for developing childhood asthma.1,2 While lower respiratory illnesses caused by RSV are preventable, there are no vaccines or antivirals available for RVs.This therapeutic gap highlights the critical need to identify the pathogenic mechanisms behind virus-induced wheezing illnesses and to develop new strategies for treatment or prevention.Genetic, environmental, and personal factors contribute to the risk of preschool wheezing illnesses.These include genes that regulate immune responses and cell-surface receptors utilized by viruses.A genomic region on chromosome 17q12-q21, which encodes the genes ORMDL3 and GSDMB, significantly increases the risk for viral wheeze.3 Interestingly, this region is also the most significant and replicated locus for childhood-onset asthma, 4,5 especially in children with a history of wheeze 6 and/or RV wheeze.3 In a combined editing.Tina V. Hartert: Data curation; writing -review and editing.
SN - 0905-6157
SN - 1399-3038
ER -