Thyroid dysfunction in aging and cardiovascular-kidney-metabolic syndrome: metabolic regulation and clinical implications
- 1Health Checkup Center, China-Japan Friendship Hospital
- 2State Key Laboratory of Respiratory Health and Multimorbidity, China-Japan Friendship Hospital
Abstract
Thyroid hormones are involved in multiple metabolic pathways in the body and are essential for maintaining organ functions across the lifespan. Aging-related thyroid dysfunction has a bidirectional relationship with the development of chronic diseases including metabolic syndrome, diabetes, and cardiovascular disease, and contributes to the progression of cardiovascular-kidney-metabolic (CKM) syndrome via complex pathophysiological mechanisms. Systematically elaborating on the characteristics of thyroid function related to aging and its regulatory role in metabolism and cardiovascular homeostasis, can provide new therapeutic strategies and theoretical basis for revealing the molecular network and metabolic process of the CKM syndrome. In this review, we have summarized the manifestations of thyroid hormone homeostasis in age-related changes, and the underlying potential mechanisms during aging and longevity processes. Moreover, we systematically elucidated the pivotal role of thyroid hormones in cardiovascular and renal homeostasis, discussed the interplay between thyroid dysfunction and metabolic risk factors in CKM syndrome, particularly issues related to obesity, type 2 diabetes, and dyslipidemia. Patients with thyroid dysfunction develop CKM syndrome through a positive feedback loop centered on metabolic disorders and organic dysfunction. Moreover, we pointed out that novel drugs targeting thyroid hormone receptors are expected to slow down the progression of CKM syndrome and reduce cardiovascular risks.
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BibTeX
@article{li2026thyroid,
title = {{Thyroid dysfunction in aging and cardiovascular-kidney-metabolic syndrome: metabolic regulation and clinical implications}},
author = {Hui Li and Na Wang and Xianhui Ran and Zhiyuan Fan and Tianyi Zhao and Xiao Ma},
journal = {Frontiers in Endocrinology},
year = {2026},
month = oct,
doi = {10.3389/fendo.2026.2000192},
url = {https://www.frontiersin.org/articles/10.3389/fendo.2026.2000192/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Thyroid dysfunction in aging and cardiovascular-kidney-metabolic syndrome: metabolic regulation and clinical implications
AU - Hui Li
AU - Na Wang
AU - Xianhui Ran
AU - Zhiyuan Fan
AU - Tianyi Zhao
AU - Xiao Ma
PY - 2026
DA - 2026/10/22
JO - Frontiers in Endocrinology
DO - 10.3389/fendo.2026.2000192
UR - https://www.frontiersin.org/articles/10.3389/fendo.2026.2000192/full
AB - Thyroid hormones are involved in multiple metabolic pathways in the body and are essential for maintaining organ functions across the lifespan. Aging-related thyroid dysfunction has a bidirectional relationship with the development of chronic diseases including metabolic syndrome, diabetes, and cardiovascular disease, and contributes to the progression of cardiovascular-kidney-metabolic (CKM) syndrome via complex pathophysiological mechanisms. Systematically elaborating on the characteristics of thyroid function related to aging and its regulatory role in metabolism and cardiovascular homeostasis, can provide new therapeutic strategies and theoretical basis for revealing the molecular network and metabolic process of the CKM syndrome. In this review, we have summarized the manifestations of thyroid hormone homeostasis in age-related changes, and the underlying potential mechanisms during aging and longevity processes. Moreover, we systematically elucidated the pivotal role of thyroid hormones in cardiovascular and renal homeostasis, discussed the interplay between thyroid dysfunction and metabolic risk factors in CKM syndrome, particularly issues related to obesity, type 2 diabetes, and dyslipidemia. Patients with thyroid dysfunction develop CKM syndrome through a positive feedback loop centered on metabolic disorders and organic dysfunction. Moreover, we pointed out that novel drugs targeting thyroid hormone receptors are expected to slow down the progression of CKM syndrome and reduce cardiovascular risks.
SN - 1664-2392
ER -