Early duodenal signet-ring cell carcinoma covered by gastric foveolar metaplasia

Abstract

A 52-year-old man underwent esophagogastroduodenoscopy during a routine health checkup, which revealed a 15 mm semipedunculated lesion in the duodenal bulb. The initial biopsy revealed Brunner's gland hyperplasia with gastric foveolar metaplasia (GFM). A second biopsy performed 6 months later revealed signet-ring cell carcinoma (SRCC) beneath a thick overlying layer of GFM, and endoscopic mucosal resection was thus performed. The carcinoma was confined to the mucosa only. Both the SRCC and the overlying GFM exhibited a gastric-type phenotype, with an in situ lesion identified within the GFM. We report a diagnostically informative case of early duodenal SRCC.

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BibTeX RIS

BibTeX

@article{horiuchi2026early,
  title = {{Early duodenal signet-ring cell carcinoma covered by gastric foveolar metaplasia}},
  author = {Kazuki Horiuchi and Kei Kato},
  journal = {Internal Medicine},
  year = {2026},
  month = jul,
  doi = {10.2169/internalmedicine.7750-26},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7750-26/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Early duodenal signet-ring cell carcinoma covered by gastric foveolar metaplasia
AU  - Kazuki Horiuchi
AU  - Kei Kato
PY  - 2026
DA  - 2026/07/11
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.7750-26
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7750-26/_article
AB  - A 52-year-old man underwent esophagogastroduodenoscopy during a routine health checkup, which revealed a 15 mm semipedunculated lesion in the duodenal bulb. The initial biopsy revealed Brunner's gland hyperplasia with gastric foveolar metaplasia (GFM). A second biopsy performed 6 months later revealed signet-ring cell carcinoma (SRCC) beneath a thick overlying layer of GFM, and endoscopic mucosal resection was thus performed. The carcinoma was confined to the mucosa only. Both the SRCC and the overlying GFM exhibited a gastric-type phenotype, with an in situ lesion identified within the GFM. We report a diagnostically informative case of early duodenal SRCC.
SN  - 1349-7235
SN  - 0918-2918
ER  -

Abstract

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