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Peer-reviewedCC BY-NC-NDJournal of nanobiotechnology

Near-infrared-activated CuTA@PDA@PTH nanozymes remodel the osteoarthritic microenvironment for coordinated cartilage protection and subchondral bone repair.

  • Zhao Lin1,2,3,4,5
  • Jiayao Zhang1,2,3,4,5
  • Mingjuan Zhang1,2,3,4,5
  • Mukun Xiao1,2,3,4,5
  • Hanhao Dai1,2,3,4,5
  • Yibin Su2,6,3,4,5
  • Haiqi Ding1,2,3,4,5
  • Dingqiang Chen1,2,3,4,5
  • Linhai Yang1,2,3,4,5
  • Jie Xu7,8,9,10,11
  • Jun Luo12,13,14,15,16
  • Yunlong Yu17,18,19,20,21
21 affiliations
  1. 1Department of Orthopedics, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.
  2. 2Department of Orthopedics, Fujian Provincial Hospital, School of Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.
  3. 3Fujian Provincial Clinical Research Center for Spinal Nerve and Joint Diseases, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China.
  4. 4Engineering Research Center of Orthopedic Biomaterials, Fujian Province University, Fuzhou University, Fuzhou, Fujian, China.
  5. 5Fujian Provincial Scoliosis Diagnosis and Treatment Center, Fuazhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China.
  6. 6Department of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
  7. 7Department of Orthopedics, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. [email protected].
  8. 8Department of Orthopedics, Fujian Provincial Hospital, School of Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. [email protected].
  9. 9Fujian Provincial Clinical Research Center for Spinal Nerve and Joint Diseases, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China. [email protected].
  10. 10Engineering Research Center of Orthopedic Biomaterials, Fujian Province University, Fuzhou University, Fuzhou, Fujian, China. [email protected].
  11. 11Fujian Provincial Scoliosis Diagnosis and Treatment Center, Fuazhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China. [email protected].
  12. 12Department of Orthopedics, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. [email protected].
  13. 13Department of Orthopedics, Fujian Provincial Hospital, School of Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. [email protected].
  14. 14Fujian Provincial Clinical Research Center for Spinal Nerve and Joint Diseases, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China. [email protected].
  15. 15Engineering Research Center of Orthopedic Biomaterials, Fujian Province University, Fuzhou University, Fuzhou, Fujian, China. [email protected].
  16. 16Fujian Provincial Scoliosis Diagnosis and Treatment Center, Fuazhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China. [email protected].
  17. 17Department of Orthopedics, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. [email protected].
  18. 18Department of Orthopedics, Fujian Provincial Hospital, School of Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. [email protected].
  19. 19Fujian Provincial Clinical Research Center for Spinal Nerve and Joint Diseases, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China. [email protected].
  20. 20Engineering Research Center of Orthopedic Biomaterials, Fujian Province University, Fuzhou University, Fuzhou, Fujian, China. [email protected].
  21. 21Fujian Provincial Scoliosis Diagnosis and Treatment Center, Fuazhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China. [email protected].
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Abstract

Osteoarthritis (OA) is a progressive whole-joint disorder involving cartilage degeneration, oxidative stress, synovial inflammation, and subchondral bone remodeling. Current treatments mainly provide symptomatic relief and rarely restore joint microenvironmental homeostasis. Here, we developed a multifunctional near-infrared (NIR)-responsive CuTA@PDA@PTH nanozyme, termed CPP, for OA therapy. CPP was constructed through copper-tannic acid coordination, polydopamine coating, and PTH 1-34 incorporation, integrating antioxidant catalytic activity, photothermal responsiveness, and peptide-mediated bioactivity. CPP exhibited uniform morphology, good dispersibility, stable photothermal behavior, and broad-spectrum ROS-scavenging activity with SOD-like and CAT-like functions. In vitro, NIR-activated CPP reduced H₂O₂-induced ROS accumulation, lipid peroxidation, mitochondrial dysfunction, and apoptosis in chondrocytes, while promoting proliferation and restoring cartilage matrix homeostasis. CPP-NIR also downregulated inflammatory and catabolic markers, attenuated M1-associated activation, favored an anti-inflammatory M2-like phenotype, and enhanced BMSC migration and osteogenic differentiation under oxidative stress. In a DMM-induced mouse OA model, intra-articular CPP combined with NIR irradiation prolonged joint retention, attenuated cartilage degeneration, reduced osteophyte formation, improved subchondral bone microarchitecture, and alleviated synovial inflammation. These findings support NIR-activated CPP as a multi-axis nanozyme platform for redox, immune, cartilage, and subchondral bone microenvironment regulation in OA.

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Cite

BibTeXRIS
BibTeX
@article{lin2026nearinfraredactivated,
  title = {{Near-infrared-activated CuTA@PDA@PTH nanozymes remodel the osteoarthritic microenvironment for coordinated cartilage protection and subchondral bone repair.}},
  author = {Zhao Lin and Jiayao Zhang and Mingjuan Zhang and Mukun Xiao and Hanhao Dai and Yibin Su and Haiqi Ding and Dingqiang Chen and Linhai Yang and Jie Xu and Jun Luo and Yunlong Yu},
  journal = {Journal of nanobiotechnology},
  year = {2026},
  month = jul,
  doi = {10.1186/s12951-026-04841-0},
  url = {https://europepmc.org/article/MED/42919371},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Near-infrared-activated CuTA@PDA@PTH nanozymes remodel the osteoarthritic microenvironment for coordinated cartilage protection and subchondral bone repair.
AU  - Zhao Lin
AU  - Jiayao Zhang
AU  - Mingjuan Zhang
AU  - Mukun Xiao
AU  - Hanhao Dai
AU  - Yibin Su
AU  - Haiqi Ding
AU  - Dingqiang Chen
AU  - Linhai Yang
AU  - Jie Xu
AU  - Jun Luo
AU  - Yunlong Yu
PY  - 2026
DA  - 2026/07/01
JO  - Journal of nanobiotechnology
DO  - 10.1186/s12951-026-04841-0
UR  - https://europepmc.org/article/MED/42919371
AB  - Osteoarthritis (OA) is a progressive whole-joint disorder involving cartilage degeneration, oxidative stress, synovial inflammation, and subchondral bone remodeling. Current treatments mainly provide symptomatic relief and rarely restore joint microenvironmental homeostasis. Here, we developed a multifunctional near-infrared (NIR)-responsive CuTA@PDA@PTH nanozyme, termed CPP, for OA therapy. CPP was constructed through copper-tannic acid coordination, polydopamine coating, and PTH 1-34 incorporation, integrating antioxidant catalytic activity, photothermal responsiveness, and peptide-mediated bioactivity. CPP exhibited uniform morphology, good dispersibility, stable photothermal behavior, and broad-spectrum ROS-scavenging activity with SOD-like and CAT-like functions. In vitro, NIR-activated CPP reduced H₂O₂-induced ROS accumulation, lipid peroxidation, mitochondrial dysfunction, and apoptosis in chondrocytes, while promoting proliferation and restoring cartilage matrix homeostasis. CPP-NIR also downregulated inflammatory and catabolic markers, attenuated M1-associated activation, favored an anti-inflammatory M2-like phenotype, and enhanced BMSC migration and osteogenic differentiation under oxidative stress. In a DMM-induced mouse OA model, intra-articular CPP combined with NIR irradiation prolonged joint retention, attenuated cartilage degeneration, reduced osteophyte formation, improved subchondral bone microarchitecture, and alleviated synovial inflammation. These findings support NIR-activated CPP as a multi-axis nanozyme platform for redox, immune, cartilage, and subchondral bone microenvironment regulation in OA.
SN  - 1477-3155
ER  -