Evaluation of Peripapillary Vitreous Dynamics in Patients with Acute Nonarteritic Anterior Ischemic Optic Neuropathy
- 1University of Health Sciences Türkiye Ankara Training and Research Hospital, Clinic of Ophthalmology, Ankara, Türkiye
Abstract
Objectives: To evaluate peripapillary and vitreomacular interface configurations using spectral-domain optical coherence tomography (SD-OCT) in patients with acute nonarteritic anterior ischemic optic neuropathy (NAION) and to compare findings with age-matched controls.
Materials and Methods: This single-center, retrospective, observational study included 60 patients with acute NAION and 60 age- and sex-matched healthy controls. Circumpapillary retinal nerve fiber layer scans and macular SD-OCT images were analyzed. Assessed peripapillary vitreoretinal interface parameters included peripapillary vitreoretinal adhesion, vitreoretinal traction, complete peripapillary vitreous detachment, peripapillary folds, superficial vascular protrusions, and hyperreflective vitreous dots. Vitreomacular interface characteristics were also evaluated.
Results: Peripapillary vitreoretinal adhesion was more frequently observed in NAION eyes compared with controls (50% vs. 25%, p=0.04). Hyperreflective vitreous dots were significantly more common in NAION eyes (68.3% vs. 8.3%; p<0.001), with a higher mean count (5.31±6.05 vs. 0.50±1.54; p<0.001). Peripapillary folds were also more prevalent in NAION (41.7% vs. 1.7%; p<0.001). Although peripapillary superficial vascular protrusions were common in both groups, mean counts differed significantly (p<0.001). Among 34 NAION eyes with longitudinal follow-up, 29.4% demonstrated interval changes in vitreoretinal interface configuration.
Conclusion: Acute NAION is associated with distinct peripapillary vitreoretinal interface characteristics detectable by SD-OCT. These findings highlight structural differences in vitreoretinal interface configuration in acute NAION. However, their temporal relationship to ischemic injury remains uncertain.
Related
- Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy: Notoriety Bias or True Ocular Toxicity?
- Application of a multimodal model integrating optical coherence tomography angiography (OCTA) and radiomics for the identification of high-risk Nonarteritic anterior ischaemic optic neuropathy (NAION) populations and for distinguishing its acute phase.
- Unilateral nonarteritic anterior ischemic optic neuropathy associated with obstructive sleep apnea-hypopnea syndrome: a case report.
- Diabetic Retinal Disease Onset and Progression During Established Semaglutide or Tirzepatide Treatment: A Retrospective Comparative Cohort Study With a Descriptive Regional Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Review.
- Evaluation of the efficacy of duloxetine and venlafaxine in chemotherapy-induced neuropathy in cancer patients: a double-blind multicenter randomized clinical trial
BibTeX
@article{orman2026evaluation,
title = {{Evaluation of Peripapillary Vitreous Dynamics in Patients with Acute Nonarteritic Anterior Ischemic Optic Neuropathy}},
author = {Gözde Orman and Özlem Candan and Kübra Küçükiba and Gülten Sungur and Nurten Ünlü and Ayşe Burcu},
journal = {Turkish Journal of Ophthalmology},
year = {2026},
month = oct,
doi = {10.4274/tjo.galenos.2026.62254},
url = {https://doi.org/10.4274/tjo.galenos.2026.62254},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Evaluation of Peripapillary Vitreous Dynamics in Patients with Acute Nonarteritic Anterior Ischemic Optic Neuropathy
AU - Gözde Orman
AU - Özlem Candan
AU - Kübra Küçükiba
AU - Gülten Sungur
AU - Nurten Ünlü
AU - Ayşe Burcu
PY - 2026
DA - 2026/10/01
JO - Turkish Journal of Ophthalmology
DO - 10.4274/tjo.galenos.2026.62254
UR - https://doi.org/10.4274/tjo.galenos.2026.62254
AB - Objectives: To evaluate peripapillary and vitreomacular interface configurations using spectral-domain optical coherence tomography (SD-OCT) in patients with acute nonarteritic anterior ischemic optic neuropathy (NAION) and to compare findings with age-matched controls. Materials and Methods: This single-center, retrospective, observational study included 60 patients with acute NAION and 60 age- and sex-matched healthy controls. Circumpapillary retinal nerve fiber layer scans and macular SD-OCT images were analyzed. Assessed peripapillary vitreoretinal interface parameters included peripapillary vitreoretinal adhesion, vitreoretinal traction, complete peripapillary vitreous detachment, peripapillary folds, superficial vascular protrusions, and hyperreflective vitreous dots. Vitreomacular interface characteristics were also evaluated. Results: Peripapillary vitreoretinal adhesion was more frequently observed in NAION eyes compared with controls (50% vs. 25%, p=0.04). Hyperreflective vitreous dots were significantly more common in NAION eyes (68.3% vs. 8.3%; p<0.001), with a higher mean count (5.31±6.05 vs. 0.50±1.54; p<0.001). Peripapillary folds were also more prevalent in NAION (41.7% vs. 1.7%; p<0.001). Although peripapillary superficial vascular protrusions were common in both groups, mean counts differed significantly (p<0.001). Among 34 NAION eyes with longitudinal follow-up, 29.4% demonstrated interval changes in vitreoretinal interface configuration. Conclusion: Acute NAION is associated with distinct peripapillary vitreoretinal interface characteristics detectable by SD-OCT. These findings highlight structural differences in vitreoretinal interface configuration in acute NAION. However, their temporal relationship to ischemic injury remains uncertain.
SN - 2149-8695
SN - 2149-8709
ER -