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Peer-reviewedCC BYScientific Reports

Dermoscopy guided high-frequency ultrasound features of basal cell carcinoma subtypes compared with histopathology: a multicenter study

  • Mehdi Boostani1
  • Florencia Vera Morandini2
  • Ximena Wortsman3
  • Cristian Navarrete-Dechent4
  • Javiera Pérez-Anker2
  • Priscila Giavedoni2
  • Noah Goldfarb5
  • Manu Jain6
  • Lucas Boussingault7
  • Tara Kiss1
  • Philippe Bahadoran8
  • Kamran Avanaki9
8 more authors
  • András Bánvölgyi1
  • Kende Lőrincz1
  • Norbert M. Wikonkál1
  • Veronique Del Marmol7
  • Mariano Suppa7
  • Josep Malvehy2
  • Gyorgy Paragh10
  • Norbert Kiss1
10 affiliations
  1. 1Department of Dermatology, Venereology and Dermatooncology, Semmelweis University
  2. 2Department of Dermatology, Hospital Clínic de Barcelona, Universitat de Barcelona
  3. 3Department of Dermatology, Faculty of Medicine, Universidad de Chile
  4. 4Department of Dermatology, Escuela de Medicina, Pontificia Universidad Catolica de Chile
  5. 5Departments of Medicine and Dermatology, University of Minnesota
  6. 6Dermatology Service, Memorial Sloan Kettering Cancer Center
  7. 7Department of Dermatology, Hôpital Erasme, Université Libre de Bruxelles
  8. 8Department of Dermatology, University Côte d’Azur. Centre Hospitalier Universitaire de Nice (CHU)
  9. 9Department of Biomedical Engineering, Richard and Loan Hill, University of Illinois at Chicago
  10. 10Department of Dermatology, Roswell Park Comprehensive Cancer Center
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Abstract

Accurate non-invasive differentiation of basal cell carcinoma (BCC) subtypes is crucial for guiding treatment; however, current imaging tools have limitations in accessibility, depth resolution, and interpretability. To describe sonographic features of distinct BCC subtypes using dermoscopy-guided high-frequency ultrasound (DG-HFUS), and assess its potential as a non-invasive subtyping modality. In this multicenter cross-sectional study, 87 histologically confirmed BCCs (nodular, superficial, infiltrative, and micronodular) were imaged using a portable 33 MHz DG-HFUS device. Morphological features were evaluated independently by blinded observers, and statistical associations with histologic subtypes were analyzed using univariate logistic regression. Hypoechoic mass was the most common sonographic feature of BCCs, seen in 92% of cases. Distinct DG-HFUS features correlated with specific subtypes: ribbon-like shape (OR = 86.3, p < 0.0001), homogeneous internal echoes (OR = 22.5, p = 0.003), and well-defined margins (OR = 9, p = 0.04) were strongly associated with superficial BCC; oval shape (OR = 3.8, p = 0.003) and prominent hyperechoic spots (OR = 3.5, p = 0.005) with nodular BCC; and acoustic shadowing (OR = 7.5, p = 0.001) with infiltrative BCC. Micronodular BCCs were underrepresented. Mixed subtypes were excluded, and vascular patterns were not evaluated. DG-HFUS reveals subtype-specific sonographic features and offers a promising, accessible, and interpretable tool for non-invasive BCC classification in clinical settings.

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Cite

BibTeXRIS
BibTeX
@article{boostani2026dermoscopy,
  title = {{Dermoscopy guided high-frequency ultrasound features of basal cell carcinoma subtypes compared with histopathology: a multicenter study}},
  author = {Mehdi Boostani and Florencia Vera Morandini and Ximena Wortsman and Cristian Navarrete-Dechent and Javiera Pérez-Anker and Priscila Giavedoni and Noah Goldfarb and Manu Jain and Lucas Boussingault and Tara Kiss and Philippe Bahadoran and Kamran Avanaki and András Bánvölgyi and Kende Lőrincz and Norbert M. Wikonkál and Veronique Del Marmol and Mariano Suppa and Josep Malvehy and Gyorgy Paragh and Norbert Kiss},
  journal = {Scientific Reports},
  year = {2026},
  month = jul,
  doi = {10.1038/s41598-026-62657-2},
  url = {https://doi.org/10.1038/s41598-026-62657-2},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Dermoscopy guided high-frequency ultrasound features of basal cell carcinoma subtypes compared with histopathology: a multicenter study
AU  - Mehdi Boostani
AU  - Florencia Vera Morandini
AU  - Ximena Wortsman
AU  - Cristian Navarrete-Dechent
AU  - Javiera Pérez-Anker
AU  - Priscila Giavedoni
AU  - Noah Goldfarb
AU  - Manu Jain
AU  - Lucas Boussingault
AU  - Tara Kiss
AU  - Philippe Bahadoran
AU  - Kamran Avanaki
AU  - András Bánvölgyi
AU  - Kende Lőrincz
AU  - Norbert M. Wikonkál
AU  - Veronique Del Marmol
AU  - Mariano Suppa
AU  - Josep Malvehy
AU  - Gyorgy Paragh
AU  - Norbert Kiss
PY  - 2026
DA  - 2026/07/01
JO  - Scientific Reports
DO  - 10.1038/s41598-026-62657-2
UR  - https://doi.org/10.1038/s41598-026-62657-2
AB  - Accurate non-invasive differentiation of basal cell carcinoma (BCC) subtypes is crucial for guiding treatment; however, current imaging tools have limitations in accessibility, depth resolution, and interpretability. To describe sonographic features of distinct BCC subtypes using dermoscopy-guided high-frequency ultrasound (DG-HFUS), and assess its potential as a non-invasive subtyping modality. In this multicenter cross-sectional study, 87 histologically confirmed BCCs (nodular, superficial, infiltrative, and micronodular) were imaged using a portable 33 MHz DG-HFUS device. Morphological features were evaluated independently by blinded observers, and statistical associations with histologic subtypes were analyzed using univariate logistic regression. Hypoechoic mass was the most common sonographic feature of BCCs, seen in 92% of cases. Distinct DG-HFUS features correlated with specific subtypes: ribbon-like shape (OR = 86.3, p < 0.0001), homogeneous internal echoes (OR = 22.5, p = 0.003), and well-defined margins (OR = 9, p = 0.04) were strongly associated with superficial BCC; oval shape (OR = 3.8, p = 0.003) and prominent hyperechoic spots (OR = 3.5, p = 0.005) with nodular BCC; and acoustic shadowing (OR = 7.5, p = 0.001) with infiltrative BCC. Micronodular BCCs were underrepresented. Mixed subtypes were excluded, and vascular patterns were not evaluated. DG-HFUS reveals subtype-specific sonographic features and offers a promising, accessible, and interpretable tool for non-invasive BCC classification in clinical settings.
SN  - 2045-2322
ER  -