Peer-reviewedCC BY-NC-NDInternal Medicine
Transcatheter Mitral Edge-to-edge Repair in Patients with Transthyretin Cardiac Amyloidosis: A Four-case Series
Abstract
Cardiac amyloidosis is characterized by the deposition of amyloid fibrils, which cause complications such as mitral regurgitation (MR). The efficacy of transcatheter mitral edge-to-edge mitral repair (TEER) in patients with amyloidosis remains uncertain. We herein present four cases of TEER for transthyretin cardiac amyloidosis. TEER reduced the MR in all cases. However, two of the four individuals died within one year, and in one case, a recurrent MR deterioration occurred. Although TEER can reduce MR in individuals with cardiac amyloidosis, the long-term outcomes appear to be poor owing to disease progression or comorbidities, thereby underscoring the need for careful patient selection.
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BibTeX
@article{ujita2026transcatheter,
title = {{Transcatheter Mitral Edge-to-edge Repair in Patients with Transthyretin Cardiac Amyloidosis: A Four-case Series}},
author = {Ayaka Ujita and Masayoshi Yamamoto and Tomoya Hoshi and Kentaro Minami and Yu Yamada and Kimi Sato and Tomoko Machino-Ohtsuka and Tomoko Ishizu},
journal = {Internal Medicine},
year = {2026},
month = sep,
doi = {10.2169/internalmedicine.6425-25},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/17/65_6425-25/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Transcatheter Mitral Edge-to-edge Repair in Patients with Transthyretin Cardiac Amyloidosis: A Four-case Series
AU - Ayaka Ujita
AU - Masayoshi Yamamoto
AU - Tomoya Hoshi
AU - Kentaro Minami
AU - Yu Yamada
AU - Kimi Sato
AU - Tomoko Machino-Ohtsuka
AU - Tomoko Ishizu
PY - 2026
DA - 2026/09/01
JO - Internal Medicine
DO - 10.2169/internalmedicine.6425-25
UR - https://www.jstage.jst.go.jp/article/internalmedicine/65/17/65_6425-25/_article
AB - Cardiac amyloidosis is characterized by the deposition of amyloid fibrils, which cause complications such as mitral regurgitation (MR). The efficacy of transcatheter mitral edge-to-edge mitral repair (TEER) in patients with amyloidosis remains uncertain. We herein present four cases of TEER for transthyretin cardiac amyloidosis. TEER reduced the MR in all cases. However, two of the four individuals died within one year, and in one case, a recurrent MR deterioration occurred. Although TEER can reduce MR in individuals with cardiac amyloidosis, the long-term outcomes appear to be poor owing to disease progression or comorbidities, thereby underscoring the need for careful patient selection.
SN - 1349-7235
SN - 0918-2918
ER -