Skip to content
DraconiticResearch
Search Sources API
203,203 studies31 sourcesUpdated 52 min ago
PreprintCC BY 4.0arXiv

Hydrodynamic flow in the gut hinders the fixation of beneficial mutants but accelerates their invasion

  • Arthur Alexandre
  • Claude Loverdo
  • Anne-Florence Bitbol
Open at sourcePDFDOICite

Abstract

Gut bacteria experience a spatially structured environment with hydrodynamic flow. Using a branching-process approach, we show that beneficial mutants arising randomly upon division have a reduced fixation probability compared to the well-mixed case. The suppression factor is set by the spatial heterogeneity of mutant fate across the gut. In contrast, the invasion of mutant lineages that avoid early stochastic extinction is accelerated in the gut compared to a matched well-mixed case. Stronger advective flow decreases fixation probabilities while accelerating mutant invasion.

Related

  1. BMP2, transcriptionally regulated by GATA6, accelerates the proliferation and invasion of lung squamous carcinoma cells
    Hua Yang, Changhua Huang, Hailong Wang +1
    iSciencePeer-reviewedCC BY-NC-ND 4.0Full textCell biologyCell PressCrossrefPMCEurope PMC
  2. Hydrodynamic theories of chemotaxis-driven invasion in proliferating cell populations
    Giulia L. Celora, Martina Conte
    arXivPreprintCC BY 4.0Full textCell biologyarXiv
  3. 772 TOX maintains T cell exhaustion and hinders the development of tumor-specific CD8+ T cell memory
    Creg Workman, Erin Brunazzi, Dario AA Vignali +1
    Journal for ImmunoTherapy of CancerPeer-reviewedCC BYFull textImmunologyDOAJ
  4. Establishing genetic tractability in Jeongeupia sacculi HS-3: disruption of rpoS hinders biofilm formation
    Z. Beddingfield, I. K. Calimlim, C. Zhang +1
    bioRxivPreprintCC BYFull textMicrobiologybioRxiv
  5. Conditional myeloid-specific deletion of Ube2n hinders YUMM1.7 melanoma growth.
    Kelsie Schiavone, Adam Pecoraro, Afsa Khawar +5
    Frontiers in oncologyPeer-reviewedCC BYFull textImmunologyEurope PMC

Cite

BibTeXRIS
BibTeX
@misc{alexandre2026hydrodynamic,
  title = {{Hydrodynamic flow in the gut hinders the fixation of beneficial mutants but accelerates their invasion}},
  author = {Arthur Alexandre and Claude Loverdo and Anne-Florence Bitbol},
  howpublished = {arXiv},
  year = {2026},
  month = nov,
  doi = {10.48550/arxiv.2611.00134},
  eprint = {2611.00134},
  archivePrefix = {arXiv},
  url = {https://arxiv.org/abs/2611.00134},
  note = {CC BY 4.0},
}
RIS
TY  - UNPB
TI  - Hydrodynamic flow in the gut hinders the fixation of beneficial mutants but accelerates their invasion
AU  - Arthur Alexandre
AU  - Claude Loverdo
AU  - Anne-Florence Bitbol
PY  - 2026
DA  - 2026/11/01
PB  - arXiv
DO  - 10.48550/arxiv.2611.00134
UR  - https://arxiv.org/abs/2611.00134
AB  - Gut bacteria experience a spatially structured environment with hydrodynamic flow. Using a branching-process approach, we show that beneficial mutants arising randomly upon division have a reduced fixation probability compared to the well-mixed case. The suppression factor is set by the spatial heterogeneity of mutant fate across the gut. In contrast, the invasion of mutant lineages that avoid early stochastic extinction is accelerated in the gut compared to a matched well-mixed case. Stronger advective flow decreases fixation probabilities while accelerating mutant invasion.
ER  -