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Peer-reviewedCC BY 4.0Cells

Selenium-Enriched Rapeseed Extract Synergizes with Chemotherapy Drug Cisplatin in Inhibiting Proliferation and Promoting Apoptosis of Colorectal Cancer Cells

  • Xiaofei Duan1
  • Yiqing Lu1
  • Hongyu Zhou1
  • Zi Zhang1
  • Zhanan Zhou1
  • Miao Wang1
  • Zhenna Chen2
  • Xiaoling Dun2
  • Yang Zhu1
  • Hanzhong Wang2,3
  • Lixi Jiang1
  1. 1Institute of Crop Science, Zhejiang University, Hangzhou 310058, China
  2. 2Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture and Rural Affairs, Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Wuhan 430062, China
  3. 3Hubei Hongshan Laboratory, Wuhan 430070, China
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Abstract

Chemotherapy treatment of colorectal cancer (CRC) with cisplatin (CDDP) faces drug resistance and cytotoxicity issues, highlighting the urgent need for combination strategies. Selenium-enriched rapeseed extracts exhibit anticancer effects; however, their bioactive components and mechanisms remain unclear. Here, we applied different solvents to fractionate extracts of selenium-enriched rapeseed and found that the water extract (WE) fraction significantly enhanced the cytotoxic effect of CDDP on cancer cells without damaging normal cells, namely, HK-2 and NCM460. High-performance liquid chromatography–inductively coupled plasma–mass spectrometry (HPLC-ICP-MS) analysis revealed methylselenocysteine (MSC) and selenocysteine (SeCys2) as the main selenium species in the WE. Through cell biology and integrative multi-omics analysis, we found a synergistic anti-CRC cell effect upon combining CDDP with MSC, sulforaphane (SFN), celastrol (Cel), indole-3-carbinol (I3C), α-linolenic acid (ALA) or linoleic acid (LA). We propose that CDDP-WE (cisplatin and water extract) combination treatment holds promise for improving antitumor efficacy against chemo-refractory cells.

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Cite

BibTeXRIS
BibTeX
@article{duan2026seleniumenriched,
  title = {{Selenium-Enriched Rapeseed Extract Synergizes with Chemotherapy Drug Cisplatin in Inhibiting Proliferation and Promoting Apoptosis of Colorectal Cancer Cells}},
  author = {Xiaofei Duan and Yiqing Lu and Hongyu Zhou and Zi Zhang and Zhanan Zhou and Miao Wang and Zhenna Chen and Xiaoling Dun and Yang Zhu and Hanzhong Wang and Lixi Jiang},
  journal = {Cells},
  year = {2026},
  month = oct,
  doi = {10.3390/cells15211934},
  url = {https://www.mdpi.com/2073-4409/15/21/1934},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Selenium-Enriched Rapeseed Extract Synergizes with Chemotherapy Drug Cisplatin in Inhibiting Proliferation and Promoting Apoptosis of Colorectal Cancer Cells
AU  - Xiaofei Duan
AU  - Yiqing Lu
AU  - Hongyu Zhou
AU  - Zi Zhang
AU  - Zhanan Zhou
AU  - Miao Wang
AU  - Zhenna Chen
AU  - Xiaoling Dun
AU  - Yang Zhu
AU  - Hanzhong Wang
AU  - Lixi Jiang
PY  - 2026
DA  - 2026/10/24
JO  - Cells
DO  - 10.3390/cells15211934
UR  - https://www.mdpi.com/2073-4409/15/21/1934
AB  - Chemotherapy treatment of colorectal cancer (CRC) with cisplatin (CDDP) faces drug resistance and cytotoxicity issues, highlighting the urgent need for combination strategies. Selenium-enriched rapeseed extracts exhibit anticancer effects; however, their bioactive components and mechanisms remain unclear. Here, we applied different solvents to fractionate extracts of selenium-enriched rapeseed and found that the water extract (WE) fraction significantly enhanced the cytotoxic effect of CDDP on cancer cells without damaging normal cells, namely, HK-2 and NCM460. High-performance liquid chromatography–inductively coupled plasma–mass spectrometry (HPLC-ICP-MS) analysis revealed methylselenocysteine (MSC) and selenocysteine (SeCys2) as the main selenium species in the WE. Through cell biology and integrative multi-omics analysis, we found a synergistic anti-CRC cell effect upon combining CDDP with MSC, sulforaphane (SFN), celastrol (Cel), indole-3-carbinol (I3C), α-linolenic acid (ALA) or linoleic acid (LA). We propose that CDDP-WE (cisplatin and water extract) combination treatment holds promise for improving antitumor efficacy against chemo-refractory cells.
SN  - 2073-4409
ER  -