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Peer-reviewedCC BYArchives of gynecology and obstetrics

Surgical quality and long-term outcomes in advanced ovarian cancer: a population based registry study from Hamburg, Germany 2014-2024.

  • Schultz Annemarie1
  • Peters Frederik2
  • Jaeger Anna3
  • Schmalfeldt Barbara4
4 affiliations
  1. 1Hamburg Cancer Registry, Hamburg, Germany. [email protected].
  2. 2Hamburg Cancer Registry, Hamburg, Germany.
  3. 3Department of Gynaecology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
  4. 4Department of Gynaecology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. [email protected].
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Abstract

Purpose

To evaluate the association of surgical quality and survival in patients with advanced ovarian cancer in a real-world setting.Methods

This population-based registry study analysed FIGO stage III/IV ovarian cancer patients in Hamburg, Germany (2014-2024). Patients were categorized by surgical outcome (no macroscopic residuals vs. macroscopic residuals). Kaplan-Meier functions and Cox proportional hazards models estimated associations with survival outcomes.Results

The cohort comprised 576 patients (median age 65 years, median follow-up 57 months). No macroscopic residuals were achieved in 370 patients (64.2%). In multivariable analysis, no macroscopic residuals were associated with reduced mortality risk (HR 0.62, 95% CI: 0.42-0.90) and reduced progression risk (HR 0.68, 95% CI: 0.49-0.94). Advanced FIGO stage, poor performance status, and increasing age were independent predictors of worse outcomes.Conclusion

Achieving no macroscopic residuals remains a critical prognostic factor in advanced ovarian cancer. The rate of 64.2% demonstrates that optimal surgical outcomes are achievable in routine practice, though opportunities for improvement remain compared to specialized centres.

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Cite

BibTeXRIS
BibTeX
@article{annemarie2026surgical,
  title = {{Surgical quality and long-term outcomes in advanced ovarian cancer: a population based registry study from Hamburg, Germany 2014-2024.}},
  author = {Schultz Annemarie and Peters Frederik and Jaeger Anna and Schmalfeldt Barbara},
  journal = {Archives of gynecology and obstetrics},
  year = {2026},
  month = oct,
  doi = {10.1007/s00404-026-08578-x},
  url = {https://europepmc.org/article/MED/42957917},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Surgical quality and long-term outcomes in advanced ovarian cancer: a population based registry study from Hamburg, Germany 2014-2024.
AU  - Schultz Annemarie
AU  - Peters Frederik
AU  - Jaeger Anna
AU  - Schmalfeldt Barbara
PY  - 2026
DA  - 2026/10/29
JO  - Archives of gynecology and obstetrics
DO  - 10.1007/s00404-026-08578-x
UR  - https://europepmc.org/article/MED/42957917
AB  - Purpose  To evaluate the association of surgical quality and survival in patients with advanced ovarian cancer in a real-world setting.Methods  This population-based registry study analysed FIGO stage III/IV ovarian cancer patients in Hamburg, Germany (2014-2024). Patients were categorized by surgical outcome (no macroscopic residuals vs. macroscopic residuals). Kaplan-Meier functions and Cox proportional hazards models estimated associations with survival outcomes.Results  The cohort comprised 576 patients (median age 65 years, median follow-up 57 months). No macroscopic residuals were achieved in 370 patients (64.2%). In multivariable analysis, no macroscopic residuals were associated with reduced mortality risk (HR 0.62, 95% CI: 0.42-0.90) and reduced progression risk (HR 0.68, 95% CI: 0.49-0.94). Advanced FIGO stage, poor performance status, and increasing age were independent predictors of worse outcomes.Conclusion  Achieving no macroscopic residuals remains a critical prognostic factor in advanced ovarian cancer. The rate of 64.2% demonstrates that optimal surgical outcomes are achievable in routine practice, though opportunities for improvement remain compared to specialized centres.
SN  - 0932-0067
SN  - 1432-0711
ER  -