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Peer-reviewedCC BYLeukemia research reports

Intravascular large B-cell lymphoma (IVLBCL) presenting with exclusive cutaneous involvement, no B-symptoms and negative PET-CT: A Case Study.

  • Juliana Gabzdilova1
  • Atila David Homolya2
  • Stefan Raffac3
  • Frantisek Gmitter4
  • Tomas Guman1
  • Viktoria Hazikova5
  • Martina Maria Raffacova6
  • Filip Breznen7
7 affiliations
  1. 1Department of Hematology and Oncohematology, Louis Pasteur University Hospital, Faculty of Medicine, Pavol Jozef Šafárik University, Košice, Slovakia.
  2. 2Department of Radiotherapy and Oncology, East Slovakia Institute of Oncology, Faculty of Medicine, Pavol Jozef Šafárik University, Košice, Slovakia.
  3. 3Department of Clinical Immunology and Allergology, Louis Pasteur University Hospital and OKIA s.r.o, Košice, Slovakia.
  4. 4Department of Pathology, Louis Pasteur University Hospital, Košice, Slovakia.
  5. 5Department of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, Košice, Slovakia.
  6. 6Faculty of Medicine, Pavol Jozef Šafárik University and OKIA s.r.o, Košice, Slovakia.
  7. 7Department of Cardiology, Kardiocentrum AGEL-Šaca a.s., Faculty of Medicine, Pavol Jozef Šafárik University, Košice, Slovakia.
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Abstract

Intravascular large B-cell lymphoma (IVLBCL) is a rare and aggressive subtype of extranodal non-Hodgkin lymphoma (NHL) that typically involves the central nervous system (CNS) and skin in its classic (Western) variant and frequently presents with systemic B-symptoms. We present a rare case of IVLBCL in a 59-year-old female with cutaneous-only involvement, no B-symptoms, and negative PET-CT. The patient's initial presentation mimicked inflammatory conditions, contributing to diagnostic delay. Deep skin biopsy was crucial and confirmed the diagnosis of IVLBCL. PET-CT was non-revealing, showing limitations in cutaneous-dominant disease. The patient underwent R-CHOP treatment along with CNS prophylaxis, achieving complete remission with no relapse at follow-up. This case emphasizes the importance of high suspicion and early biopsy in atypical cutaneous presentations and the need for personalized strategies.

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Cite

BibTeXRIS
BibTeX
@article{gabzdilova2026intravascular,
  title = {{Intravascular large B-cell lymphoma (IVLBCL) presenting with exclusive cutaneous involvement, no B-symptoms and negative PET-CT: A Case Study.}},
  author = {Juliana Gabzdilova and Atila David Homolya and Stefan Raffac and Frantisek Gmitter and Tomas Guman and Viktoria Hazikova and Martina Maria Raffacova and Filip Breznen},
  journal = {Leukemia research reports},
  year = {2026},
  month = oct,
  doi = {10.1016/j.lrr.2026.100619},
  url = {https://europepmc.org/article/MED/42959444},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Intravascular large B-cell lymphoma (IVLBCL) presenting with exclusive cutaneous involvement, no B-symptoms and negative PET-CT: A Case Study.
AU  - Juliana Gabzdilova
AU  - Atila David Homolya
AU  - Stefan Raffac
AU  - Frantisek Gmitter
AU  - Tomas Guman
AU  - Viktoria Hazikova
AU  - Martina Maria Raffacova
AU  - Filip Breznen
PY  - 2026
DA  - 2026/10/17
JO  - Leukemia research reports
DO  - 10.1016/j.lrr.2026.100619
UR  - https://europepmc.org/article/MED/42959444
AB  - Intravascular large B-cell lymphoma (IVLBCL) is a rare and aggressive subtype of extranodal non-Hodgkin lymphoma (NHL) that typically involves the central nervous system (CNS) and skin in its classic (Western) variant and frequently presents with systemic B-symptoms. We present a rare case of IVLBCL in a 59-year-old female with cutaneous-only involvement, no B-symptoms, and negative PET-CT. The patient's initial presentation mimicked inflammatory conditions, contributing to diagnostic delay. Deep skin biopsy was crucial and confirmed the diagnosis of IVLBCL. PET-CT was non-revealing, showing limitations in cutaneous-dominant disease. The patient underwent R-CHOP treatment along with CNS prophylaxis, achieving complete remission with no relapse at follow-up. This case emphasizes the importance of high suspicion and early biopsy in atypical cutaneous presentations and the need for personalized strategies.
SN  - 2213-0489
ER  -