Novel Approach to Scar Reduction: Silicone Gel Enriched With Erbium Borate Nanoparticles
4 affiliations
- 1Department of General Surgery, Istanbul Training and Research Hospital, Health Sciences University, Istanbul, Türkiye
- 2Department of Pathology, Sisli Hamidiye Etfal Health Application and Research Center, Health Sciences University, Istanbul, Türkiye
- 3Department of General Surgery, Faculty of Medicine, Yeditepe University, Istanbul, Türkiye
- 4Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Istanbul, Türkiye
Abstract
Background/Aim: Scar formation following skin injuries from trauma or surgery can result in sensory deficits, loss of flexibility, and significant cosmetic concerns. This study evaluates the potential effects of silicone gel combined with erbium borate nanoparticles on wound healing and scar reduction.
Materials and Methods: Sixteen Wistar albino rats, each with four incisional wounds, were divided into four groups: control, silicone gel with vitamin C, silicone gel with erbium borate nanoparticles, and erbium borate hydrogel. Topical treatments were applied daily for 7 or 21 days, and histopathological evaluations were performed on day 14 and day 28, respectively, including Abramov wound healing scoring and scar elevation index measurements. Hematoxylin-eosin and Masson's trichrome staining were used for the assessments.
Results: Histopathological evaluation on day 14 revealed no significant differences between groups; however, the silicone gel + vitamin C group exhibited more immature collagen fibers (p=0.096). On day 28, collagen deposition was significantly higher in the silicone gel + vitamin C group compared to the silicone gel + erbium borate group (p=0.021), whereas the silicone gel + erbium borate group exhibited more organized and mature collagen fibers. Scar elevation index tended to be lower in the silicone gel+erbium borate group than in the control group.
Conclusion: The combination of silicone gel and erbium borate nanoparticles may improve wound healing and may contribute to improved scar-related outcomes compared with untreated wounds, providing a promising therapeutic approach for improving healing outcomes.
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BibTeX
@article{guler2026novel,
title = {{Novel Approach to Scar Reduction: Silicone Gel Enriched With Erbium Borate Nanoparticles}},
author = {MERT GULER and MERT MAHSUNI SEVINC and RAMAZAN UCAK and HUSNU SEVIK and OMER AKAY and ANIL DEMIR and ERHAN AYSAN and ELCIN YENIGUL and FIKRETTIN SAHIN and UFUK OGUZ IDIZ},
journal = {In Vivo},
year = {2026},
month = oct,
doi = {10.21873/invivo.14496},
url = {https://doi.org/10.21873/invivo.14496},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Novel Approach to Scar Reduction: Silicone Gel Enriched With Erbium Borate Nanoparticles
AU - MERT GULER
AU - MERT MAHSUNI SEVINC
AU - RAMAZAN UCAK
AU - HUSNU SEVIK
AU - OMER AKAY
AU - ANIL DEMIR
AU - ERHAN AYSAN
AU - ELCIN YENIGUL
AU - FIKRETTIN SAHIN
AU - UFUK OGUZ IDIZ
PY - 2026
DA - 2026/10/29
JO - In Vivo
DO - 10.21873/invivo.14496
UR - https://doi.org/10.21873/invivo.14496
AB - Background/Aim: Scar formation following skin injuries from trauma or surgery can result in sensory deficits, loss of flexibility, and significant cosmetic concerns. This study evaluates the potential effects of silicone gel combined with erbium borate nanoparticles on wound healing and scar reduction. Materials and Methods: Sixteen Wistar albino rats, each with four incisional wounds, were divided into four groups: control, silicone gel with vitamin C, silicone gel with erbium borate nanoparticles, and erbium borate hydrogel. Topical treatments were applied daily for 7 or 21 days, and histopathological evaluations were performed on day 14 and day 28, respectively, including Abramov wound healing scoring and scar elevation index measurements. Hematoxylin-eosin and Masson's trichrome staining were used for the assessments. Results: Histopathological evaluation on day 14 revealed no significant differences between groups; however, the silicone gel + vitamin C group exhibited more immature collagen fibers (p=0.096). On day 28, collagen deposition was significantly higher in the silicone gel + vitamin C group compared to the silicone gel + erbium borate group (p=0.021), whereas the silicone gel + erbium borate group exhibited more organized and mature collagen fibers. Scar elevation index tended to be lower in the silicone gel+erbium borate group than in the control group. Conclusion: The combination of silicone gel and erbium borate nanoparticles may improve wound healing and may contribute to improved scar-related outcomes compared with untreated wounds, providing a promising therapeutic approach for improving healing outcomes.
SN - 0258-851X
SN - 1791-7549
ER -