Nano-kinetic implant surface mediates osteo-antibacterial synergy through electromagnetic-mechanical coupling
Abstract
Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty, mainly caused by bacterial biofilm formation and antibiotic resistance. Traditional static surfaces rely on contact killing-based bactericidal properties and cannot reliably clear mature biofilms. In this study, we fabricate a remote-activated dynamic biomimetic system, namely a movable magnetic topographic surface (MMTS). Here we show that under the exposure of external electromagnetic field (EMF), the anchored Janus nano-heterodimers oscillate periodically to mechanically disrupt bacterial membranes and eradicates biofilms of Staphylococcus aureus and Escherichia coli. This mechanical force can also activates Piezo1 mechanosensitive ion channel in bone marrow mesenchymal stem cells (BMSCs), inducing calcium oscillations, upregulating gene expression of Runx2 and BMP2, and enhancing extracellular matrix mineralization. In vivo, MMTS combined with EMF exposure eliminates local infection and promoted osseointegration. This remote-activated dynamic biomimetic strategy offers a promising multifunctional platform for PJI treatment, and improved implant osteointegration in clinical orthopedics.
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BibTeX
@article{chen2026nanokinetic,
title = {{Nano-kinetic implant surface mediates osteo-antibacterial synergy through electromagnetic-mechanical coupling}},
author = {Yangmengfan Chen and Hao Du and Heng Sun and Xingcan Huang and Duan Wang and Xuming Chen and Jiehao Chen and Xuanjun Zhang and Liqiang Zhou and Zongke Zhou},
journal = {Nature Communications},
year = {2026},
month = oct,
doi = {10.1038/s41467-026-78462-4},
url = {https://www.nature.com/articles/s41467-026-78462-4},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Nano-kinetic implant surface mediates osteo-antibacterial synergy through electromagnetic-mechanical coupling
AU - Yangmengfan Chen
AU - Hao Du
AU - Heng Sun
AU - Xingcan Huang
AU - Duan Wang
AU - Xuming Chen
AU - Jiehao Chen
AU - Xuanjun Zhang
AU - Liqiang Zhou
AU - Zongke Zhou
PY - 2026
DA - 2026/10/19
JO - Nature Communications
DO - 10.1038/s41467-026-78462-4
UR - https://www.nature.com/articles/s41467-026-78462-4
AB - Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty, mainly caused by bacterial biofilm formation and antibiotic resistance. Traditional static surfaces rely on contact killing-based bactericidal properties and cannot reliably clear mature biofilms. In this study, we fabricate a remote-activated dynamic biomimetic system, namely a movable magnetic topographic surface (MMTS). Here we show that under the exposure of external electromagnetic field (EMF), the anchored Janus nano-heterodimers oscillate periodically to mechanically disrupt bacterial membranes and eradicates biofilms of Staphylococcus aureus and Escherichia coli. This mechanical force can also activates Piezo1 mechanosensitive ion channel in bone marrow mesenchymal stem cells (BMSCs), inducing calcium oscillations, upregulating gene expression of Runx2 and BMP2, and enhancing extracellular matrix mineralization. In vivo, MMTS combined with EMF exposure eliminates local infection and promoted osseointegration. This remote-activated dynamic biomimetic strategy offers a promising multifunctional platform for PJI treatment, and improved implant osteointegration in clinical orthopedics.
SN - 2041-1723
ER -