Association between the cholesterol-high-density lipoprotein-glucose index and the incidence of new-onset diabetes in patients with chronic gastrointestinal diseases: A prospective cohort study.
- 1Digestive Medicine Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China.
- 2Department of Anesthesiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China.
Abstract
Aims
This study aimed to investigate the association between the cholesterol-high-density lipoprotein-glucose (CHG) index and the incidence of diabetes in patients with chronic gastrointestinal diseases (CGID).Methods
This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS) for the period 2011-2020. The association between the CHG index and new-onset diabetes was assessed using Cox proportional hazards models. Restrictive cubic spline (RCS) analysis was used to examine the dose-response relationship, and time-window analysis assessed the time-dependence of predictive performance. The independent contributions of individual components of the CHG index were investigated using a two-axis decomposition (metabolic burden axis and lipid protection axis).Results
This study enrolled 1,870 CGID patients who were free of diabetes at baseline. During the follow-up period, 289 participants (15.5%) developed new-onset diabetes. CHG index was associated with the risk of new-onset diabetes (HR per 1-SD increase = 1.44, 95% CI: 1.28-1.61). RCS analysis showed no nonlinear relationship (P-nonlinear = 0.773). Time-window analysis showed that the predictive performance of the CHG index increased over time (HR for 0-5 years = 1.33 vs HR for 5-9 years = 1.62, P-interaction <0.001). Two-axis decomposition analysis revealed that the 'high metabolic burden-low lipid protection' group had the highest risk of diabetes (HR = 2.00).Conclusions
The CHG index is an independent risk factor for new-onset diabetes in CGID patients, showing a linear dose-response relationship and time-dependent predictive performance.
Related
- Predictive value of the combined cholesterol, high-density lipoprotein, glucose and frailty indices for cardiometabolic multimorbidity incidence: evidence from a national prospective cohort study
- Small dense low-density lipoprotein cholesterol and risk of cardiovascular events in general adults: a systematic review and meta-analysis of prospective studies.
- Associations of high-density lipoprotein cholesterol concentration and particle count with mortality: a prospective study of 50,000 men and 100,000 women
- Association between the fasting blood glucose to high-density lipoprotein cholesterol ratio and non-alcoholic fatty liver disease in Chinese adults: a secondary analysis
- Association of the triglyceride-to-high-density lipoprotein cholesterol ratio with kidney stone status: cross-sectional and machine-learning analyses
BibTeX
@article{lv2026association,
title = {{Association between the cholesterol-high-density lipoprotein-glucose index and the incidence of new-onset diabetes in patients with chronic gastrointestinal diseases: A prospective cohort study.}},
author = {Liyan Lv and Juhua Wu and Xiaoqing Lin and Shiqian Lan and Yinping Sun},
journal = {Journal of diabetes investigation},
year = {2026},
month = oct,
doi = {10.1111/jdi.70470},
url = {https://europepmc.org/article/MED/42910738},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Association between the cholesterol-high-density lipoprotein-glucose index and the incidence of new-onset diabetes in patients with chronic gastrointestinal diseases: A prospective cohort study.
AU - Liyan Lv
AU - Juhua Wu
AU - Xiaoqing Lin
AU - Shiqian Lan
AU - Yinping Sun
PY - 2026
DA - 2026/10/22
JO - Journal of diabetes investigation
DO - 10.1111/jdi.70470
UR - https://europepmc.org/article/MED/42910738
AB - Aims This study aimed to investigate the association between the cholesterol-high-density lipoprotein-glucose (CHG) index and the incidence of diabetes in patients with chronic gastrointestinal diseases (CGID).Methods This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS) for the period 2011-2020. The association between the CHG index and new-onset diabetes was assessed using Cox proportional hazards models. Restrictive cubic spline (RCS) analysis was used to examine the dose-response relationship, and time-window analysis assessed the time-dependence of predictive performance. The independent contributions of individual components of the CHG index were investigated using a two-axis decomposition (metabolic burden axis and lipid protection axis).Results This study enrolled 1,870 CGID patients who were free of diabetes at baseline. During the follow-up period, 289 participants (15.5%) developed new-onset diabetes. CHG index was associated with the risk of new-onset diabetes (HR per 1-SD increase = 1.44, 95% CI: 1.28-1.61). RCS analysis showed no nonlinear relationship (P-nonlinear = 0.773). Time-window analysis showed that the predictive performance of the CHG index increased over time (HR for 0-5 years = 1.33 vs HR for 5-9 years = 1.62, P-interaction <0.001). Two-axis decomposition analysis revealed that the 'high metabolic burden-low lipid protection' group had the highest risk of diabetes (HR = 2.00).Conclusions The CHG index is an independent risk factor for new-onset diabetes in CGID patients, showing a linear dose-response relationship and time-dependent predictive performance.
SN - 2040-1116
SN - 2040-1124
ER -