Epigenetic signatures of different types of childhood maltreatment in a high-risk sample: a preregistered replication study
Abstract
Childhood maltreatment (CM) has long-lasting effects on physical and mental health with CM type specific effects being reported. Epigenetic processes, like deoxyribonucleic acid methylation (DNAm), might mediate this link, and CM types might be linked to differential alterations in DNAm. While a study by Cecil et al. [1] suggests that different forms of CM share common but also exhibit distinct epigenetic signatures, it is unclear whether these results are generalizable to other high-risk samples. The aim of this preregistered study was to replicate the study of Cecil and colleagues [1] in a sample of N = 116 previously out-of-home placed young adults (32% women, age mean = 26.38, SD = 3.49). Participants completed the Childhood Trauma Questionnaire - Short Form (CTQ-SF), DNA was extracted from whole blood and DNAm was assayed using the Illumina Infinium MethylationEPIC BeadChip Microarray. Using state-of the-art processing pipelines, we failed to replicate the original finding of common and shared epigenetic signatures by CM type. When using a pipeline that was closely matched to the original study, we found that DNAm of cg07032930 was significantly linked to emotional neglect, but in the reverse direction as in the original report. Overall, replication rates per CM subtype were only modest. These findings highlight challenges in independently replicating reported epigenetic associations in high-risk samples and underscore the importance of replication attempts in the field of behavioral epigenetics. Further research is needed to clarify the robustness and specificity of DNAm signatures linked to distinct CM types.
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BibTeX
@article{meier2026epigenetic,
title = {{Epigenetic signatures of different types of childhood maltreatment in a high-risk sample: a preregistered replication study}},
author = {Maria Meier and Laura Gurri and Katharina Beck and Delfine d’Huart and Philippe Jawinski and Cyril Boonmann and Christina Stadler and Marc Schmid and David Bürgin and Eva Unternaehrer},
journal = {Translational Psychiatry},
year = {2026},
month = oct,
doi = {10.1038/s41398-026-04468-7},
url = {https://www.nature.com/articles/s41398-026-04468-7},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Epigenetic signatures of different types of childhood maltreatment in a high-risk sample: a preregistered replication study
AU - Maria Meier
AU - Laura Gurri
AU - Katharina Beck
AU - Delfine d’Huart
AU - Philippe Jawinski
AU - Cyril Boonmann
AU - Christina Stadler
AU - Marc Schmid
AU - David Bürgin
AU - Eva Unternaehrer
PY - 2026
DA - 2026/10/14
JO - Translational Psychiatry
DO - 10.1038/s41398-026-04468-7
UR - https://www.nature.com/articles/s41398-026-04468-7
AB - Childhood maltreatment (CM) has long-lasting effects on physical and mental health with CM type specific effects being reported. Epigenetic processes, like deoxyribonucleic acid methylation (DNAm), might mediate this link, and CM types might be linked to differential alterations in DNAm. While a study by Cecil et al. [1] suggests that different forms of CM share common but also exhibit distinct epigenetic signatures, it is unclear whether these results are generalizable to other high-risk samples. The aim of this preregistered study was to replicate the study of Cecil and colleagues [1] in a sample of N = 116 previously out-of-home placed young adults (32% women, age mean = 26.38, SD = 3.49). Participants completed the Childhood Trauma Questionnaire - Short Form (CTQ-SF), DNA was extracted from whole blood and DNAm was assayed using the Illumina Infinium MethylationEPIC BeadChip Microarray. Using state-of the-art processing pipelines, we failed to replicate the original finding of common and shared epigenetic signatures by CM type. When using a pipeline that was closely matched to the original study, we found that DNAm of cg07032930 was significantly linked to emotional neglect, but in the reverse direction as in the original report. Overall, replication rates per CM subtype were only modest. These findings highlight challenges in independently replicating reported epigenetic associations in high-risk samples and underscore the importance of replication attempts in the field of behavioral epigenetics. Further research is needed to clarify the robustness and specificity of DNAm signatures linked to distinct CM types.
SN - 2158-3188
ER -