Plant-Derived Exosome-like Nanoparticles: Biocompatible Vectors for Efficient Intervention of Autoimmune Diseases
- 1College of Basic Medical Sciences, Shanxi University of Chinese Medicine, Jinzhong 030619, China
Abstract
Autoimmune diseases (AIDs), a group of diseases induced by dysfunction of the immune system, are currently prompting the search for novel intervention strategies. Recent studies have found that plant-derived exosome-like nanoparticles (PELNs) have the potential to restore immune homeostasis. In particular, preclinical evidence indicates that PELNs can modulate the immune microenvironment, inhibit inflammatory pathways, and exert antioxidant and tissue-repair effects. Meanwhile, molecular loading, targeted modification and novel engineering strategies have significantly improved the Intervention precision of PELNs. Based on this, this review summarizes the biological functions, functional advantages, and regulatory mechanisms of PELNs in AIDs and discusses the prospects for their large-scale clinical application in terms of engineering modification, preparation standardization, and multidimensional safety assessment, with the aim of providing a theoretical basis and reference for the development of novel intervention strategies for AIDs.
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BibTeX
@article{zhao2026plantderived,
title = {{Plant-Derived Exosome-like Nanoparticles: Biocompatible Vectors for Efficient Intervention of Autoimmune Diseases}},
author = {Lingyan Zhao and Boyang Hu and Zhenmeng Ren and Ke Li and Yuxin Ma and Lu Wang and Yang Liu},
journal = {International Journal of Molecular Sciences},
year = {2026},
month = nov,
doi = {10.3390/ijms27219866},
url = {https://www.mdpi.com/1422-0067/27/21/9866},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Plant-Derived Exosome-like Nanoparticles: Biocompatible Vectors for Efficient Intervention of Autoimmune Diseases
AU - Lingyan Zhao
AU - Boyang Hu
AU - Zhenmeng Ren
AU - Ke Li
AU - Yuxin Ma
AU - Lu Wang
AU - Yang Liu
PY - 2026
DA - 2026/11/03
JO - International Journal of Molecular Sciences
DO - 10.3390/ijms27219866
UR - https://www.mdpi.com/1422-0067/27/21/9866
AB - Autoimmune diseases (AIDs), a group of diseases induced by dysfunction of the immune system, are currently prompting the search for novel intervention strategies. Recent studies have found that plant-derived exosome-like nanoparticles (PELNs) have the potential to restore immune homeostasis. In particular, preclinical evidence indicates that PELNs can modulate the immune microenvironment, inhibit inflammatory pathways, and exert antioxidant and tissue-repair effects. Meanwhile, molecular loading, targeted modification and novel engineering strategies have significantly improved the Intervention precision of PELNs. Based on this, this review summarizes the biological functions, functional advantages, and regulatory mechanisms of PELNs in AIDs and discusses the prospects for their large-scale clinical application in terms of engineering modification, preparation standardization, and multidimensional safety assessment, with the aim of providing a theoretical basis and reference for the development of novel intervention strategies for AIDs.
SN - 1422-0067
ER -