Association of NT-proBNP with non-alcoholic fatty liver disease in elderly men with normal BMI and incident heart failure
- 1Department of Geriatric Cardiology, the Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital
Abstract
Background: With the increasing burden of lean nonalcoholic fatty liver disease (NAFLD) and heart failure (HF), understanding the relationship between lean NAFLD and NT-proBNP in elderly patients becomes clinically important. This study aimed to identify the risk stratification value of combining NT-proBNP and lean NAFLD in elderly men with incident HF.
Methods: The data from consecutive male patients aged 80 years or older, with incident HF of New York Heart Association class III/IV and a BMI less than 23 kg/m ² , who had available NT-proBNP measurements within 24 h of admission, were retrospectively analyzed. The clinical outcomes were 180-day all-cause and cardiovascular mortality.
Results: A total of 3,627 patients were included. The levels of NT-proBNP were significantly higher in patients without lean NAFLD compared to those with lean NAFLD. After multivariate logistic regression, lean NAFLD remained independently associated with NT-proBNP category. Moreover, during the 180-day follow-up, Kaplan–Meier curves confirmed that patients with both lean NAFLD and NT-proBNP > 8330pg/mL had significantly higher all-cause and cardiovascular mortality compared to those with NT-proBNP alone.
Conclusion: NT-proBNP levels were higher in patients without lean NAFLD than in those with lean NAFLD. The coexistence of lean NAFLD and NT-proBNP > 8330 pg/mL was associated with increased all-cause and cardiovascular mortality in elderly normal-BMI men with incident HF.
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BibTeX
@article{ma2026association,
title = {{Association of NT-proBNP with non-alcoholic fatty liver disease in elderly men with normal BMI and incident heart failure}},
author = {Jinling Ma and Jinxin Wang and Xuan Zhou and Xiaoqian Li},
journal = {Frontiers in Cardiovascular Medicine},
year = {2026},
month = oct,
doi = {10.3389/fcvm.2026.1846048},
url = {https://www.frontiersin.org/articles/10.3389/fcvm.2026.1846048/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Association of NT-proBNP with non-alcoholic fatty liver disease in elderly men with normal BMI and incident heart failure
AU - Jinling Ma
AU - Jinxin Wang
AU - Xuan Zhou
AU - Xiaoqian Li
PY - 2026
DA - 2026/10/13
JO - Frontiers in Cardiovascular Medicine
DO - 10.3389/fcvm.2026.1846048
UR - https://www.frontiersin.org/articles/10.3389/fcvm.2026.1846048/full
AB - Background: With the increasing burden of lean nonalcoholic fatty liver disease (NAFLD) and heart failure (HF), understanding the relationship between lean NAFLD and NT-proBNP in elderly patients becomes clinically important. This study aimed to identify the risk stratification value of combining NT-proBNP and lean NAFLD in elderly men with incident HF. Methods: The data from consecutive male patients aged 80 years or older, with incident HF of New York Heart Association class III/IV and a BMI less than 23 kg/m ² , who had available NT-proBNP measurements within 24 h of admission, were retrospectively analyzed. The clinical outcomes were 180-day all-cause and cardiovascular mortality. Results: A total of 3,627 patients were included. The levels of NT-proBNP were significantly higher in patients without lean NAFLD compared to those with lean NAFLD. After multivariate logistic regression, lean NAFLD remained independently associated with NT-proBNP category. Moreover, during the 180-day follow-up, Kaplan–Meier curves confirmed that patients with both lean NAFLD and NT-proBNP > 8330pg/mL had significantly higher all-cause and cardiovascular mortality compared to those with NT-proBNP alone. Conclusion: NT-proBNP levels were higher in patients without lean NAFLD than in those with lean NAFLD. The coexistence of lean NAFLD and NT-proBNP > 8330 pg/mL was associated with increased all-cause and cardiovascular mortality in elderly normal-BMI men with incident HF.
SN - 2297-055X
ER -