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Peer-reviewedCC BY-NC-NDNpj gut and liver

Bile acid dysmetabolism and microbial dysbiosis coincide with Clostridioides difficile infection in pediatric inflammatory bowel disease.

  • John C Rowe1,2
  • Jenessa A Winston1,2
  1. 1Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, OH USA.
  2. 2Comparative Hepatobiliary Intestinal Research Program (CHIRP), The Ohio State University, Columbus, OH USA.
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Abstract

Pediatric inflammatory bowel disease (IBD) patients are at increased risk for Clostridioides difficile infection. This review highlights bile acid dysmetabolism, driven by gut microbiota dysbiosis and reduced microbial production of secondary bile acids, as a key factor linking pediatric IBD to increased CDI susceptibility. We examine interactions among IBD, dysbiosis, bile acid metabolism, and C. difficile, and discuss emerging microbiome-based interventions aimed at restoring bile acid homeostasis.

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Cite

BibTeXRIS
BibTeX
@article{rowe2026bile,
  title = {{Bile acid dysmetabolism and microbial dysbiosis coincide with Clostridioides difficile infection in pediatric inflammatory bowel disease.}},
  author = {John C Rowe and Jenessa A Winston},
  journal = {Npj gut and liver},
  year = {2026},
  month = nov,
  doi = {10.1038/s44355-026-00084-w},
  url = {https://europepmc.org/article/MED/42996652},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Bile acid dysmetabolism and microbial dysbiosis coincide with Clostridioides difficile infection in pediatric inflammatory bowel disease.
AU  - John C Rowe
AU  - Jenessa A Winston
PY  - 2026
DA  - 2026/11/05
JO  - Npj gut and liver
DO  - 10.1038/s44355-026-00084-w
UR  - https://europepmc.org/article/MED/42996652
AB  - Pediatric inflammatory bowel disease (IBD) patients are at increased risk for Clostridioides difficile infection. This review highlights bile acid dysmetabolism, driven by gut microbiota dysbiosis and reduced microbial production of secondary bile acids, as a key factor linking pediatric IBD to increased CDI susceptibility. We examine interactions among IBD, dysbiosis, bile acid metabolism, and C. difficile, and discuss emerging microbiome-based interventions aimed at restoring bile acid homeostasis.
SN  - 3004-9806
ER  -