Diagnostic accuracy of magnetic resonance imaging for post-radiotherapy recurrent laryngeal cancer: a comparison study with primary laryngeal cancer
- 1Department of Otorhinolaryngology/ Head and Neck Surgery, Faculty of Medicine, Gazi University, Ankara, Türkiye
- 2Department of Radiology, Faculty of Medicine, Gazi University, Ankara, Türkiye
- 3Department of Medical Pathology, Faculty of Medicine, Gazi University, Ankara, Türkiye
Abstract
Objectives: Post-radiotherapy tissue changes in laryngeal cancer can hinder accurate imaging assessment of recurrence and tumour extent. We compared pre-operative magnetic resonance imaging staging performance in recurrent laryngeal cancer versus primary laryngeal cancer.
Methods: Retrospective single-centre study of 51 total laryngectomy patients (2012–2021). Magnetic resonance imaging assessments of invasion/extension were compared with histopathology (reference standard) to compute accuracy, sensitivity and specificity.
Results: Magnetic resonance imaging accuracy differed between groups. In the recurrent laryngeal cancer group, accuracy was highest for lymph node metastasis (88.5 per cent) and extra-laryngeal spread (76.9 per cent), whereas it was lowest for cartilage invasion (53.9 per cent) and paraglottic involvement (57.8 per cent). In the primary laryngeal cancer group, magnetic resonance imaging performed best for subglottic and supraglottic extension (76.0 per cent each) and cartilage invasion (72.0 per cent), but showed limited accuracy for extra-laryngeal spread (36.0 per cent) and lymph node metastasis (60.0 per cent).
Conclusion: Magnetic resonance imaging tended to overestimate tumour extent in both groups. It was sensitive overall, but less specific in certain subsites, particularly the paraglottic region. Negative nodal findings may be reassuring, although conclusions regarding nodal status remain limited.
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BibTeX
@article{cebeci2026diagnostic,
title = {{Diagnostic accuracy of magnetic resonance imaging for post-radiotherapy recurrent laryngeal cancer: a comparison study with primary laryngeal cancer}},
author = {Süleyman Cebeci and Emirhan Akyol and Murat Uçar and Mehmet Arda İnan and M.Mehmet İncesu and Ilayda Kılıç and Mehmet Düzlü and Utku Aydil and Muammer Melih Şahin and Recep Karamert},
journal = {The Journal of Laryngology and Otology},
year = {2026},
month = oct,
doi = {10.1017/s0022215126105052},
url = {https://doi.org/10.1017/s0022215126105052},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Diagnostic accuracy of magnetic resonance imaging for post-radiotherapy recurrent laryngeal cancer: a comparison study with primary laryngeal cancer
AU - Süleyman Cebeci
AU - Emirhan Akyol
AU - Murat Uçar
AU - Mehmet Arda İnan
AU - M.Mehmet İncesu
AU - Ilayda Kılıç
AU - Mehmet Düzlü
AU - Utku Aydil
AU - Muammer Melih Şahin
AU - Recep Karamert
PY - 2026
DA - 2026/10/30
JO - The Journal of Laryngology and Otology
DO - 10.1017/s0022215126105052
UR - https://doi.org/10.1017/s0022215126105052
AB - Objectives: Post-radiotherapy tissue changes in laryngeal cancer can hinder accurate imaging assessment of recurrence and tumour extent. We compared pre-operative magnetic resonance imaging staging performance in recurrent laryngeal cancer versus primary laryngeal cancer. Methods: Retrospective single-centre study of 51 total laryngectomy patients (2012–2021). Magnetic resonance imaging assessments of invasion/extension were compared with histopathology (reference standard) to compute accuracy, sensitivity and specificity. Results: Magnetic resonance imaging accuracy differed between groups. In the recurrent laryngeal cancer group, accuracy was highest for lymph node metastasis (88.5 per cent) and extra-laryngeal spread (76.9 per cent), whereas it was lowest for cartilage invasion (53.9 per cent) and paraglottic involvement (57.8 per cent). In the primary laryngeal cancer group, magnetic resonance imaging performed best for subglottic and supraglottic extension (76.0 per cent each) and cartilage invasion (72.0 per cent), but showed limited accuracy for extra-laryngeal spread (36.0 per cent) and lymph node metastasis (60.0 per cent). Conclusion: Magnetic resonance imaging tended to overestimate tumour extent in both groups. It was sensitive overall, but less specific in certain subsites, particularly the paraglottic region. Negative nodal findings may be reassuring, although conclusions regarding nodal status remain limited.
SN - 0022-2151
SN - 1748-5460
ER -