From Candidate Hierarchy to Experimental Dependency Map: Post-HTP1.6 Updated Edition.
- 1Independent Researcher
Abstract
Post-HTP1.6 updated edition of the Theory of Everything Research Programme synthesis paper. The previously published Post-TP1 edition is preserved and followed by an addendum incorporating the prospective HTP1.6 matched-control adjudication. The original TP1-A result remains supported: causal self-maintenance emerged in all 40 preregistered artificial CRN populations. HTP1.6 then tested whether that external disturbance-recovery phenotype uniquely required the evolved catalytic architecture. Of 40 new targets, 21 obtained adequately matched non-catalytic expanded-passive controls and all 21 reproduced the held-out functional profile (bypass proportion 1.000; Wilson 95% CI approximately 0.845-1.000). The dependency map is therefore refined into TP1-A1 (causal self-maintenance emergence: SUPPORTED), TP1-A2 (catalytic architectural uniqueness/necessity: NOT SUPPORTED), and TP1-P (physical/protocellular transport: OPEN). TP2, TP3, TP4 and OP1 retain their previous statuses.
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BibTeX
@misc{craggs2026from,
title = {{From Candidate Hierarchy to Experimental Dependency Map: Post-HTP1.6 Updated Edition.}},
author = {Kenneth Craggs},
howpublished = {Zenodo},
year = {2026},
month = oct,
doi = {10.5281/zenodo.23644651},
url = {https://zenodo.org/records/23644651},
note = {CC BY 4.0},
}
RIS
TY - UNPB
TI - From Candidate Hierarchy to Experimental Dependency Map: Post-HTP1.6 Updated Edition.
AU - Kenneth Craggs
PY - 2026
DA - 2026/10/25
PB - Zenodo
DO - 10.5281/zenodo.23644651
UR - https://zenodo.org/records/23644651
AB - Post-HTP1.6 updated edition of the Theory of Everything Research Programme synthesis paper. The previously published Post-TP1 edition is preserved and followed by an addendum incorporating the prospective HTP1.6 matched-control adjudication. The original TP1-A result remains supported: causal self-maintenance emerged in all 40 preregistered artificial CRN populations. HTP1.6 then tested whether that external disturbance-recovery phenotype uniquely required the evolved catalytic architecture. Of 40 new targets, 21 obtained adequately matched non-catalytic expanded-passive controls and all 21 reproduced the held-out functional profile (bypass proportion 1.000; Wilson 95% CI approximately 0.845-1.000). The dependency map is therefore refined into TP1-A1 (causal self-maintenance emergence: SUPPORTED), TP1-A2 (catalytic architectural uniqueness/necessity: NOT SUPPORTED), and TP1-P (physical/protocellular transport: OPEN). TP2, TP3, TP4 and OP1 retain their previous statuses.
ER -