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Peer-reviewedCC BY-NC-NDThe Plant Cell

Tyrosine-sulfated peptide-induced flavonol biosynthesis controls elongation and differentiation in Arabidopsis primary root

  • María Florencia Ercoli1,2,3
  • Alexandra M. Shigenaga1,2
  • Artur Teixeira de Araújo1,4,2
  • Katherine Louie5
  • Benjamin P. Bowen6,5
  • Tracy Satomi Weitz1,2
  • Sangeetha Ramesh1,2
  • Rashmi Jain1,2
  • Trent R. Northen6,5
  • Pamela C. Ronald1,4,2,3
6 affiliations
  1. 1Department of Plant Pathology, University of California , Davis, CA 95616, United States
  2. 2The Genome Center, University of California , Davis, CA 95616, United States
  3. 3The Innovative Genomics Institute, University of California , Berkeley, CA 94720 , United States
  4. 4Joint BioEnergy Institute DOE , Emeryville, CA 94608 , United States
  5. 5Joint Genome Institute, Lawrence Berkeley National Laboratory , Berkeley, CA 94720, United States
  6. 6Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory , Berkeley, CA 94720 , United States
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Abstract

In Arabidopsis (Arabidopsis thaliana) roots, growth initiation and cessation are organized into distinct zones. How regulatory mechanisms are integrated to coordinate these processes and maintain proper growth progression over time remains poorly understood. Here, we demonstrate that the peptide hormone PLANT PEPTIDE CONTAINING SULFATED TYROSINE 1 (PSY1) promotes root growth by controlling cell elongation. Higher levels of PSY1 lead to longer differentiated cells with a shootward displacement of characteristics common to mature cells. PSY1 activates genes involved in the biosynthesis of flavonols, a group of plant-specific specialized metabolites. Consistent with these transcriptional changes, metabolomic analysis reveals an enrichment of diverse flavonol glycosides upon PSY1 treatment. Using genetic and chemical approaches, we show that PSY1-mediated flavonol accumulation is localized to the differentiation zone and is required for PSY1 function. PSY1 signaling in this zone is associated with a reduction of hydrogen peroxide accumulation and a decrease in auxin-induced gene expression. These findings support a model where PSY1 signals the developmental-specific accumulation of specialized metabolites to regulate the extent of cell elongation and progression to maturation.

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Cite

BibTeXRIS
BibTeX
@article{ercoli2026tyrosinesulfated,
  title = {{Tyrosine-sulfated peptide-induced flavonol biosynthesis controls elongation and differentiation in Arabidopsis primary root}},
  author = {María Florencia Ercoli and Alexandra M. Shigenaga and Artur Teixeira de Araújo and Katherine Louie and Benjamin P. Bowen and Tracy Satomi Weitz and Sangeetha Ramesh and Rashmi Jain and Trent R. Northen and Pamela C. Ronald},
  journal = {The Plant Cell},
  year = {2026},
  month = jun,
  doi = {10.1093/plcell/koag180},
  url = {https://doi.org/10.1093/plcell/koag180},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Tyrosine-sulfated peptide-induced flavonol biosynthesis controls elongation and differentiation in Arabidopsis primary root
AU  - María Florencia Ercoli
AU  - Alexandra M. Shigenaga
AU  - Artur Teixeira de Araújo
AU  - Katherine Louie
AU  - Benjamin P. Bowen
AU  - Tracy Satomi Weitz
AU  - Sangeetha Ramesh
AU  - Rashmi Jain
AU  - Trent R. Northen
AU  - Pamela C. Ronald
PY  - 2026
DA  - 2026/06/16
JO  - The Plant Cell
DO  - 10.1093/plcell/koag180
UR  - https://doi.org/10.1093/plcell/koag180
AB  - In Arabidopsis (Arabidopsis thaliana) roots, growth initiation and cessation are organized into distinct zones. How regulatory mechanisms are integrated to coordinate these processes and maintain proper growth progression over time remains poorly understood. Here, we demonstrate that the peptide hormone PLANT PEPTIDE CONTAINING SULFATED TYROSINE 1 (PSY1) promotes root growth by controlling cell elongation. Higher levels of PSY1 lead to longer differentiated cells with a shootward displacement of characteristics common to mature cells. PSY1 activates genes involved in the biosynthesis of flavonols, a group of plant-specific specialized metabolites. Consistent with these transcriptional changes, metabolomic analysis reveals an enrichment of diverse flavonol glycosides upon PSY1 treatment. Using genetic and chemical approaches, we show that PSY1-mediated flavonol accumulation is localized to the differentiation zone and is required for PSY1 function. PSY1 signaling in this zone is associated with a reduction of hydrogen peroxide accumulation and a decrease in auxin-induced gene expression. These findings support a model where PSY1 signals the developmental-specific accumulation of specialized metabolites to regulate the extent of cell elongation and progression to maturation.
SN  - 1040-4651
SN  - 1532-298X
ER  -