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Peer-reviewedCC BY-NC-NDThe Journal of comparative neurology

Age-Related Changes in Density, Arborization, and NMDA Receptor Expression in Somatostatin Interneurons of the Mouse mPFC.

  • Blanca Sánchez-Moreno1,2
  • Yaiza Gramuntell3,4,5
  • Patrycja Klimczak3,4,5
  • Evelina Bäcker1,2
  • Juan Nácher3,4,5
  • Javier Gilabert-Juan1,2
5 affiliations
  1. 1Department of Anatomy, Histology and Neuroscience, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
  2. 2PhD Program in Neuroscience Cajal-UAM, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
  3. 3Institute of Biotechnology and Biomedicine (BIOTECMED), Universitat de València, Burjassot, Spain.
  4. 4CIBERSAM, ISCIII Spanish National Network for Research in Mental Health, Madrid, Spain.
  5. 5Biomedical Research Institute of the Clinic Hospital of Valencia (INCLIVA), Valencia, Spain.
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Abstract

Aging is associated with progressive alterations in cortical circuits that compromise cognitive function. Somatostatin-positive (SST+) Martinotti interneurons, which regulate pyramidal cell activity in the medial prefrontal cortex (mPFC), are particularly relevant for inhibitory control, yet their age-related vulnerability remains poorly understood. Here, we examined GFP-labeled SST+ interneurons in mice at 3, 9, and 16 months of age, focusing on neuronal density, dendritic arborization, and expression of NMDA receptor subunits GluN1 and GluN2B. Our findings reveal a significant decline in SST+ interneuron density in aged male mice, whereas female mice displayed an increase in dendritic arborization with age. Analysis of NMDA receptor puncta showed a reduction in GluN1 and GluN2B density with increased puncta size in older animals. Together, these findings reveal age- and sex-dependent structural and molecular remodeling of SST+ interneurons in the mPFC.

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Cite

BibTeXRIS
BibTeX
@article{sanchezmoreno2026agerelated,
  title = {{Age-Related Changes in Density, Arborization, and NMDA Receptor Expression in Somatostatin Interneurons of the Mouse mPFC.}},
  author = {Blanca Sánchez-Moreno and Yaiza Gramuntell and Patrycja Klimczak and Evelina Bäcker and Juan Nácher and Javier Gilabert-Juan},
  journal = {The Journal of comparative neurology},
  year = {2026},
  month = oct,
  doi = {10.1002/cne.70217},
  url = {https://europepmc.org/article/MED/42876423},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Age-Related Changes in Density, Arborization, and NMDA Receptor Expression in Somatostatin Interneurons of the Mouse mPFC.
AU  - Blanca Sánchez-Moreno
AU  - Yaiza Gramuntell
AU  - Patrycja Klimczak
AU  - Evelina Bäcker
AU  - Juan Nácher
AU  - Javier Gilabert-Juan
PY  - 2026
DA  - 2026/10/01
JO  - The Journal of comparative neurology
DO  - 10.1002/cne.70217
UR  - https://europepmc.org/article/MED/42876423
AB  - Aging is associated with progressive alterations in cortical circuits that compromise cognitive function. Somatostatin-positive (SST+) Martinotti interneurons, which regulate pyramidal cell activity in the medial prefrontal cortex (mPFC), are particularly relevant for inhibitory control, yet their age-related vulnerability remains poorly understood. Here, we examined GFP-labeled SST+ interneurons in mice at 3, 9, and 16 months of age, focusing on neuronal density, dendritic arborization, and expression of NMDA receptor subunits GluN1 and GluN2B. Our findings reveal a significant decline in SST+ interneuron density in aged male mice, whereas female mice displayed an increase in dendritic arborization with age. Analysis of NMDA receptor puncta showed a reduction in GluN1 and GluN2B density with increased puncta size in older animals. Together, these findings reveal age- and sex-dependent structural and molecular remodeling of SST+ interneurons in the mPFC.
SN  - 0021-9967
SN  - 1096-9861
ER  -