Site Versus Core Lab-Adjudicated First- and Final-Pass eTICI Scores Compared During Off and Normal Hours: Insights From the ASSIST Registry
14 affiliations
- 1Aurora Neurosciences Innovation Institute, Advocate Aurora Health, Milwaukee, WI (S.D.).
- 2Hospital Son Espases, Mallorca, Spain (S.M.).
- 3McLaren Regional Medical Center, Macomb, MI (B.N.).
- 4Medical University of South Carolina, Charleston (A.S.).
- 5Klinikum Vest Recklinghausen, Recklinghausen, Germany (C.L.).
- 6Hospital Clínico Universitario de Valladolid, Spain (M.M.-G.).
- 7Rhode Island Hospital, Providence (R.M.).
- 8Ghent University Hospital, Belgium (L.D.).
- 9Hospital Universitario Central de Asturias-HUCA, Oviedo, Spain (P.V.).
- 10Neuroscience Department, Bon Secours Mercy Health St. Vincent Medical Center, Toledo, OH (O.O.Z.).
- 11Stryker Neurovascular, Fremont, CA (L.L.P.).
- 12Department of Neurology and Comprehensive Stroke Center, David Geffen School of Medicine, University of California, Los Angeles (D.S.L.).
- 13Uniklinik Heidelberg, Germany (M.M.).
- 14Department of Neurology, WellStar Health System, Marietta, GA (R.G.).
Abstract
Background
Data from the ASSIST registry were analyzed to assess whether site-reported expanded Treatment in Cerebral Infarction (eTICI) scores differ from those reported by the core lab during off hours compared with normal hours. We also assessed whether outcomes are worse in procedures performed during off hours.Methods
Details from the registry have been previously published. Regression models were performed for first-pass treatment of target occlusion resulting in ≥2c by the core lab, agreement for final pass ≥2c, modified Rankin Scale 0 to 2 at 90 days, and whether first-pass eTICI ≥2c agreed between the core lab and site-reported assessments.Results
A total of 1318 patients were included. Overall, agreement between core-lab and site-reported eTICI for first-pass eTICI ≥2c occurred in 86.7% and 78.5% for final eTICI ≥2c. Agreement for first-pass and final-pass eTICI ≥2c occurred in 87.2% and 77.7% during normal hours and 86.1% and 79.3% during off hours. Good functional outcomes occurred in 55.5% of patients presenting during normal hours and 53.8% of patients presenting during off hours. Off-hour versus normal-hour procedures were not significantly associated with first-pass efficacy, modified Rankin Scale 0 to 2 at 90 days, or whether first-pass eTICI agreed between the core lab and site-reported assessments in adjusted regression analyses.Conclusions
There was a higher level of agreement between core-lab and site-reported first-pass eTICI scores during all hours, while agreement occurred less often for final reperfusion. These results suggest a high level of correlation regardless of the time of the procedure between site-adjudicated and core-lab-adjudicated successful reperfusion grading. There were no significant differences in outcomes irrespective of the timing of thrombectomy.Registration
URL: https://www.clinicaltrials.gov; Unique identifier: NCT03845491.
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BibTeX
@article{dandapat2026site,
title = {{Site Versus Core Lab-Adjudicated First- and Final-Pass eTICI Scores Compared During Off and Normal Hours: Insights From the ASSIST Registry}},
author = {Sudeepta Dandapat and Salvador Miralbés and Bharath Naravetla and Alejandro Spiotta and Christian Loehr and Mario Martínez-Galdámez and Ryan McTaggart and Luc Defreyne and Pedro Vega and Osama O Zaidat and Lori Lyn Price and David S Liebeskind and Markus Möhlenbruch and Rishi Gupta},
journal = {Stroke (Hoboken, N.J.)},
year = {2026},
month = oct,
doi = {10.1161/svin.126.002502},
url = {https://europepmc.org/article/PMC/PMC13727278},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Site Versus Core Lab-Adjudicated First- and Final-Pass eTICI Scores Compared During Off and Normal Hours: Insights From the ASSIST Registry
AU - Sudeepta Dandapat
AU - Salvador Miralbés
AU - Bharath Naravetla
AU - Alejandro Spiotta
AU - Christian Loehr
AU - Mario Martínez-Galdámez
AU - Ryan McTaggart
AU - Luc Defreyne
AU - Pedro Vega
AU - Osama O Zaidat
AU - Lori Lyn Price
AU - David S Liebeskind
AU - Markus Möhlenbruch
AU - Rishi Gupta
PY - 2026
DA - 2026/10/07
JO - Stroke (Hoboken, N.J.)
DO - 10.1161/svin.126.002502
UR - https://europepmc.org/article/PMC/PMC13727278
AB - Background Data from the ASSIST registry were analyzed to assess whether site-reported expanded Treatment in Cerebral Infarction (eTICI) scores differ from those reported by the core lab during off hours compared with normal hours. We also assessed whether outcomes are worse in procedures performed during off hours.Methods Details from the registry have been previously published. Regression models were performed for first-pass treatment of target occlusion resulting in ≥2c by the core lab, agreement for final pass ≥2c, modified Rankin Scale 0 to 2 at 90 days, and whether first-pass eTICI ≥2c agreed between the core lab and site-reported assessments.Results A total of 1318 patients were included. Overall, agreement between core-lab and site-reported eTICI for first-pass eTICI ≥2c occurred in 86.7% and 78.5% for final eTICI ≥2c. Agreement for first-pass and final-pass eTICI ≥2c occurred in 87.2% and 77.7% during normal hours and 86.1% and 79.3% during off hours. Good functional outcomes occurred in 55.5% of patients presenting during normal hours and 53.8% of patients presenting during off hours. Off-hour versus normal-hour procedures were not significantly associated with first-pass efficacy, modified Rankin Scale 0 to 2 at 90 days, or whether first-pass eTICI agreed between the core lab and site-reported assessments in adjusted regression analyses.Conclusions There was a higher level of agreement between core-lab and site-reported first-pass eTICI scores during all hours, while agreement occurred less often for final reperfusion. These results suggest a high level of correlation regardless of the time of the procedure between site-adjudicated and core-lab-adjudicated successful reperfusion grading. There were no significant differences in outcomes irrespective of the timing of thrombectomy.Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT03845491.
SN - 2694-5746
ER -