A pan-eukaryotic analysis of mitochondrial ribosomes uncovers major evolutionary transitions
- 1Charles University
Abstract
Mitochondrial ribosomes (mitoribosomes) have diverged extensively both from their bacterial ancestors and across eukaryotes, and while many general trends have been identified, fundamental features of their evolution remain unclear. We analyzed sequences from 85 eukaryotes to chart protein composition across the evolution of mitochondrial translation. We both reconstruct the LECA mitoribosomal proteome as containing nearly the full bacterial protein complement and at least 23 proteins recruited after -proteobacterial endosymbiosis and describe the subsequent extensive but lineage-specific remodeling post LECA. We further uncover previously unrecognized homologies among several mitoribosomal proteins and unify and update the mitoribosomal nomenclature. Our data also support protein retargeting between organellar ribosomes, documenting remarkable intercompartmental structural compatibility. Together, these findings highlight the exceptional evolutionary plasticity of mitoribosomes and provide a comprehensive reference framework for future analysis.
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BibTeX
@misc{panek2026paneukaryotic,
title = {{A pan-eukaryotic analysis of mitochondrial ribosomes uncovers major evolutionary transitions}},
author = {T. Panek and J. Riha and P. Corre and E. Zadrobilkova and H. Vummadi and A. Suri and P. Chauhan and J. E. Wong and K. Senk and A. S. Petrov and V. Tobiasson and O. Gahura},
howpublished = {bioRxiv},
year = {2026},
month = oct,
doi = {10.64898/2026.10.06.756942},
url = {https://www.biorxiv.org/content/10.64898/2026.10.06.756942v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - A pan-eukaryotic analysis of mitochondrial ribosomes uncovers major evolutionary transitions
AU - T. Panek
AU - J. Riha
AU - P. Corre
AU - E. Zadrobilkova
AU - H. Vummadi
AU - A. Suri
AU - P. Chauhan
AU - J. E. Wong
AU - K. Senk
AU - A. S. Petrov
AU - V. Tobiasson
AU - O. Gahura
PY - 2026
DA - 2026/10/06
PB - bioRxiv
DO - 10.64898/2026.10.06.756942
UR - https://www.biorxiv.org/content/10.64898/2026.10.06.756942v1
AB - Mitochondrial ribosomes (mitoribosomes) have diverged extensively both from their bacterial ancestors and across eukaryotes, and while many general trends have been identified, fundamental features of their evolution remain unclear. We analyzed sequences from 85 eukaryotes to chart protein composition across the evolution of mitochondrial translation. We both reconstruct the LECA mitoribosomal proteome as containing nearly the full bacterial protein complement and at least 23 proteins recruited after -proteobacterial endosymbiosis and describe the subsequent extensive but lineage-specific remodeling post LECA. We further uncover previously unrecognized homologies among several mitoribosomal proteins and unify and update the mitoribosomal nomenclature. Our data also support protein retargeting between organellar ribosomes, documenting remarkable intercompartmental structural compatibility. Together, these findings highlight the exceptional evolutionary plasticity of mitoribosomes and provide a comprehensive reference framework for future analysis.
ER -