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Peer-reviewedCC BY-NCCancer medicine

Increased Healthcare Utilization and Differential Outcomes for Pediatric Cancer Versus Non-Cancer Patients.

  • Yujie Chen1
  • Martin Yi1
  • Catherine C Aftandilian2
  • Melissa P Beauchemin3
  • Christine Cunningham2
  • Emily Larimer4
  • Jennifer Oberg5
  • Benjamin L May5
  • Keith Morse2,6
  • Karthik Natarajan7
  • David Noyd4
  • Vicki Soucek4
4 more authors
  • Rhea K Khurana5
  • Phil Sim4
  • Lin Lawrence Guo1
  • Lillian Sung1,8
8 affiliations
  1. 1Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada.
  2. 2Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California, USA.
  3. 3Columbia University School of Nursing/Herbert Irving Cancer Center, New York, New York, USA.
  4. 4Ben Towne Center for Childhood Cancer and Blood Disorders Research and the Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, Washington, USA.
  5. 5Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.
  6. 6Stanford Center for Biomedical Informatics Research, Stanford University, Palo Alto, California, USA.
  7. 7Data Sciences Unit, Columbia University, New York, New York, USA.
  8. 8Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
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Abstract

Background

The Observational Medical Outcomes Partnership Common Data Model (OMOP CDM) is a data standard that enables multicenter research. Primary objective was to describe the magnitude of healthcare utilization in pediatric cancer versus non-cancer patients. Secondary objective was to compare 6-month clinical outcomes related to abnormal lab tests and mortality.Methods

In this multicenter retrospective study, we included pediatric patients 0-18 years at first medication administration. Cancer patients had a malignant neoplastic disease diagnosis and received chemotherapy. Index date was the first chemotherapy date. Non-cancer patients were assigned analogous index dates based on randomly sampled first medication to chemotherapy intervals. Outcomes were measured within 6 months of index date. Healthcare utilization included encounters, procedures, radiology, lab tests, and medications.Results

Among 2810 cancer and 11,240 non-cancer patients, all evaluated healthcare utilization measures were significantly more common in cancer patients. The largest relative differences were observed for long inpatient stay (risk ratio [RR] 26.32, 95% confidence interval [CI] 15.00-46.17), computed tomography (RR 23.59, 95% CI 19.24-28.92), blood culture (RR 37.04, 95% CI 9.58-143.14), and intravenous medication (RR 17.69, 95% CI 8.75-35.75). Death within 6 months was higher for cancer versus non-cancer patients (RR 38.37, 95% CI 12.91-114.04).Conclusions

Using the OMOP CDM, we found greater healthcare utilization and worse clinical outcomes among pediatric cancer patients than non-cancer patients, with the largest relative differences observed for inpatient stay, computed tomography, blood culture, and intravenous medication. These findings provide insight into resource utilization patterns and illustrate the OMOP CDM research potential for multicenter studies.

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Cite

BibTeXRIS
BibTeX
@article{chen2026increased,
  title = {{Increased Healthcare Utilization and Differential Outcomes for Pediatric Cancer Versus Non-Cancer Patients.}},
  author = {Yujie Chen and Martin Yi and Catherine C Aftandilian and Melissa P Beauchemin and Christine Cunningham and Emily Larimer and Jennifer Oberg and Benjamin L May and Keith Morse and Karthik Natarajan and David Noyd and Vicki Soucek and Rhea K Khurana and Phil Sim and Lin Lawrence Guo and Lillian Sung},
  journal = {Cancer medicine},
  year = {2026},
  month = oct,
  doi = {10.1002/cam4.72459},
  url = {https://europepmc.org/article/MED/42958816},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Increased Healthcare Utilization and Differential Outcomes for Pediatric Cancer Versus Non-Cancer Patients.
AU  - Yujie Chen
AU  - Martin Yi
AU  - Catherine C Aftandilian
AU  - Melissa P Beauchemin
AU  - Christine Cunningham
AU  - Emily Larimer
AU  - Jennifer Oberg
AU  - Benjamin L May
AU  - Keith Morse
AU  - Karthik Natarajan
AU  - David Noyd
AU  - Vicki Soucek
AU  - Rhea K Khurana
AU  - Phil Sim
AU  - Lin Lawrence Guo
AU  - Lillian Sung
PY  - 2026
DA  - 2026/10/29
JO  - Cancer medicine
DO  - 10.1002/cam4.72459
UR  - https://europepmc.org/article/MED/42958816
AB  - Background  The Observational Medical Outcomes Partnership Common Data Model (OMOP CDM) is a data standard that enables multicenter research. Primary objective was to describe the magnitude of healthcare utilization in pediatric cancer versus non-cancer patients. Secondary objective was to compare 6-month clinical outcomes related to abnormal lab tests and mortality.Methods  In this multicenter retrospective study, we included pediatric patients 0-18 years at first medication administration. Cancer patients had a malignant neoplastic disease diagnosis and received chemotherapy. Index date was the first chemotherapy date. Non-cancer patients were assigned analogous index dates based on randomly sampled first medication to chemotherapy intervals. Outcomes were measured within 6 months of index date. Healthcare utilization included encounters, procedures, radiology, lab tests, and medications.Results  Among 2810 cancer and 11,240 non-cancer patients, all evaluated healthcare utilization measures were significantly more common in cancer patients. The largest relative differences were observed for long inpatient stay (risk ratio [RR] 26.32, 95% confidence interval [CI] 15.00-46.17), computed tomography (RR 23.59, 95% CI 19.24-28.92), blood culture (RR 37.04, 95% CI 9.58-143.14), and intravenous medication (RR 17.69, 95% CI 8.75-35.75). Death within 6 months was higher for cancer versus non-cancer patients (RR 38.37, 95% CI 12.91-114.04).Conclusions  Using the OMOP CDM, we found greater healthcare utilization and worse clinical outcomes among pediatric cancer patients than non-cancer patients, with the largest relative differences observed for inpatient stay, computed tomography, blood culture, and intravenous medication. These findings provide insight into resource utilization patterns and illustrate the OMOP CDM research potential for multicenter studies.
SN  - 2045-7634
ER  -