Well‐Defined Anilido–Imine Iron(II) Complexes for Catalytic Intramolecular Alkene Hydroamination of Primary Amines
Abstract
Despite the appeal of the scientific community for alkene hydroamination methodology to straightforwardly access valuable N ‐containing compounds from ubiquitous amines and alkenes, there is still a need to develop sustainable catalysts for the direct addition of simple and free amines with high atom efficiency. We herein report the synthesis and characterization of an array of structurally defined three‐coordinate anilido–imine Fe(II) alkyl complexes that show high catalytic activity and selectivity in the intramolecular hydroamination of unprotected primary amines tethered to unactivated alkenes. The influences of steric and electronic ligand variations on the catalytic efficiency of the process were examined. They led to the development of an anilido–imine Fe(II) catalyst far more active than previously reported β ‐diketiminate Fe(II) catalysts, exhibiting even catalytic activity at room temperature and displaying broader scope.
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BibTeX
@article{dong2026welldefined,
title = {{Well‐Defined Anilido–Imine Iron(II) Complexes for Catalytic Intramolecular Alkene Hydroamination of Primary Amines}},
author = {Hui Dong and Clément Lepori and Régis Guillot and Richard Gil and Sophie Bezzenine and Jérôme Hannedouche},
journal = {European Journal of Organic Chemistry},
year = {2026},
month = jun,
doi = {10.1002/ejoc.70559},
url = {https://hal.science/hal-05771688v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - Well‐Defined Anilido–Imine Iron(II) Complexes for Catalytic Intramolecular Alkene Hydroamination of Primary Amines
AU - Hui Dong
AU - Clément Lepori
AU - Régis Guillot
AU - Richard Gil
AU - Sophie Bezzenine
AU - Jérôme Hannedouche
PY - 2026
DA - 2026/06/11
JO - European Journal of Organic Chemistry
DO - 10.1002/ejoc.70559
UR - https://hal.science/hal-05771688v1
AB - Despite the appeal of the scientific community for alkene hydroamination methodology to straightforwardly access valuable N ‐containing compounds from ubiquitous amines and alkenes, there is still a need to develop sustainable catalysts for the direct addition of simple and free amines with high atom efficiency. We herein report the synthesis and characterization of an array of structurally defined three‐coordinate anilido–imine Fe(II) alkyl complexes that show high catalytic activity and selectivity in the intramolecular hydroamination of unprotected primary amines tethered to unactivated alkenes. The influences of steric and electronic ligand variations on the catalytic efficiency of the process were examined. They led to the development of an anilido–imine Fe(II) catalyst far more active than previously reported β ‐diketiminate Fe(II) catalysts, exhibiting even catalytic activity at room temperature and displaying broader scope.
SN - 1434-193X
SN - 1099-0690
ER -