Retrospective clinical artificial intelligence-assisted study of loaded peri-implant versus edentulous bone
7 affiliations
- 1Department of Neuroscience, Imaging and Clinical Sciences, University G. d’Annunzio of Chieti-Pescara
- 2Department of Medical, Oral and Biotechnological Sciences, University “G. d’Annunzio”
- 3Department of Surgical, Medical, Molecular Pathologies and of the Critical Area, University of Pisa
- 4Department of Biomedical Sciences and Public Health, Marche Polytechnic University
- 5Elettra-Sincrotrone Trieste S.C.p.A
- 6Lum “Giuseppe Degennaro” University
- 7Department of Clinical Specialistic and Dental Sciences, Marche Polytechnic University
Abstract
This study aims to clarify the relationship between mechanical stimulation by masticatory loading, bone mineralization distribution (BMD) and osteocyte lacunar shape complexity features (SCFs), through the retrospective clinical analysis of peri-implant bone compared to edentulous bone in human jaws. The multivariate analysis was conducted in two dental contexts: in peri-implant bone, subjected to mechanical forces during chewing, and in edentulous bone, not subjected to masticatory load. The study was conducted by synchrotron radiation high-resolution phase-contrast tomography combined with artificial intelligence (AI)-based image segmentation techniques. Histomorphometry was performed to verify and complement results with additional information on soft tissues. Osteocyte lacunar volume was shown to be significantly larger in the peri-implant group than in the edentulous group. Wide distributions of Aspect Ratio and Sphericity were found in edentulous specimens; this variation was not observed among peri-implant bone samples, suggesting that loading affects peri-implant lacunar SCFs, making them more uniform in shape and size. Lacunar SCFs were found highly correlated with BMD parameters only in the peri-implant (loaded) tissues and not in the edentulous bone. Overall, our results confirm that mechanical loading positively influences osteocyte activity, which suggests that immediate loading of dental implants has a biologic rationale.
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BibTeX
@article{riberti2026retrospective,
title = {{Retrospective clinical artificial intelligence-assisted study of loaded peri-implant versus edentulous bone}},
author = {Nicole Riberti and Emira D’Amico and Chiara Cinquini and Michele Furlani and Tania Vanessa Pierfelice and Giovanna Iezzi and Elena Longo and Michele Covelli and Antonio Barone and Alessandra Giuliani},
journal = {Scientific Reports},
year = {2026},
month = jul,
doi = {10.1038/s41598-026-64441-8},
url = {https://doi.org/10.1038/s41598-026-64441-8},
note = {CC BY},
}
RIS
TY - JOUR
TI - Retrospective clinical artificial intelligence-assisted study of loaded peri-implant versus edentulous bone
AU - Nicole Riberti
AU - Emira D’Amico
AU - Chiara Cinquini
AU - Michele Furlani
AU - Tania Vanessa Pierfelice
AU - Giovanna Iezzi
AU - Elena Longo
AU - Michele Covelli
AU - Antonio Barone
AU - Alessandra Giuliani
PY - 2026
DA - 2026/07/01
JO - Scientific Reports
DO - 10.1038/s41598-026-64441-8
UR - https://doi.org/10.1038/s41598-026-64441-8
AB - This study aims to clarify the relationship between mechanical stimulation by masticatory loading, bone mineralization distribution (BMD) and osteocyte lacunar shape complexity features (SCFs), through the retrospective clinical analysis of peri-implant bone compared to edentulous bone in human jaws. The multivariate analysis was conducted in two dental contexts: in peri-implant bone, subjected to mechanical forces during chewing, and in edentulous bone, not subjected to masticatory load. The study was conducted by synchrotron radiation high-resolution phase-contrast tomography combined with artificial intelligence (AI)-based image segmentation techniques. Histomorphometry was performed to verify and complement results with additional information on soft tissues. Osteocyte lacunar volume was shown to be significantly larger in the peri-implant group than in the edentulous group. Wide distributions of Aspect Ratio and Sphericity were found in edentulous specimens; this variation was not observed among peri-implant bone samples, suggesting that loading affects peri-implant lacunar SCFs, making them more uniform in shape and size. Lacunar SCFs were found highly correlated with BMD parameters only in the peri-implant (loaded) tissues and not in the edentulous bone. Overall, our results confirm that mechanical loading positively influences osteocyte activity, which suggests that immediate loading of dental implants has a biologic rationale.
SN - 2045-2322
ER -