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Peer-reviewedCC BY 4.0Journal of Clinical Medicine

Quantitative CT Geometry of the Patent Ductus Arteriosus in Infants with Congenital Heart Disease: Association with Aortic Arch Obstruction or Hypoplasia

  • Marian Pop1,2,3
  • Liel Bargutin1
  • Răzvan-Andrei Licu2,4
  • Marian Rotariu2
  • Diana-Ramona Iurian2,4
  • Tania Negovan2,4
  • Horațiu Suciu3,5,6
6 affiliations
  1. 1Faculty of Medicine in English, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142 Târgu Mureș, Romania
  2. 2Radiology and Medical Imaging Laboratory, Mureș County Emergency Clinical Hospital, 540136 Târgu Mureș, Romania
  3. 3Emergency Institute for Cardiovascular Diseases and Transplantation of Târgu Mureș, 540139 Târgu Mureș, Romania
  4. 4Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142 Târgu Mureș, Romania
  5. 5Department of Surgery IV, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142 Târgu Mureș, Romania
  6. 6Clinic of Cardiovascular Surgery, Emergency Institute for Cardiovascular Diseases and Transplantation of Târgu Mureș, 540139 Târgu Mureș, Romania
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Abstract

Background/Objectives: Quantitative patent ductus arteriosus (PDA) geometry in congenital heart disease (CHD), particularly in relation to aortic arch abnormalities, is incompletely characterized. We evaluated CT-derived PDA geometry. Methods: This retrospective exploratory single-center study included 168 infants with CHD and a PDA on cardiovascular CT. Aortic-end, pulmonary-end, and mid-duct diameters and ductal length were measured. The Ductal Length-to-Diameter Index (LDI), selected during exploratory analysis, was defined as ductal length divided by the mean end diameter. Seventy-three patients had CT-documented aortic arch obstruction or hypoplasia. Results: LDI was lower in patients with arch obstruction/hypoplasia than in those without these findings (2.04 [1.39–2.84] vs. 3.51 [2.23–4.89]; p < 0.001; rank-biserial r = −0.473) and remained associated after adjustment for age, weight, and sex (OR per +1 LDI, 0.534; 95% CI, 0.412–0.693; p < 0.001). The association remained robust with a conservative definition restricted to coarctation or interrupted aortic arch. LDI had an interobserver ICC of 0.843 (95% CI, 0.685–0.954), with wide limits of agreement (−1.98 to +2.45). Conclusions: CT-documented aortic arch obstruction or hypoplasia is associated with lower LDI. This exploratory geometric association warrants prospective external validation before clinical use.

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Cite

BibTeXRIS
BibTeX
@article{pop2026quantitative,
  title = {{Quantitative CT Geometry of the Patent Ductus Arteriosus in Infants with Congenital Heart Disease: Association with Aortic Arch Obstruction or Hypoplasia}},
  author = {Marian Pop and Liel Bargutin and Răzvan-Andrei Licu and Marian Rotariu and Diana-Ramona Iurian and Tania Negovan and Horațiu Suciu},
  journal = {Journal of Clinical Medicine},
  year = {2026},
  month = oct,
  doi = {10.3390/jcm15208017},
  url = {https://www.mdpi.com/2077-0383/15/20/8017},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Quantitative CT Geometry of the Patent Ductus Arteriosus in Infants with Congenital Heart Disease: Association with Aortic Arch Obstruction or Hypoplasia
AU  - Marian Pop
AU  - Liel Bargutin
AU  - Răzvan-Andrei Licu
AU  - Marian Rotariu
AU  - Diana-Ramona Iurian
AU  - Tania Negovan
AU  - Horațiu Suciu
PY  - 2026
DA  - 2026/10/01
JO  - Journal of Clinical Medicine
DO  - 10.3390/jcm15208017
UR  - https://www.mdpi.com/2077-0383/15/20/8017
AB  - Background/Objectives: Quantitative patent ductus arteriosus (PDA) geometry in congenital heart disease (CHD), particularly in relation to aortic arch abnormalities, is incompletely characterized. We evaluated CT-derived PDA geometry. Methods: This retrospective exploratory single-center study included 168 infants with CHD and a PDA on cardiovascular CT. Aortic-end, pulmonary-end, and mid-duct diameters and ductal length were measured. The Ductal Length-to-Diameter Index (LDI), selected during exploratory analysis, was defined as ductal length divided by the mean end diameter. Seventy-three patients had CT-documented aortic arch obstruction or hypoplasia. Results: LDI was lower in patients with arch obstruction/hypoplasia than in those without these findings (2.04 [1.39–2.84] vs. 3.51 [2.23–4.89]; p < 0.001; rank-biserial r = −0.473) and remained associated after adjustment for age, weight, and sex (OR per +1 LDI, 0.534; 95% CI, 0.412–0.693; p < 0.001). The association remained robust with a conservative definition restricted to coarctation or interrupted aortic arch. LDI had an interobserver ICC of 0.843 (95% CI, 0.685–0.954), with wide limits of agreement (−1.98 to +2.45). Conclusions: CT-documented aortic arch obstruction or hypoplasia is associated with lower LDI. This exploratory geometric association warrants prospective external validation before clinical use.
SN  - 2077-0383
ER  -