Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 44 min ago
Peer-reviewedCC BY-NCDevelopment & reproduction

Catenin Alpha-Like 1 (CTNNAL1) Modulates Cancer Stem Cell-Associated Properties and Epithelial-Mesenchymal Transition (EMT)-Associated Phenotypes in MDA-MB-231 Breast Cancer Cells.

  • Min Su Kim1
  • Jin Young Jang1
  • Rae-Kwon Kim1
  1. 1Department of Biotechnology, Yong In University, Yongin 17092, Korea.
Read full textPDFDOICite

Abstract

Catenin alpha-like 1 (CTNNAL1) is an adhesion-related protein implicated in cellular plasticity; however, its involvement in cancer stem cell (CSC)-associated properties and epithelial-mesenchymal transition (EMT)-associated phenotypes in breast cancer remains unclear. In this study, we investigated the relationship of CTNNAL1 with CSC-associated properties and EMT-associated phenotypes in MDA-MB-231 breast cancer cells. CTNNAL1 expression increased under sphere-forming conditions together with CSC-associated markers, including CD44, aldehyde dehydrogenase 1 (ALDH1A1), and ALDH1A3. Silencing of CTNNAL1 reduced the expression of these markers and stemness-associated transcription factors, including Sox2, Oct4, and Nanog. CTNNAL1 knockdown also decreased sphere size and sphere-forming efficiency. Furthermore, CTNNAL1 depletion increased E-cadherin expression and decreased N-cadherin, vimentin, and EMT-associated transcription factors, including Snail, Slug, Twist, and ZEB1. CTNNAL1 knockdown also reduced cell migration and invasion. Collectively, these findings suggest that CTNNAL1 is associated with CSC-like properties and EMT-associated phenotypes in MDA-MB-231 breast cancer cells.

Related

  1. Integrative Multi-Omics Reveals TSPAN13 as a Candidate Epithelial–Mesenchymal Transition-Associated Regulator in Prostate Cancer
    Shuo Lu, Houhe Li, Zixiao Zhang +6
    BiomedicinesPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  2. Keratin 17 Defines an Epithelial-Mesenchymal Transition-Associated Migratory Cell State in Pancreatic Ductal Adenocarcinoma
    Shayan Sarkar, Monisankar Ghosh, Lyanne Delgado-Coka +10
    bioRxivPreprintAll rights reservedFull textOncologybioRxivPMC
  3. Human Papillomavirus (HPV) Infection-Associated Epithelial-to-Mesenchymal Transition: Implication in Tumorigenesis and Pathogenesis of HPV-Positive Cancers
    Alexander E. Kabakov, Olga N. Matchuk, Anna V. Khokhlova +1
    CellsPeer-reviewedCC BY 4.0Full textEpidemiology & public healthCrossrefEurope PMC
  4. Development and cross-cohort evaluation of a DLX4-associated epithelial-mesenchymal transition pathomics signature for overall survival in clear cell renal cell carcinoma.
    Guangli Fang, Xinmiao Bao, Jingyu Chang +2
    Translational andrology and urologyPeer-reviewedCC BY-NC-NDFull textOncologyEurope PMC
  5. An epithelial–mesenchymal transition-like synovial stromal-remodeling programme associated with knee osteoarthritis pain: Exploratory transcriptomic discovery and spatial analysis
    Diovanni de Paula Ferreira, Rafael de Negreiros Botan, Wagner R. Martins +1
    PLOS OnePeer-reviewedCC BY 4.0Full textPhysiologyPLOS

Cite

BibTeXRIS
BibTeX
@article{kim2026catenin,
  title = {{Catenin Alpha-Like 1 (CTNNAL1) Modulates Cancer Stem Cell-Associated Properties and Epithelial-Mesenchymal Transition (EMT)-Associated Phenotypes in MDA-MB-231 Breast Cancer Cells.}},
  author = {Min Su Kim and Jin Young Jang and Rae-Kwon Kim},
  journal = {Development \& reproduction},
  year = {2026},
  month = sep,
  doi = {10.12717/dr.2026.30.3.135},
  url = {https://europepmc.org/article/MED/42898851},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Catenin Alpha-Like 1 (CTNNAL1) Modulates Cancer Stem Cell-Associated Properties and Epithelial-Mesenchymal Transition (EMT)-Associated Phenotypes in MDA-MB-231 Breast Cancer Cells.
AU  - Min Su Kim
AU  - Jin Young Jang
AU  - Rae-Kwon Kim
PY  - 2026
DA  - 2026/09/30
JO  - Development & reproduction
DO  - 10.12717/dr.2026.30.3.135
UR  - https://europepmc.org/article/MED/42898851
AB  - Catenin alpha-like 1 (CTNNAL1) is an adhesion-related protein implicated in cellular plasticity; however, its involvement in cancer stem cell (CSC)-associated properties and epithelial-mesenchymal transition (EMT)-associated phenotypes in breast cancer remains unclear. In this study, we investigated the relationship of CTNNAL1 with CSC-associated properties and EMT-associated phenotypes in MDA-MB-231 breast cancer cells. CTNNAL1 expression increased under sphere-forming conditions together with CSC-associated markers, including CD44, aldehyde dehydrogenase 1 (ALDH1A1), and ALDH1A3. Silencing of CTNNAL1 reduced the expression of these markers and stemness-associated transcription factors, including Sox2, Oct4, and Nanog. CTNNAL1 knockdown also decreased sphere size and sphere-forming efficiency. Furthermore, CTNNAL1 depletion increased E-cadherin expression and decreased N-cadherin, vimentin, and EMT-associated transcription factors, including Snail, Slug, Twist, and ZEB1. CTNNAL1 knockdown also reduced cell migration and invasion. Collectively, these findings suggest that CTNNAL1 is associated with CSC-like properties and EMT-associated phenotypes in MDA-MB-231 breast cancer cells.
SN  - 2465-9525
SN  - 2465-9541
ER  -