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Peer-reviewedCC BY 4.0NPJ Parkinson's Disease

The clinical manifestation and neural correlates of cognitive-motor interference in Parkinson’s disease

  • Jingjing Wu1
  • Jingwen Chen1
  • Cheng Zhou1
  • Xiaojun Guan1
  • Tao Guo1
  • Haoting Wu1
  • Chenqing Wu1
  • Jiaqi Wen1
  • Jianmei Qin1
  • Xiaojie Duanmu1
  • Qianshi Zheng1
  • Weijin Yuan1
4 more authors
  • Zihao Zhu1
  • Baorong Zhang2
  • Xiaojun Xu1
  • Minming Zhang1
  1. 1Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
  2. 2Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Abstract

Motor maintenance in Parkinson’s disease (PD) requires cooperation between cognitive and motor function. This study aimed to explore the manifestation and structural correlates of cognitive influence on PD motor. Forty-four normal controls (NCs), 265 probable isolated rapid eye movement behavior disorders patients (pRBD) and 176 PD patients were evaluated with quantitative motor tests. Subject performance under different task complexities was explored. Some subjects were further examined with magnetic resonance imaging (MRI) and analyzed with cognitive-motor interference (CMI) model concentrated on the subcortical regions. We demonstrated that PD patients had difficulty in performing tasks involving both upper and lower limbs, irrespective of task complexities; and as task became harder, they performed worse. However, during early parkinsonian period, subjects with higher educational attainment were associated with less severe motor dysfunction. Further, our findings revalidated the vital role of substantia nigra played in PD pathophysiology and explored the complex and variable association between subcortical structures and CMI across prodromal and clinical stages of parkinsonism.

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Cite

BibTeXRIS
BibTeX
@article{wu2026clinical,
  title = {{The clinical manifestation and neural correlates of cognitive-motor interference in Parkinson’s disease}},
  author = {Jingjing Wu and Jingwen Chen and Cheng Zhou and Xiaojun Guan and Tao Guo and Haoting Wu and Chenqing Wu and Jiaqi Wen and Jianmei Qin and Xiaojie Duanmu and Qianshi Zheng and Weijin Yuan and Zihao Zhu and Baorong Zhang and Xiaojun Xu and Minming Zhang},
  journal = {NPJ Parkinson's Disease},
  year = {2026},
  month = jul,
  doi = {10.1038/s41531-026-01464-y},
  url = {https://doi.org/10.1038/s41531-026-01464-y},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - The clinical manifestation and neural correlates of cognitive-motor interference in Parkinson’s disease
AU  - Jingjing Wu
AU  - Jingwen Chen
AU  - Cheng Zhou
AU  - Xiaojun Guan
AU  - Tao Guo
AU  - Haoting Wu
AU  - Chenqing Wu
AU  - Jiaqi Wen
AU  - Jianmei Qin
AU  - Xiaojie Duanmu
AU  - Qianshi Zheng
AU  - Weijin Yuan
AU  - Zihao Zhu
AU  - Baorong Zhang
AU  - Xiaojun Xu
AU  - Minming Zhang
PY  - 2026
DA  - 2026/07/08
JO  - NPJ Parkinson's Disease
DO  - 10.1038/s41531-026-01464-y
UR  - https://doi.org/10.1038/s41531-026-01464-y
AB  - Motor maintenance in Parkinson’s disease (PD) requires cooperation between cognitive and motor function. This study aimed to explore the manifestation and structural correlates of cognitive influence on PD motor. Forty-four normal controls (NCs), 265 probable isolated rapid eye movement behavior disorders patients (pRBD) and 176 PD patients were evaluated with quantitative motor tests. Subject performance under different task complexities was explored. Some subjects were further examined with magnetic resonance imaging (MRI) and analyzed with cognitive-motor interference (CMI) model concentrated on the subcortical regions. We demonstrated that PD patients had difficulty in performing tasks involving both upper and lower limbs, irrespective of task complexities; and as task became harder, they performed worse. However, during early parkinsonian period, subjects with higher educational attainment were associated with less severe motor dysfunction. Further, our findings revalidated the vital role of substantia nigra played in PD pathophysiology and explored the complex and variable association between subcortical structures and CMI across prodromal and clinical stages of parkinsonism.
SN  - 2373-8057
ER  -