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Peer-reviewedCC BYScience Advances

Neurophysiological dynamics related to perception, action, and language in schizophrenia

  • Hsi T. Wei1,2
  • Dominic Boutet3
  • Rukun Dou2,4
  • Jessica Ahrens2,5
  • Nadia Zeramdini2
  • Alban Voppel1,2
  • Fernando Gonzales-Aste1
  • Fatme Abboud2
  • Sylvain Baillet3,6,7
  • Lena Palaniyappan1,2
7 affiliations
  1. 1Department of Psychiatry, McGill University, Montreal, QC, Canada.
  2. 2Douglas Research Centre, McGill University, Montreal, QC, Canada.
  3. 3Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
  4. 4Faculty of Medicine, McGill University, Montreal, QC, Canada.
  5. 5Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada.
  6. 6Centre de recherche du Centre hospitalier de l’Université de Montréal.
  7. 7Department of Neuroscience, University of Montreal, Montreal, QC, Canada.
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Abstract

Schizophrenia disrupts both how people perceive the world and how they express and act on their thoughts, yet these symptoms are usually studied separately. Using magnetoencephalography during multisensory and motor tasks, we tested whether reduced event-related beta-band (15 to 30 hertz) modulation, a signal implicated in predictive control, provides a candidate neural marker across these domains. Compared to healthy individuals, patients showed diminished beta changes during sensory processing and movement completion, suggesting reduced flexibility in updating internal models. This neural pattern covaried with audiovisual simultaneity-judgment behavior, disorganized natural speech, and greater clinical severity. These findings suggest that distributed beta modulation may serve as a candidate cross-domain marker associated with perceptual, motor, and language disturbances in schizophrenia, motivating future studies that directly test predictive updating mechanisms.

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Cite

BibTeXRIS
BibTeX
@article{wei2026neurophysiological,
  title = {{Neurophysiological dynamics related to perception, action, and language in schizophrenia}},
  author = {Hsi T. Wei and Dominic Boutet and Rukun Dou and Jessica Ahrens and Nadia Zeramdini and Alban Voppel and Fernando Gonzales-Aste and Fatme Abboud and Sylvain Baillet and Lena Palaniyappan},
  journal = {Science Advances},
  year = {2026},
  month = oct,
  doi = {10.1126/sciadv.aeh5819},
  url = {https://www.science.org/doi/10.1126/sciadv.aeh5819},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Neurophysiological dynamics related to perception, action, and language in schizophrenia
AU  - Hsi T. Wei
AU  - Dominic Boutet
AU  - Rukun Dou
AU  - Jessica Ahrens
AU  - Nadia Zeramdini
AU  - Alban Voppel
AU  - Fernando Gonzales-Aste
AU  - Fatme Abboud
AU  - Sylvain Baillet
AU  - Lena Palaniyappan
PY  - 2026
DA  - 2026/10/21
JO  - Science Advances
DO  - 10.1126/sciadv.aeh5819
UR  - https://www.science.org/doi/10.1126/sciadv.aeh5819
AB  - Schizophrenia disrupts both how people perceive the world and how they express and act on their thoughts, yet these symptoms are usually studied separately. Using magnetoencephalography during multisensory and motor tasks, we tested whether reduced event-related beta-band (15 to 30 hertz) modulation, a signal implicated in predictive control, provides a candidate neural marker across these domains. Compared to healthy individuals, patients showed diminished beta changes during sensory processing and movement completion, suggesting reduced flexibility in updating internal models. This neural pattern covaried with audiovisual simultaneity-judgment behavior, disorganized natural speech, and greater clinical severity. These findings suggest that distributed beta modulation may serve as a candidate cross-domain marker associated with perceptual, motor, and language disturbances in schizophrenia, motivating future studies that directly test predictive updating mechanisms.
SN  - 2375-2548
ER  -