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Peer-reviewedCC BYScientific Reports

Impaired left ventricular transmural strain gradient linked to septal flash in complete left bundle branch block

  • Jie Xiao1
  • Hongda Su1
  • Wanqing Hou1
  • Shengnan Lin1
  • Runzi Ling1
  • Yongqi Zheng1
  • Xiaojian Ye1
  • Lei Yan1
  1. 1Department of Ultrasound, The First Affiliated Hospital, Fujian Medical University
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Abstract

This study used layer-specific speckle-tracking imaging (LS-STI) to investigate alterations in the left ventricular transmural contractile gradient and its correlation with septal flash (SF) parameters in patients with complete left bundle branch block (CLBBB). This study included 116 CLBBB patients (37 without SF, 79 with SF) and 40 matched controls. Using LS-STI, we measured the left ventricular global longitudinal systolic peak strain (GLS) and the longitudinal systolic peak strain of the endocardial, mid-myocardial, and epicardial layers (GLS-Endo, GLS-Mid, and GLS-Epi). The strain gradient through the left ventricular wall (transmural gradient, TG) was subsequently calculated. Spearman correlation analysis was used to determine the correlations of SF amplitude and SF duration with systolic strain parameters, particularly the TG. Compared with the non-SF group, the SF group had lower myocardial systolic longitudinal strain in all layers (GLS-Endo: -16.83 ± 4.89% vs. -20.88 ± 3.24%; GLS-Mid: -14.71 ± 4.38% vs. -18.24 ± 2.80%; GLS-Epi: -12.77 ± 3.84% vs. -15.82 ± 2.44%) and transmural gradient (TG: 4.05 ± 1.19 vs. 5.06 ± 1.09) (all P < 0.05). TG was negatively correlated with both SF amplitude and SF duration (r = -0.25, P = 0.027 for amplitude; r = -0.47, P < 0.001 for duration). In CLBBB patients with SF, the left ventricular transmural contractile gradient was more severely impaired, and SF duration was moderately correlated with layer‑specific strain and the transmural gradient. However, its independent or incremental predictive value needs to be further validated.

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Cite

BibTeXRIS
BibTeX
@article{xiao2026impaired,
  title = {{Impaired left ventricular transmural strain gradient linked to septal flash in complete left bundle branch block}},
  author = {Jie Xiao and Hongda Su and Wanqing Hou and Shengnan Lin and Runzi Ling and Yongqi Zheng and Xiaojian Ye and Lei Yan},
  journal = {Scientific Reports},
  year = {2026},
  month = jul,
  doi = {10.1038/s41598-026-61335-7},
  url = {https://doi.org/10.1038/s41598-026-61335-7},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Impaired left ventricular transmural strain gradient linked to septal flash in complete left bundle branch block
AU  - Jie Xiao
AU  - Hongda Su
AU  - Wanqing Hou
AU  - Shengnan Lin
AU  - Runzi Ling
AU  - Yongqi Zheng
AU  - Xiaojian Ye
AU  - Lei Yan
PY  - 2026
DA  - 2026/07/01
JO  - Scientific Reports
DO  - 10.1038/s41598-026-61335-7
UR  - https://doi.org/10.1038/s41598-026-61335-7
AB  - This study used layer-specific speckle-tracking imaging (LS-STI) to investigate alterations in the left ventricular transmural contractile gradient and its correlation with septal flash (SF) parameters in patients with complete left bundle branch block (CLBBB). This study included 116 CLBBB patients (37 without SF, 79 with SF) and 40 matched controls. Using LS-STI, we measured the left ventricular global longitudinal systolic peak strain (GLS) and the longitudinal systolic peak strain of the endocardial, mid-myocardial, and epicardial layers (GLS-Endo, GLS-Mid, and GLS-Epi). The strain gradient through the left ventricular wall (transmural gradient, TG) was subsequently calculated. Spearman correlation analysis was used to determine the correlations of SF amplitude and SF duration with systolic strain parameters, particularly the TG. Compared with the non-SF group, the SF group had lower myocardial systolic longitudinal strain in all layers (GLS-Endo: -16.83 ± 4.89% vs. -20.88 ± 3.24%; GLS-Mid: -14.71 ± 4.38% vs. -18.24 ± 2.80%; GLS-Epi: -12.77 ± 3.84% vs. -15.82 ± 2.44%) and transmural gradient (TG: 4.05 ± 1.19 vs. 5.06 ± 1.09) (all P < 0.05). TG was negatively correlated with both SF amplitude and SF duration (r = -0.25, P = 0.027 for amplitude; r = -0.47, P < 0.001 for duration). In CLBBB patients with SF, the left ventricular transmural contractile gradient was more severely impaired, and SF duration was moderately correlated with layer‑specific strain and the transmural gradient. However, its independent or incremental predictive value needs to be further validated.
SN  - 2045-2322
ER  -