Pre-surgery statin use and outcomes in operated chronic subdural haematomas: a nationwide cohort study.
10 affiliations
- 1Neurocenter, Department of Neurosurgery, Turku University Hospital, Turku, Finland.
- 2Neurosurgery, Clinical Neurosciences, University of Turku, Turku, Finland.
- 3Institute of Biomedicine, University of Turku, Turku, Finland.
- 4Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland.
- 5Neurocenter, Department of Neurology, Turku University Hospital, Turku, Finland.
- 6Neurology, Clinical Neurosciences, University of Turku, Turku, Finland.
- 7Department of Neurosurgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
- 8Department of Neurosurgery, Tampere University Hospital, Tampere University, Tampere, Finland.
- 9Clinical Research Center, Turku University Hospital, Turku, Finland.
- 10Heart Centre, Turku University Hospital and University of Turku, Turku, Finland.
Abstract
Background
Chronic subdural haematoma (cSDH) is common in older adults, and medication exposures may influence postoperative outcomes. We assessed whether pre-surgery statin use is associated with short- and long-term outcomes.Methods
We conducted a nationwide registry study of adults undergoing surgical evacuation of traumatic or non-traumatic cSDH (6/2004-12/2018) in Finnish university hospitals. Pre-surgery statin use was defined from national prescription records using a pill-counting approach. The primary outcome was 30-day all-cause mortality. Secondary outcomes were 30-day reoperation and length of hospital stay. Tertiary outcomes were 1-year mortality and reoperation. Mortality was analysed using Cox regression; reoperation with Fine-Gray models accounting for competing risk of death.Results
The cohort included 9001 patients, of whom 2450 (27.2%) used statins. Thirty-day mortality was 3.3% in statin users and 4.5% in non-users, with lower adjusted mortality among statin users (HR 0.57; 95% CI 0.44-0.73). Reoperation within 30 days (n = 897) was similar between groups (sub-distribution HR 1.08; 95% CI 0.97-1.21). Hospital stay was shorter in statin users (22.1 ± 62.7 vs 26.3 ± 77.5 days; adjusted P = .002). At 1 year, mortality remained lower in statin users (13.3% vs 15.4%; HR 0.66; 95% CI 0.58-0.75), with no difference in reoperation (sub-distribution HR 1.09; 95% CI 0.96-1.22).Conclusion
In this nationwide cohort of surgically treated cSDH patients, pre-surgery statin use was associated with lower short- and long-term mortality and shorter hospital stay, while reoperation rates were similar between statin users and non-users.
Related
- Spontaneous Intracranial Hypotension with Bilateral Subdural Haematomas and Posterior Cerebral Artery Infarcts with Delayed Epidural Blood Patch Response: A Case Report
- Risk factors and clinical outcomes for acute kidney injury after surgery for primary spinal and pelvic bone tumours: Analysis of the US Nationwide Inpatient Sample 2005–2020
- Comparative outcomes of middle meningeal artery embolization, burr hole drainage, and neuroendoscopic-assisted evacuation with MMA disconnection for chronic subdural haematoma: a multicenter retrospective cohort study
- Real‐World Treatment Escalation Patterns of Biologics and Functional Endoscopic Sinus Surgery in Chronic Rhinosinusitis (CRS): A Nationwide Database Study
- Regional disparities in lung cancer surgery and survival in South Korea: a nationwide population-based retrospective cohort study using linked cancer registry and national health insurance data
BibTeX
@article{posti2026presurgery,
title = {{Pre-surgery statin use and outcomes in operated chronic subdural haematomas: a nationwide cohort study.}},
author = {Jussi P Posti and Aleksi Tornio and Jori O Ruuskanen and Rahul Raj and Teemu Luoto and Pihla Tommiska and Ville Kytö},
journal = {Age and ageing},
year = {2026},
month = aug,
doi = {10.1093/ageing/afag296},
url = {https://europepmc.org/article/MED/42910913},
note = {CC BY},
}
RIS
TY - JOUR
TI - Pre-surgery statin use and outcomes in operated chronic subdural haematomas: a nationwide cohort study.
AU - Jussi P Posti
AU - Aleksi Tornio
AU - Jori O Ruuskanen
AU - Rahul Raj
AU - Teemu Luoto
AU - Pihla Tommiska
AU - Ville Kytö
PY - 2026
DA - 2026/08/01
JO - Age and ageing
DO - 10.1093/ageing/afag296
UR - https://europepmc.org/article/MED/42910913
AB - Background Chronic subdural haematoma (cSDH) is common in older adults, and medication exposures may influence postoperative outcomes. We assessed whether pre-surgery statin use is associated with short- and long-term outcomes.Methods We conducted a nationwide registry study of adults undergoing surgical evacuation of traumatic or non-traumatic cSDH (6/2004-12/2018) in Finnish university hospitals. Pre-surgery statin use was defined from national prescription records using a pill-counting approach. The primary outcome was 30-day all-cause mortality. Secondary outcomes were 30-day reoperation and length of hospital stay. Tertiary outcomes were 1-year mortality and reoperation. Mortality was analysed using Cox regression; reoperation with Fine-Gray models accounting for competing risk of death.Results The cohort included 9001 patients, of whom 2450 (27.2%) used statins. Thirty-day mortality was 3.3% in statin users and 4.5% in non-users, with lower adjusted mortality among statin users (HR 0.57; 95% CI 0.44-0.73). Reoperation within 30 days (n = 897) was similar between groups (sub-distribution HR 1.08; 95% CI 0.97-1.21). Hospital stay was shorter in statin users (22.1 ± 62.7 vs 26.3 ± 77.5 days; adjusted P = .002). At 1 year, mortality remained lower in statin users (13.3% vs 15.4%; HR 0.66; 95% CI 0.58-0.75), with no difference in reoperation (sub-distribution HR 1.09; 95% CI 0.96-1.22).Conclusion In this nationwide cohort of surgically treated cSDH patients, pre-surgery statin use was associated with lower short- and long-term mortality and shorter hospital stay, while reoperation rates were similar between statin users and non-users.
SN - 0002-0729
SN - 1468-2834
ER -