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Peer-reviewedCC BYCureus

Primary Hepatic Neuroblastoma: A Case Report of a Solitary Liver Mass in an Adolescent Male

  • Mais Jazazi1
  • Ruba Alhazaimeh1
  • Ayman Alhwayan1
  • Mohammed Alsmadi2
  • Atwa Altawarh1
  • Suliman Aljaafreh1
  • Ruba Y Shannaq3
  • Khaled Alshar4
  • Maher Khader1
4 affiliations
  1. 1Department of Paediatric Haematology-Oncology, Royal Medical Services - Queen Rania Children’s Hospital, Amman, JOR
  2. 2Department of Paediatric Radiology, Royal Medical Services - Queen Rania Children’s Hospital, Amman, JOR
  3. 3Department of Pathology and Laboratory Medicine, Royal Medical Services - Princess Iman Center for Research and Laboratory, Amman, JOR
  4. 4Department of Paediatric Surgery, Royal Medical Services - Queen Rania Children’s Hospital, Amman, JOR
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Abstract

Primary hepatic neuroblastoma (PHN) is an exceptionally rare subtype of neuroblastoma. Neuroblastoma typically arises in tissues of the sympathetic nervous system, and hepatic metastases are more common than PHN. We present a 12-year-old male who presented with abdominal discomfort. Imaging revealed hepatomegaly with a solitary mass in segment V of the liver. After total resection, histopathological analysis identified a poorly differentiated neuroblastoma with a low mitotic-karyorrhectic index (<2%) and absence of neuroblastoma (MYCN) gene amplification (International Neuroblastoma Staging System, stage 1).

This case is notable for the patient's age, successful surgical outcome, and mass confinement of the liver. Despite poor cellular differentiation yielding an unfavorable histological grade, the localized Stage 1 disease and absence of MYCN amplification supported an individualized approach resulting in the absence of disease recurrence for 18 months postoperatively without chemotherapy. PHN should be considered in the differential diagnosis for children presenting with a solitary liver mass, regardless of age.

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Cite

BibTeXRIS
BibTeX
@article{jazazi2026primary,
  title = {{Primary Hepatic Neuroblastoma: A Case Report of a Solitary Liver Mass in an Adolescent Male}},
  author = {Mais Jazazi and Ruba Alhazaimeh and Ayman Alhwayan and Mohammed Alsmadi and Atwa Altawarh and Suliman Aljaafreh and Ruba Y Shannaq and Khaled Alshar and Maher Khader},
  journal = {Cureus},
  year = {2026},
  month = oct,
  doi = {10.7759/cureus.117304},
  url = {https://europepmc.org/article/PMC/PMC13723323},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Primary Hepatic Neuroblastoma: A Case Report of a Solitary Liver Mass in an Adolescent Male
AU  - Mais Jazazi
AU  - Ruba Alhazaimeh
AU  - Ayman Alhwayan
AU  - Mohammed Alsmadi
AU  - Atwa Altawarh
AU  - Suliman Aljaafreh
AU  - Ruba Y Shannaq
AU  - Khaled Alshar
AU  - Maher Khader
PY  - 2026
DA  - 2026/10/01
JO  - Cureus
DO  - 10.7759/cureus.117304
UR  - https://europepmc.org/article/PMC/PMC13723323
AB  - Primary hepatic neuroblastoma (PHN) is an exceptionally rare subtype of neuroblastoma. Neuroblastoma typically arises in tissues of the sympathetic nervous system, and hepatic metastases are more common than PHN. We present a 12-year-old male who presented with abdominal discomfort. Imaging revealed hepatomegaly with a solitary mass in segment V of the liver. After total resection, histopathological analysis identified a poorly differentiated neuroblastoma with a low mitotic-karyorrhectic index (<2%) and absence of neuroblastoma (MYCN) gene amplification (International Neuroblastoma Staging System, stage 1).  This case is notable for the patient's age, successful surgical outcome, and mass confinement of the liver. Despite poor cellular differentiation yielding an unfavorable histological grade, the localized Stage 1 disease and absence of MYCN amplification supported an individualized approach resulting in the absence of disease recurrence for 18 months postoperatively without chemotherapy. PHN should be considered in the differential diagnosis for children presenting with a solitary liver mass, regardless of age.
SN  - 2168-8184
ER  -