Genetic analyses of blood pressure traits in 140,000 admixed adults from Mexico City
- 1Clinical Trial Service Unit and Epidemiological Studies Unit, Oxford Population Health, University of Oxford, OX3 7LF, UK
Abstract
Blood pressure (BP) is a major, heritable determinant of cardiometabolic health. Genome-wide association studies (GWAS) have identified thousands of BP-influencing genetic variants. People of admixed American (AMR) ancestry harbour variants that are rare in other populations yet remain understudied in GWAS. Here, we perform GWAS of four BP traits in 140,559 participants from the Mexico City Prospective Study. Conditional analyses identified 78 independent signals for systolic BP, 61 for diastolic BP, 88 for mean arterial pressure and 24 for pulse pressure. Trans-ancestry meta-analysis externally replicated 13 novel signals, and six more replicated in AMR-ancestry meta-analysis. Overall, we found significant heterogeneity between AMR and other ancestries at nine loci. Functional integration analyses implicated the heart, arterial tree, adrenal glands, and kidney in BP regulation. Analysis of exome-sequenced rare variants identified genes that may act through kidney and endothelial function. The results underscore the value of including diverse populations in genetic discovery.
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BibTeX
@misc{turner2026genetic,
title = {{Genetic analyses of blood pressure traits in 140,000 admixed adults from Mexico City}},
author = {M. Turner and J. Berumen and S. Morris and D. Aguilar-Ramirez and L. Fernandez-Chirino and T. Oreskovic and P. Baca and E. Barrera and F. Rivas and L. Gnatiuc Friedrichs and M. Hill and E. Trichia and A. Vergara-Lope and R. Wade and E. Mayerhofer and M. Riaz and I. Y. Millwood and R. G. Walters and A. Pozarickij and J. I. Rotter and J. Yao and H. J. Lin and X. Guo and N. Staplin and P. Kuri-Morales and R. Haynes and J. Alegre-Diaz and J. R. Emberson and R. Tapi-Conyer and J. M. Torres},
howpublished = {medRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.17.26363296},
url = {https://www.medrxiv.org/content/10.64898/2026.09.17.26363296v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - Genetic analyses of blood pressure traits in 140,000 admixed adults from Mexico City
AU - M. Turner
AU - J. Berumen
AU - S. Morris
AU - D. Aguilar-Ramirez
AU - L. Fernandez-Chirino
AU - T. Oreskovic
AU - P. Baca
AU - E. Barrera
AU - F. Rivas
AU - L. Gnatiuc Friedrichs
AU - M. Hill
AU - E. Trichia
AU - A. Vergara-Lope
AU - R. Wade
AU - E. Mayerhofer
AU - M. Riaz
AU - I. Y. Millwood
AU - R. G. Walters
AU - A. Pozarickij
AU - J. I. Rotter
AU - J. Yao
AU - H. J. Lin
AU - X. Guo
AU - N. Staplin
AU - P. Kuri-Morales
AU - R. Haynes
AU - J. Alegre-Diaz
AU - J. R. Emberson
AU - R. Tapi-Conyer
AU - J. M. Torres
PY - 2026
DA - 2026/09/17
PB - medRxiv
DO - 10.64898/2026.09.17.26363296
UR - https://www.medrxiv.org/content/10.64898/2026.09.17.26363296v1
AB - Blood pressure (BP) is a major, heritable determinant of cardiometabolic health. Genome-wide association studies (GWAS) have identified thousands of BP-influencing genetic variants. People of admixed American (AMR) ancestry harbour variants that are rare in other populations yet remain understudied in GWAS. Here, we perform GWAS of four BP traits in 140,559 participants from the Mexico City Prospective Study. Conditional analyses identified 78 independent signals for systolic BP, 61 for diastolic BP, 88 for mean arterial pressure and 24 for pulse pressure. Trans-ancestry meta-analysis externally replicated 13 novel signals, and six more replicated in AMR-ancestry meta-analysis. Overall, we found significant heterogeneity between AMR and other ancestries at nine loci. Functional integration analyses implicated the heart, arterial tree, adrenal glands, and kidney in BP regulation. Analysis of exome-sequenced rare variants identified genes that may act through kidney and endothelial function. The results underscore the value of including diverse populations in genetic discovery.
ER -