Predictors of Time to Start of Trophic Feeding in Preterm Neonates Admitted to Neonatal Intensive Care Unit of Adama Hospital Medical College, Ethiopia: A Retrospective Cohort Study
- 1Public Health Institute
Abstract
BackgroundEarly trophic feeding promotes gut maturation, feeding tolerance, and growth in preterm neonates. However, delays remain common despite recommendations for initiation within 24 hours of birth, especially in resource-limited settings. Evidence on feeding initiation timing and predictors among Ethiopian preterm neonates is limited.
ObjectiveTo determine time to trophic feeding initiation and identify predictors among preterm neonates admitted to Adama Hospital Medical College, Ethiopia.
MethodsA hospital-based retrospective cohort study was performed on 436 randomly chosen preterm neonates admitted to NICU. Data extraction was performed using a structured checklist. Time to trophic feeding initiation was analyzed using Kaplan-Meier estimates, log-rank tests, and bivariable and multivariable Cox regression models . Adjusted hazard ratios with 95% CIs were reported.
ResultsThe sample comprised 416 preterm neonates, of whom 311 (74.8%) started trophic feeding during follow-up, and 105 (25.2%) were censored. The rate of initiation of trophic feeding was 1.92 per 100 person-hours (95% CI 1.72 to 2.15). Median time to initiation was 42 hours (interquartile range 24 to 50). Independent predictors of feeding initiation were determined by multivariable analysis and included gestational age, birth weight, maternal anaemia, respiratory distress syndrome and necrotising enterocolitis. Neonates born at 34-36 weeks had earlier initiation than those born at <34 weeks (AHR 1.39; 95 % CI 1.09 to 1.78). Similarly, neonates with a birth weight of [≥]1500 g had an earlier initiation than those with a birth weight of <1500 g (AHR 1.41; 95% CI 1.04 to 1.91). Delayed initiation was associated with maternal anaemia (AHR 0.70; 95% CI 0.51-0.95), respiratory distress syndrome (AHR 0.67; 95% CI 0.51-0.88) and necrotising enterocolitis (AHR 0.48; 95% CI 0.33-0.69).
ConclusionsDelayed trophic feeding remains common among preterm neonates. Standardized feeding protocols, strengthened maternal care, and individualized nutrition strategies are needed to improve neonatal outcomes in study area.
Key messages1. What is already known about the subject?{checkmark} {square}Early trophic feeding aids in intestinal maturation, improves feeding tolerance and reduces the complications of long-term nutritional deprivation in preterm infants.
{checkmark} {square}International recommendations advocate that minimal enteral feeding should be started within the first 24 hours of life whenever clinically feasible.
{checkmark}Delayed trophic feeding is still a common practice in neonatal intensive care units particularly in low resource settings. However, there is scanty evidence on determinants of delayed initiation in Ethiopia.
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BibTeX
@misc{misha2026predictors,
title = {{Predictors of Time to Start of Trophic Feeding in Preterm Neonates Admitted to Neonatal Intensive Care Unit of Adama Hospital Medical College, Ethiopia: A Retrospective Cohort Study}},
author = {B. Misha and G. A. Dassie and I. Mohammad},
howpublished = {medRxiv},
year = {2026},
month = aug,
doi = {10.64898/2026.08.26.26361481},
url = {https://www.medrxiv.org/content/10.64898/2026.08.26.26361481v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - Predictors of Time to Start of Trophic Feeding in Preterm Neonates Admitted to Neonatal Intensive Care Unit of Adama Hospital Medical College, Ethiopia: A Retrospective Cohort Study
AU - B. Misha
AU - G. A. Dassie
AU - I. Mohammad
PY - 2026
DA - 2026/08/26
PB - medRxiv
DO - 10.64898/2026.08.26.26361481
UR - https://www.medrxiv.org/content/10.64898/2026.08.26.26361481v1
AB - BackgroundEarly trophic feeding promotes gut maturation, feeding tolerance, and growth in preterm neonates. However, delays remain common despite recommendations for initiation within 24 hours of birth, especially in resource-limited settings. Evidence on feeding initiation timing and predictors among Ethiopian preterm neonates is limited. ObjectiveTo determine time to trophic feeding initiation and identify predictors among preterm neonates admitted to Adama Hospital Medical College, Ethiopia. MethodsA hospital-based retrospective cohort study was performed on 436 randomly chosen preterm neonates admitted to NICU. Data extraction was performed using a structured checklist. Time to trophic feeding initiation was analyzed using Kaplan-Meier estimates, log-rank tests, and bivariable and multivariable Cox regression models . Adjusted hazard ratios with 95% CIs were reported. ResultsThe sample comprised 416 preterm neonates, of whom 311 (74.8%) started trophic feeding during follow-up, and 105 (25.2%) were censored. The rate of initiation of trophic feeding was 1.92 per 100 person-hours (95% CI 1.72 to 2.15). Median time to initiation was 42 hours (interquartile range 24 to 50). Independent predictors of feeding initiation were determined by multivariable analysis and included gestational age, birth weight, maternal anaemia, respiratory distress syndrome and necrotising enterocolitis. Neonates born at 34-36 weeks had earlier initiation than those born at <34 weeks (AHR 1.39; 95 % CI 1.09 to 1.78). Similarly, neonates with a birth weight of [≥]1500 g had an earlier initiation than those with a birth weight of <1500 g (AHR 1.41; 95% CI 1.04 to 1.91). Delayed initiation was associated with maternal anaemia (AHR 0.70; 95% CI 0.51-0.95), respiratory distress syndrome (AHR 0.67; 95% CI 0.51-0.88) and necrotising enterocolitis (AHR 0.48; 95% CI 0.33-0.69). ConclusionsDelayed trophic feeding remains common among preterm neonates. Standardized feeding protocols, strengthened maternal care, and individualized nutrition strategies are needed to improve neonatal outcomes in study area. Key messages1. What is already known about the subject?{checkmark} {square}Early trophic feeding aids in intestinal maturation, improves feeding tolerance and reduces the complications of long-term nutritional deprivation in preterm infants. {checkmark} {square}International recommendations advocate that minimal enteral feeding should be started within the first 24 hours of life whenever clinically feasible. {checkmark}Delayed trophic feeding is still a common practice in neonatal intensive care units particularly in low resource settings. However, there is scanty evidence on determinants of delayed initiation in Ethiopia.
ER -