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Peer-reviewedCC BYCase reports in surgery

Gastric Spindle Cell Neoplasm With LMNA::NTRK1 Fusion: A Rare Mimic of Wild-Type GIST.

  • Yoonji Seo1,2
  • Christopher Leung2
  • Mitali Fadia1,3
  • Christopher Seng Hong Lim1,2
  • Sivakumar Gananadha1,2
  1. 1School of Medicine and Psychology The Australian National University Canberra 2601 Australian Capital Territory Australia anu.edu.au.
  2. 2Department of Surgery The Canberra Hospital Yamba Drive Garran 2605 Australian Capital Territory Australia health.act.gov.au.
  3. 3Department of Anatomical Pathology The Canberra Hospital Yamba Drive Garran 2605 Australian Capital Territory Australia health.act.gov.au.
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Abstract

Neurotrophic tyrosine receptor kinase-rearranged spindle cell neoplasms (NTRK-SCNs) are rare mesenchymal tumours defined by oncogenic rearrangements involving NTRK genes. NTRK fusions are exceedingly rare in the gastrointestinal tract and can closely resemble wild-type gastrointestinal stromal tumours (GISTs), posing a diagnostic challenge in the absence of molecular testing. We report a case of a 36-year-old woman with a distal gastric mass initially suspected to be a GIST. Surgical resection revealed a spindle cell tumour with low mitotic activity and perivascular hyalinisation. Immunohistochemistry demonstrated expression of CD34, S100 and pan-TRK and was negative for KIT/CD117 and DOG1. Molecular testing confirmed an LMNA::NTRK1 fusion, consistent with NTRK-SCN. This case highlights the importance of considering NTRK-SCN in KIT/DOG1-negative gastric spindle cell tumours.

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Cite

BibTeXRIS
BibTeX
@article{seo2026gastric,
  title = {{Gastric Spindle Cell Neoplasm With LMNA::NTRK1 Fusion: A Rare Mimic of Wild-Type GIST.}},
  author = {Yoonji Seo and Christopher Leung and Mitali Fadia and Christopher Seng Hong Lim and Sivakumar Gananadha},
  journal = {Case reports in surgery},
  year = {2026},
  month = oct,
  doi = {10.1155/cris/5492086},
  url = {https://europepmc.org/article/MED/42923622},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Gastric Spindle Cell Neoplasm With LMNA::NTRK1 Fusion: A Rare Mimic of Wild-Type GIST.
AU  - Yoonji Seo
AU  - Christopher Leung
AU  - Mitali Fadia
AU  - Christopher Seng Hong Lim
AU  - Sivakumar Gananadha
PY  - 2026
DA  - 2026/10/21
JO  - Case reports in surgery
DO  - 10.1155/cris/5492086
UR  - https://europepmc.org/article/MED/42923622
AB  - Neurotrophic tyrosine receptor kinase-rearranged spindle cell neoplasms (NTRK-SCNs) are rare mesenchymal tumours defined by oncogenic rearrangements involving NTRK genes. NTRK fusions are exceedingly rare in the gastrointestinal tract and can closely resemble wild-type gastrointestinal stromal tumours (GISTs), posing a diagnostic challenge in the absence of molecular testing. We report a case of a 36-year-old woman with a distal gastric mass initially suspected to be a GIST. Surgical resection revealed a spindle cell tumour with low mitotic activity and perivascular hyalinisation. Immunohistochemistry demonstrated expression of CD34, S100 and pan-TRK and was negative for KIT/CD117 and DOG1. Molecular testing confirmed an LMNA::NTRK1 fusion, consistent with NTRK-SCN. This case highlights the importance of considering NTRK-SCN in KIT/DOG1-negative gastric spindle cell tumours.
SN  - 2090-6900
SN  - 2090-6919
ER  -