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Peer-reviewedCC BY-NC 4.0Journal of Neurogastroenterology and Motility

Delayed Gastric Emptying Is Associated With Progression to End-Stage Renal Disease in Diabetic Patients With Chronic Upper Gastrointestinal Symptoms

  • Jin Ook Chung1
  • Seon-Young Park1
  • Hyun-Soo Kim1
  • Dong Jin Chung1
  1. 1Department of Internal Medicine, Chonnam National University Medical School Gwangju Korea
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Abstract

Background/Aims: This study aimed to investigate whether delayed gastric emptying (GE) is associated with progression to end-stage renal disease (ESRD) in diabetic patients with chronic upper gastrointestinal (UGI) symptoms.

Methods: We extracted data on demographics, UGI symptoms, GE study, and renal outcome from the medical records of diabetic patients with chronic UGI symptoms who underwent a GE study over 17 years. Renal outcome was defined as the development of ESRD. An association between delayed GE and renal outcome was investigated using a Cox proportional hazards regression model with Firth’s correction.

Results: Among 515 subjects who had undergone a GE study, 100 patients with type 1 or type 2 diabetes (67 females, 85 with type 2 diabetes, median age 63 years) were included. Of the 100 patients, 53 had delayed GE. During the follow-up (median, 264 weeks), 25 patients with diabetes developed ESRD. The Firth-penalized Cox regression model showed that delayed GE was significantly associated with renal outcome in diabetic patients with chronic UGI symptoms (hazard ratio 3.12; 95% confidence interval 1.34–7.97; P = 0.008). The 5-year cumulative incidence of renal outcome was approximately 9% in patients with normal GE and 35% in those with delayed GE (log-rank P = 0.021).

Conclusions: Delayed GE was associated with progression to ESRD in diabetic patients with chronic UGI symptoms.

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Cite

BibTeXRIS
BibTeX
@article{chung2026delayed,
  title = {{Delayed Gastric Emptying Is Associated With Progression to End-Stage Renal Disease in Diabetic Patients With Chronic Upper Gastrointestinal Symptoms}},
  author = {Jin Ook Chung and Seon-Young Park and Hyun-Soo Kim and Dong Jin Chung},
  journal = {Journal of Neurogastroenterology and Motility},
  year = {2026},
  month = oct,
  doi = {10.5056/jnm25188},
  url = {https://doi.org/10.5056/jnm25188},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Delayed Gastric Emptying Is Associated With Progression to End-Stage Renal Disease in Diabetic Patients With Chronic Upper Gastrointestinal Symptoms
AU  - Jin Ook Chung
AU  - Seon-Young Park
AU  - Hyun-Soo Kim
AU  - Dong Jin Chung
PY  - 2026
DA  - 2026/10/31
JO  - Journal of Neurogastroenterology and Motility
DO  - 10.5056/jnm25188
UR  - https://doi.org/10.5056/jnm25188
AB  - Background/Aims: This study aimed to investigate whether delayed gastric emptying (GE) is associated with progression to end-stage renal disease (ESRD) in diabetic patients with chronic upper gastrointestinal (UGI) symptoms.  Methods: We extracted data on demographics, UGI symptoms, GE study, and renal outcome from the medical records of diabetic patients with chronic UGI symptoms who underwent a GE study over 17 years. Renal outcome was defined as the development of ESRD. An association between delayed GE and renal outcome was investigated using a Cox proportional hazards regression model with Firth’s correction.  Results: Among 515 subjects who had undergone a GE study, 100 patients with type 1 or type 2 diabetes (67 females, 85 with type 2 diabetes, median age 63 years) were included. Of the 100 patients, 53 had delayed GE. During the follow-up (median, 264 weeks), 25 patients with diabetes developed ESRD. The Firth-penalized Cox regression model showed that delayed GE was significantly associated with renal outcome in diabetic patients with chronic UGI symptoms (hazard ratio 3.12; 95% confidence interval 1.34–7.97; P = 0.008). The 5-year cumulative incidence of renal outcome was approximately 9% in patients with normal GE and 35% in those with delayed GE (log-rank P = 0.021).  Conclusions: Delayed GE was associated with progression to ESRD in diabetic patients with chronic UGI symptoms.
SN  - 2093-0879
SN  - 2093-0887
ER  -