Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 17 min ago
PreprintCC BY-NCbioRxiv

A mouse model of myotonic dystrophy type 1 exhibits pain-like behavior and peripheral nociceptor hyperexcitability

  • T. S. Nelson
  • A. Calderon-Rivera
  • S. Hestehava
  • S. Loya-Lopez
  • K. Gomez
  • P. Duran
  • R. Khanna1
  1. 1University of Florida College of Medicine
Read full textPDFDOICite

Abstract

Pain is a prevalent and disabling symptom of myotonic dystrophy type 1 (DM1), yet its underlying mechanisms remain poorly understood. Using HSA LR20b transgenic mice, we found multimodal mechanical and thermal hypersensitivity. Whole-cell electrophysiological recordings demonstrated depolarized resting membrane potentials and increased action potential firing selectively in small- and medium-diameter dorsal root ganglion neurons. These findings identify peripheral nociceptor sensitization as a potential mechanism contributing to pain in DM1.

Related

  1. Direct voltage imaging of peripheral axons in vivo reveals ongoing nociceptor firing in healthy mice
    E. Sheinbach, R. Butterman, S. Lev +3
    bioRxivPreprintAll rights reservedFull textNeurosciencebioRxiv
  2. Three-Year Longitudinal Analysis of Splicing Changes in Myotonic Dystrophy Type 1
    C. Legare, L. Planco, R. Merritt +9
    bioRxivPreprintCC BYFull textBioinformatics & computational biologybioRxiv
  3. Muscle Strength and Outcome Measures for Upper Limb Function in Adults With Myotonic Dystrophy Type 1: A Cross-Sectional Study.
    Hanne Ludt Fossmo, Hilde Stendal Robinson, Karianne Grüner Bjåstad +3
    European journal of neurologyPeer-reviewedCC BY-NC-NDFull textNeuroscienceEurope PMCPMC
  4. Biallelic PIGB Variants Cause Motor Neuropathy with Conduction Blocks and Peripheral Nerve Hyperexcitability
    Gorka Fernández-Eulate, Romain Duval, Marina Konyukh +32
    Annals of NeurologyPeer-reviewedCC BY-NC-NDFull textNeuroscienceHAL
  5. LAMA2-related muscular dystrophy alters Schwann cell calcium homeostasis and increases peripheral nerve inflammation
    J. Wang, M. Khati, M. Heron +6
    bioRxivPreprintCC BYFull textNeurosciencebioRxiv

Cite

BibTeXRIS
BibTeX
@misc{nelson2026mouse,
  title = {{A mouse model of myotonic dystrophy type 1 exhibits pain-like behavior and peripheral nociceptor hyperexcitability}},
  author = {T. S. Nelson and A. Calderon-Rivera and S. Hestehava and S. Loya-Lopez and K. Gomez and P. Duran and R. Khanna},
  howpublished = {bioRxiv},
  year = {2026},
  month = sep,
  doi = {10.64898/2026.09.10.750655},
  url = {https://www.biorxiv.org/content/10.64898/2026.09.10.750655v1},
  note = {CC BY-NC},
}
RIS
TY  - UNPB
TI  - A mouse model of myotonic dystrophy type 1 exhibits pain-like behavior and peripheral nociceptor hyperexcitability
AU  - T. S. Nelson
AU  - A. Calderon-Rivera
AU  - S. Hestehava
AU  - S. Loya-Lopez
AU  - K. Gomez
AU  - P. Duran
AU  - R. Khanna
PY  - 2026
DA  - 2026/09/10
PB  - bioRxiv
DO  - 10.64898/2026.09.10.750655
UR  - https://www.biorxiv.org/content/10.64898/2026.09.10.750655v1
AB  - Pain is a prevalent and disabling symptom of myotonic dystrophy type 1 (DM1), yet its underlying mechanisms remain poorly understood. Using HSA LR20b transgenic mice, we found multimodal mechanical and thermal hypersensitivity. Whole-cell electrophysiological recordings demonstrated depolarized resting membrane potentials and increased action potential firing selectively in small- and medium-diameter dorsal root ganglion neurons. These findings identify peripheral nociceptor sensitization as a potential mechanism contributing to pain in DM1.
ER  -