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Peer-reviewedCC BY-NC-NDBMC plant biology

Integrated transcriptomic and metabolomic analyses reveal that flavonoid metabolic pathways are associated with petal discoloration in Aquilegia viridiflora s.l.

  • Tengjiao Zhang1
  • Andrey Erst2
  • Jian Zhang3
  • Mengfei Yu1
  • Elvira Tishchenko2
  • Sixin Liang1
  • Huaying Wang4
  • Hongxing Xiao5
5 affiliations
  1. 1Key Laboratory of Molecular Epigenetics of Ministry of Education, School of Life Sciences, Northeast Normal University, Changchun, 130024, China.
  2. 2Central Siberian Botanical Garden, Siberian Branch of Russian Academy of Sciences, Russia, Novosibirsk, Russia.
  3. 3School of Life Sciences, Changchun Normal University, Changji North Rd. 677, Changchun, China.
  4. 4Key Laboratory of Molecular Epigenetics of Ministry of Education, School of Life Sciences, Northeast Normal University, Changchun, 130024, China. [email protected].
  5. 5Key Laboratory of Molecular Epigenetics of Ministry of Education, School of Life Sciences, Northeast Normal University, Changchun, 130024, China. [email protected].
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Abstract

Background

The primary ornamental feature of Aquilegia plants is their coloration, which corresponds to the content of flavonoids in the petals. To investigate intrinsic mechanisms of these color changes, we performed metabolomic and transcriptomic analyses of differently colored A. viridiflora specimens.Results

A total of 385 flavonoid metabolites were identified, showing significant variations of anthocyanin and flavonoid contents among different populations. Integrated transcriptomic analysis identified key differentially expressed genes, including C4H, HCT, CHS, CHI, F3H, FLS, DFR, LAR, and ANS as strong candidate regulators of flavonoid biosynthesis. Additionally, a stepwise regression analysis with environmental variables indicated that the color variation may be influenced by the average monthly diurnal temperature range.Conclusions

This study identifies key genes and metabolites involved in regulating petal color via flavonoid biosynthesis pathways. These findings provide a foundation for further elucidating the molecular mechanisms of color variation.

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Cite

BibTeXRIS
BibTeX
@article{zhang2026integrated,
  title = {{Integrated transcriptomic and metabolomic analyses reveal that flavonoid metabolic pathways are associated with petal discoloration in Aquilegia viridiflora s.l.}},
  author = {Tengjiao Zhang and Andrey Erst and Jian Zhang and Mengfei Yu and Elvira Tishchenko and Sixin Liang and Huaying Wang and Hongxing Xiao},
  journal = {BMC plant biology},
  year = {2026},
  month = aug,
  doi = {10.1186/s12870-026-09634-z},
  url = {https://europepmc.org/article/MED/42968007},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Integrated transcriptomic and metabolomic analyses reveal that flavonoid metabolic pathways are associated with petal discoloration in Aquilegia viridiflora s.l.
AU  - Tengjiao Zhang
AU  - Andrey Erst
AU  - Jian Zhang
AU  - Mengfei Yu
AU  - Elvira Tishchenko
AU  - Sixin Liang
AU  - Huaying Wang
AU  - Hongxing Xiao
PY  - 2026
DA  - 2026/08/04
JO  - BMC plant biology
DO  - 10.1186/s12870-026-09634-z
UR  - https://europepmc.org/article/MED/42968007
AB  - Background  The primary ornamental feature of Aquilegia plants is their coloration, which corresponds to the content of flavonoids in the petals. To investigate intrinsic mechanisms of these color changes, we performed metabolomic and transcriptomic analyses of differently colored A. viridiflora specimens.Results  A total of 385 flavonoid metabolites were identified, showing significant variations of anthocyanin and flavonoid contents among different populations. Integrated transcriptomic analysis identified key differentially expressed genes, including C4H, HCT, CHS, CHI, F3H, FLS, DFR, LAR, and ANS as strong candidate regulators of flavonoid biosynthesis. Additionally, a stepwise regression analysis with environmental variables indicated that the color variation may be influenced by the average monthly diurnal temperature range.Conclusions  This study identifies key genes and metabolites involved in regulating petal color via flavonoid biosynthesis pathways. These findings provide a foundation for further elucidating the molecular mechanisms of color variation.
SN  - 1471-2229
ER  -