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Peer-reviewedCC BYHealthcare (Basel, Switzerland)

Factors Associated with Self-Reported Treatment Adherence During Pregnancy and Preliminary Psychometric Assessment of the PMAM in Primary Care.

  • Andrei Pănuș1
  • Virginia Maria Rădulescu2
  • Linda Nicoleta Bărbulescu3
  • Marian Valentin Zorilă4
  • Kamal Adina Maria5
  • Gheorghe Gindrovel Dumitra3
  • Denis Anamaria Mereț6
  • Constantin Kamal Kamal3
6 affiliations
  1. 1Department of Urology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
  2. 2Department of Medical Informatics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
  3. 3Department of Family Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
  4. 4Department of Forensic Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
  5. 5Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
  6. 6Faculty of Medicine, Transilvania University of Braşov, 500036 Braşov, Romania.
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Abstract

Background/Objectives: Medication-taking behaviour during pregnancy may be associated with treatment-related beliefs, emotional concerns, information sources, and clinician-patient communication. We examined these cross-sectional associations and the preliminary measurement properties of the Pregnancy Medication Adherence Model (PMAM). Methods: This cross-sectional study included 355 pregnant women with prescribed treatment recruited from nine general practices in Dolj County, Romania. Q25 was analysed on its five-category scale and using an operational threshold of ≥4. Internal consistency, principal component analysis, an ordinal exploratory factor analysis based on polychoric correlations, regression modelling, and review-stage sensitivity analyses addressing criterion overlap were performed. Results: Overall, 255 participants (71.8%) scored ≥4 on Q25. The four multi-item domains had Cronbach's α values of 0.897-0.935. Parallel analysis and principal-axis factoring with oblique rotation supported four factors; salient loadings were 0.797-0.925 and no secondary loading reached 0.30. In the original adjusted binary model, cognitive understanding, emotional reassurance, clinician-patient communication, and lower endorsement of information-seeking and social-influence items were associated with Q25 ≥ 4. After Q23 was removed from the communication score and Q19 and Q24 were omitted, these four associations persisted (adjusted ORs 1.90-2.55). Conclusions: The findings identify concurrent associations between medication-related perceptions and a single self-reported treatment-behaviour item. PMAM remains an exploratory framework; external psychometric evaluation and prospective assessment against defined medication-specific adherence and clinical outcomes are required before clinical use.

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Cite

BibTeXRIS
BibTeX
@article{panuș2026factors,
  title = {{Factors Associated with Self-Reported Treatment Adherence During Pregnancy and Preliminary Psychometric Assessment of the PMAM in Primary Care.}},
  author = {Andrei Pănuș and Virginia Maria Rădulescu and Linda Nicoleta Bărbulescu and Marian Valentin Zorilă and Kamal Adina Maria and Gheorghe Gindrovel Dumitra and Denis Anamaria Mereț and Constantin Kamal Kamal},
  journal = {Healthcare (Basel, Switzerland)},
  year = {2026},
  month = sep,
  doi = {10.3390/healthcare14193223},
  url = {https://europepmc.org/article/MED/42881662},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Factors Associated with Self-Reported Treatment Adherence During Pregnancy and Preliminary Psychometric Assessment of the PMAM in Primary Care.
AU  - Andrei Pănuș
AU  - Virginia Maria Rădulescu
AU  - Linda Nicoleta Bărbulescu
AU  - Marian Valentin Zorilă
AU  - Kamal Adina Maria
AU  - Gheorghe Gindrovel Dumitra
AU  - Denis Anamaria Mereț
AU  - Constantin Kamal Kamal
PY  - 2026
DA  - 2026/09/30
JO  - Healthcare (Basel, Switzerland)
DO  - 10.3390/healthcare14193223
UR  - https://europepmc.org/article/MED/42881662
AB  - Background/Objectives: Medication-taking behaviour during pregnancy may be associated with treatment-related beliefs, emotional concerns, information sources, and clinician-patient communication. We examined these cross-sectional associations and the preliminary measurement properties of the Pregnancy Medication Adherence Model (PMAM). Methods: This cross-sectional study included 355 pregnant women with prescribed treatment recruited from nine general practices in Dolj County, Romania. Q25 was analysed on its five-category scale and using an operational threshold of ≥4. Internal consistency, principal component analysis, an ordinal exploratory factor analysis based on polychoric correlations, regression modelling, and review-stage sensitivity analyses addressing criterion overlap were performed. Results: Overall, 255 participants (71.8%) scored ≥4 on Q25. The four multi-item domains had Cronbach's α values of 0.897-0.935. Parallel analysis and principal-axis factoring with oblique rotation supported four factors; salient loadings were 0.797-0.925 and no secondary loading reached 0.30. In the original adjusted binary model, cognitive understanding, emotional reassurance, clinician-patient communication, and lower endorsement of information-seeking and social-influence items were associated with Q25 ≥ 4. After Q23 was removed from the communication score and Q19 and Q24 were omitted, these four associations persisted (adjusted ORs 1.90-2.55). Conclusions: The findings identify concurrent associations between medication-related perceptions and a single self-reported treatment-behaviour item. PMAM remains an exploratory framework; external psychometric evaluation and prospective assessment against defined medication-specific adherence and clinical outcomes are required before clinical use.
SN  - 2227-9032
ER  -